Low-grade nasopharyngeal papillary adenocarcinoma: a case report and review of the literature

Wang, Xiaoli; Huang, Yan; Luo, Yao; Fan, Tingyong

doi:10.2147/ott.s100447

Cited by 12 publications

(27 citation statements)

References 23 publications

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“…Wang et al (28) used photodynamic therapy as a postoperative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma and achieved 5-year disease-free survival. In other reports, adjuvant radiotherapy was performed, and no patients developed recurrent disease or distant metastasis (4,30). These LGNPPAs were negative for TTF-1, or TTF-1 expression was not investigated.…”

Section: Discussionmentioning

confidence: 86%

Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

et al. 2020

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Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm of the nasopharynx. Accordingly, its clinical and pathological characteristics are not well-known. We report a case of TL-LGNPPA and review the relevant literature on TL-LGNPPA. A 38-year-old Japanese woman presented with a history of nasal obstruction that had persisted for 1 month after symptoms of a common cold (e.g., low-grade fever, sore throat, and fatigue). A pedunculated tumor of ∼20 mm in diameter was found on the posterior edge of the nasal septum. The tumor was endoscopically resected. Based on careful histopathological and immunohistochemical examinations, it was diagnosed as TL-LGNPPA. At 5 years after surgery, the patient remained disease-free. TL-LGNPPA has a very good prognosis, and complete resection with a sufficient safety margin is recommended as the first-line treatment. The morphological characteristics and immunohistochemical findings, especially TTF-1 positivity and thyroglobulin negativity, are important for the diagnosis.

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Section: Discussionmentioning

confidence: 86%

Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

et al. 2020

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“…12 Negativity for TG, CK20, CD15, S-100, P40, P63, CK5/6, CDX-2, prostate-specific antigen, and glial fibrillary acidic protein, and positivity for CK7, CK19, vimentin, and EMA on immunohistochemistry were reported to support the diagnosis of TL-LGNPPA in some studies. 3,5,12 Huang et al reported that S-100 was focally positive at a moderate intensity, especially in the glandular structures in three patients, but was negative in two patients. 6 In our study, immunohistochemical analysis showed that tumor cells were uniformly positive for CK7, Vim, EMA, CKpan, and TTF-1, and negative for TG, which supported the diagnoses of TL-LGNPPA.…”

Section: Discussionmentioning

confidence: 97%

“…However, a close relationship between LGNPPA and Epstein-Barr virus has not been confirmed. 5 Negative reactivity for Epstein-Barr virus encoded RNA (EBER) 3,4,6,7,9,17,18 and latent membrane protein (LMP1) 9 tumor cells was reported using in situ hybridization. KRAS, NRAS, and BRAF (V600E) gene mutations were not found in most previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Review of 28 Patients in a Single Institution

Lai

Zhai

et al. 2021

CMAR

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Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is a rare nasopharyngeal tumor. This study aimed to analyze the clinical and histopathological features of the disease, and to share our experience of its treatment. Patients and Methods: We collected demographic data, clinical symptoms, tumor location, pathological features, immunohistochemical results, treatments, and outcomes of 28 patients with pathologically confirmed LGNPPA between 2009 and 2019. Results: The median age of the 28 patients was 41.5 years, with a female: male ratio of 1.5:1 (17 females, 11 males). The most common symptom was bloodstained rhinorrhea. The neoplasms were located on the roof of the nasopharynx (RON) in 13 patients, the posterior margin of the nasal septum (PMONP) in 12 patients, the lateral wall of the nasopharynx in one case, and both the RON and PMONP in two patients. Fourteen patients were diagnosed with thyroid-like LGNPPA. Immunohistochemically, the tumors were uniformly positive for cytokeratin 7, cytokeratin 8, vimentin, epithelial membrane antigen, and pan-cytokeratin, and negative for thyroglobulin. Twenty-three patients underwent pure endoscopic surgery, three patients underwent preoperative radiotherapy, and two patients underwent radiotherapy postoperatively. All patients were alive without evidence of lymphatic or distant metastases in the follow-up period (range: 7 to 121 months). Two patients (7%, 2/28) experienced disease recurrence. Conclusion: LGNPPA is an indolent tumor with an excellent prognosis. Endonasal endoscopic excision was an effective treatment. It is important to distinguish thyroid-like LGNPPA from metastatic papillary thyroid carcinoma because these diseases have similar microscopic features but different prognoses.

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“…There was no evidence of recurrence after 4 months of surgery, and further follow-up is being carried out. [ 23 ] However, the role of adjuvant radiotherapy is not established as these well-differentiated tumors respond poorly to radiation. [ 6 ] In our case, because the surgical margin was negative, and the patient was young, he did not receive adjuvant radiation therapy or chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC

Wang

Luo

et al. 2021

Medicine

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Rationale: Nasopharyngeal papillary adenocarcinoma is a region-specific tumor originating from the nasopharyngeal surface epithelium. Owing to its rarity, more attention has been paid to its clinicopathologic features, while little effort has been made to study the gene abnormalities that drive this tumor. We describe the first case of nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC. Patient concerns: A 22-year-old female patient was diagnosed with nasopharyngeal papillary adenocarcinoma in our hospital, and she had right nasal obstruction for more than 6 months. Nasal endoscopy revealed a mass on the posterior roof of the nasopharynx. Diagnoses: Immunohistochemical staining showed that the tumor cells were diffusely positive for transcription termination factor 1, vimentin, CK19, glypican-3, and CK7, and negative for melanocyte, CK5/6, CK20, P53, P63, S100, smooth muscle actin, p16, PAX8, and thyroglobulin. The Ki-67 index was approximately 5%; EBV-encoded small nuclear RNA was negative. Interventions: The tumor was completely excised on endoscopy with a negative surgical margin. Outcomes: No sign of recurrence was observed during the 3-year follow-up period. Lessons: Owing to its rarity, pathologists should be aware of this unusual neoplasm to avoid misdiagnosis. Further studies are needed to further characterize the relationship between ROS1-GOPC fusion and the pathogenesis of this carcinoma and its response to tyrosine kinase inhibitors in relapsed cases.

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Low-grade nasopharyngeal papillary adenocarcinoma: a case report and review of the literature

Cited by 12 publications

References 23 publications

Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Review of 28 Patients in a Single Institution

Nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC

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