Different risk factors influence peptic ulcer disease development in a Brazilian population

Suzuki, Rodrigo Buzinaro; Cola, Rodrigo Faria; Cola, Larissa Tranquilino Bardela; Ferrari, Camila Garcia; Ellinger, Fred; Therezo, Altino Luiz Silva; Silva, Luís Carlos da; Eterovic, André; Sperança, Márcia Aparecida

doi:10.3748/wjg.v18.i38.5404

Cited by 16 publications

(12 citation statements)

References 52 publications

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“…Corroborating the results of the cited study, 28 no progressive neoplasia was found on the present UDE analysis.…”

Section: ■ Discussionsupporting

confidence: 90%

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Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Amorim¹,

Furuya²,

Marques³

et al. 2017

Medical Express

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OBJECTIVE:To endoscopically assess the upper digestive tract of adult patients with newly diagnosed dermatomyositis; to correlate possible changes in the gastrointestinal tract with demographic, clinical and laboratory features in this population. METHOD: A cross-sectional study evaluating 65 newly diagnosed dermatomyositis cases from 2004 to 2015 was carried out. We excluded patients with clinically amyopathic dermatomyositis, overlap dermatomyositis, polymyositis, liver diseases, prior gastric surgery, upper gastrointestinal tract symptoms (except for upper dysphagia), systemic infections, alcohol consumption and smoking. RESULTS: Mean age of patients was 44.9 years, with disease duration of four months. Endoscopic findings were observed in 70.8% of patients. (1) Esophageal disease/gastric distress was documented in 18.5% of patients: erosive distal esophagitis (16.9%) and non-erosive distal esophagitis distal (1.5%); (2) gastric distress in 63.1% of cases: antral gastritis (42.3%) and pangastritis (27.8%); (3) duodenal involvement in 15.4% of patients: bulbar duodenitis (10.9%) and duodenal ulcers (7.7%). There were no neoplasic lesions. On multivariate analysis, erosive distal esophagitis was less associated with older patients. Males had a higher prevalence of erosive gastritis. Enanthematous pangastritis was less associated with lesions with "V-neck" sign lesions. CONCLUSIONS: This study provides the first estimates of the prevalence of high endoscopic findings in adult patients with newly diagnosed dermatomyositis. The results may be relevant to guide conduct in digestive disorders with upper digestive endoscopy, and point to the need for pharmacological prevention of digestive tract lesions in these patients. Further studies are needed to validate this data and evaluate patients with dyspeptic symptoms.

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“…Corroborating the results of the cited study, 28 no progressive neoplasia was found on the present UDE analysis.…”

Section: ■ Discussionsupporting

confidence: 90%

“…Although the study was conducted at a reference center, Suzuki et al 28 found a 6% prevalence of duodenal ulcer in patients with dyspeptic symptoms. This result may suggest an increased prevalence of duodenal ulcer in our patients, since the present study only included asymptomatic dyspeptic cases.…”

Section: ■ Discussionmentioning

confidence: 98%

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Amorim¹,

Furuya²,

Marques³

et al. 2017

Medical Express

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“…Out of 146 males in the study, 4 were diagnosed with a malignant ulcer, whereas out of 51 female patients, malignancy was detected in 2 of them, male-to-female ratio in the studied patients was 2.86:1, which complies with the fact that peptic ulcer disease is more common in male sex compared to females also described by Rodrigo et al 7 The incidence of malignant ulcer in alcoholics was 3.37% compared to 0.92% in nonalcoholics.…”

Section: Discussionsupporting

confidence: 85%

Endoscopic Study of Gastric Ulcer With Reference to Malignancy

Mohanty¹,

Mishra²,

Mohapatra³

et al. 2017

jebmh

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“…H. pylori infection was demonstrated as an independent risk factor for histological gastritis,6 inflammation, and peptic ulcer 5,34,35…”

Section: Discussionmentioning

confidence: 99%

A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

Mattar¹,

Marques²,

Santos³

et al. 2013

CEG

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ObjectiveTo verify whether the variable number of tandem repeat (VNTR) polymorphism in the IL-1RN gene that encodes the interleukin (IL)-1 receptor antagonist (IL-1Ra) plays a role in the outcome of gastrointestinal diseases associated with Helicobacter pylori (H. pylori) infection.MethodsPatients with normal endoscopy (n = 71), inflammation of the upper gastrointestinal tract only (n = 196), gastric ulcer (n = 28), duodenal ulcer (n = 76), and gastric cancer (n = 19) were studied. H. pylori infection was diagnosed by the urease test, histological examination, and polymerase chain reaction. The IL-1 receptor antagonist gene (IL-1RN intron 2 VNTR) was analyzed by polymerase chain reaction. Gastritis was scored according to the updated Sydney system of classification.ResultsH. pylori infection was an independent risk factor for mild (odds ratio [OR] = 5.53 [95% confidence interval [CI] = 2.63–11.64; P < 0.05]), moderate (OR = 83.93 [95% CI = 29.7–237.18; P < 0.05]) and marked (OR = 47.47 [95% CI = 5.39–418.05; P < 0.05]) gastritis. The carriage of IL-1RN*2/*2 had a significant protective effect of H. pylori infection (OR = 0.31 [95% CI = 0.17–0.57; P < 0.05]). H. pylori infection was identified as an independent risk of inflammation, duodenal ulcer, and gastric ulcer. The carriage of IL-1RN*2/*2 was an independent risk factor for gastric cancer (OR = 5.81 [95% CI = 1.06–31.98; P < 0.05]); nonetheless, the carriage of allele 2 (IL-1RN*2/*2 plus IL-1RN*L/*2) had an independent protective effect on duodenal ulcer (OR = 0.45 [95% CI = 0.22–0.91; P < 0.05]).ConclusionsAllele 2 of the VNTR IL-1RN polymorphism had a protective effect against duodenal ulcer and H. pylori infection; however, it increased the risk of gastric cancer.

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Different risk factors influence peptic ulcer disease development in a Brazilian population

Abstract: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metaplasia; and H. pylori of vacA m1 genotype for DU.

Cited by 16 publications

References 52 publications

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Endoscopic Study of Gastric Ulcer With Reference to Malignancy

A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

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