Different Routes of Administration Lead to Different Oxidative Damage and Tissue Disorganization Levels on the Subacute Cadmium Toxicity in the Liver

Mouro, Viviane Gorete Silveira; Ladeira, Luiz Carlos Maia; Lozi, Amanda Alves; Medeiros, Thiago Soares de; Silva, Mariany Ribeiro; Oliveira, Elizabeth Lopes de; Melo, Fabiana Cristina Silveira Alves de; Matta, Sérgio Luís Pinto da

doi:10.1007/s12011-020-02570-5

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…Cd exposure was also found to increase the activity of GST in conformity with the report of Mouro et al [49] confirming the participation of GST in the inactivation of Cd [50]. From this present study, the separate treatment with the phenolics recovered GST activity, but the combination of the phenolics (RUT+GAL+QUE) showed a greater potency.…”

Section: Andrologiasupporting

confidence: 92%

Combined Protective Effects of Quercetin, Rutin, and Gallic Acid against Cadmium-Induced Testicular Damages in Young-Adult Rats

et al. 2023

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Cadmium (Cd) is a toxic metal that damages several tissues of animals and humans including the testis. The ameliorative effects of quercetin (QUE), rutin (RUT), and gallic acid (GAL) at 20 mg kg-1 body weight alone or in combination against testicular injury induced by Cd (24 mg kg-1 body weight) in male Wistar rats were evaluated in this study. Forty-two (42) rats were randomly grouped into six (6) groups: (1) vehicle control group, (2) Cd group, (3) RUT+Cd group, (4) GAL+Cd group, (5) QUE+Cd group, and (6) RUT+GAL+QUE+Cd group. At the end of the oral gavage of the tested chemicals, the rats were sacrificed, blood samples were collected, and testes were harvested and processed for biochemical assays. Cd exposure damaged the testis (smaller epithelium thickness and spermatogenesis index and sloughing of the epithelium); increased lipid peroxidation, glutathione S-transferase activity, and DNA fragmentation; and diminished glutathione reductase activity and serum testosterone level 40 days posttreatment. Treatment with the phenolics separately or in combination attenuated the effect of Cd on serum testosterone, glutathione reductase and glutathione S-transferase activities, lipid peroxidation, and percent fragmented DNA. The increased nitric oxide concentration in the QUE+Cd group was attenuated to control values in the combined (RUT+GAL+QUE+Cd) exposure group. Coadministration of the phenolics appears to have more substantial protective effects than their single effects against Cd-induced testicular DNA damage, glutathione S-transferase activity, and the recovery of testosterone levels and spermatogenesis index. Overall, the tested phenolics can reduce testicular damage more efficiently in their combined form than individual administration.

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Section: Andrologiasupporting

confidence: 92%

Combined Protective Effects of Quercetin, Rutin, and Gallic Acid against Cadmium-Induced Testicular Damages in Young-Adult Rats

et al. 2023

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“…Cd 2+ is a common pollutant in the environment, more studies are needed to study the comprehensive toxic effects of Cd 2+ . Cd 2+ has toxic effects on the liver, kidney, brain, skin as well as other organs, and oxidative stress is crucial to its toxic effects ( 1 , 21 – 23 ).…”

Section: Discussionmentioning

confidence: 99%

Study on the mechanism of cadmium chloride pollution accelerating skin tissue metabolism disorder, aging and inhibiting hair regeneration

Du¹,

Dong²,

Wang³

et al. 2022

Front. Public Health

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Drinking water contaminated by Cd2+ is one of the main pathways for Cd to enter the body. The skin barrier is destroyed when the skin is contaminated by environmental Cd2+, however, the detailed mechanism by which Cd2+ induces skin metabolic disorder, and senescence and affects hair regeneration is not completely understood. In this study, 18 C57BL/6 mice were randomly divided into a Control group, a Low-dose group, and a High-dose group with 6 mice in each group, and intragastrically administered with different concentrations of cadmium chloride once a day, respectively. After 1 month of intervention, the skin tissues on the back of mice were collected for non-targeted metabolomics analysis, and the related proteins were detected by immunofluorescence assay. Non-targeted metabolomics analysis result showed that compared with the Control group, there were 29 different metabolites, mainly including lysophospholipids, fatty acids, and bile acids, in the Low-dose group, and 39 differential metabolites in the High-dose group, in addition to the above compounds, there were more amino acid compounds, and most of the metabolites had a reduced response after administration. Immunofluorescence assay result showed that the higher the concentration of cadmium chloride led to the more obvious the proliferation inhibition and apoptosis promotion effects of skin cells, and the more significant damage to hair follicle stem cells. Thus, our findings demonstrate that cadmium chloride pollution can accelerate skin metabolism disorder, and aging and impair hair regeneration.

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Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling

et al. 2022

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Different Routes of Administration Lead to Different Oxidative Damage and Tissue Disorganization Levels on the Subacute Cadmium Toxicity in the Liver

Cited by 4 publications

References 54 publications

Combined Protective Effects of Quercetin, Rutin, and Gallic Acid against Cadmium-Induced Testicular Damages in Young-Adult Rats

Combined Protective Effects of Quercetin, Rutin, and Gallic Acid against Cadmium-Induced Testicular Damages in Young-Adult Rats

Study on the mechanism of cadmium chloride pollution accelerating skin tissue metabolism disorder, aging and inhibiting hair regeneration

Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling

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