Different relations between schedule-induced polydipsia and impulsive behaviour in the Spontaneously Hypertensive Rat and in high impulsive Wistar rats: Questioning the role of impulsivity in adjunctive behaviour

Íbias, Javier; Pellón, Ricardo

doi:10.1016/j.bbr.2014.06.010

Cited by 20 publications

(22 citation statements)

References 51 publications

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“…In contrast, SHRs maintained their adjunctive drinking despite a reduction in feeding rate. These results are consistent with previous reports (Íbias & Pellón, 2011, 2014). …”

Section: Discussionsupporting

confidence: 94%

“…This learning deficit relates to other deficits observed in WKY rats under a variety of different behavioural tasks (e.g., McAuley et al, 2009). Conversely, SHRs developed SIP quicker than Wistar controls, and this could reflect less competition for expression from other behaviours within inter-food intervals (Íbias & Pellón, 2011) and/or an increased hyperactivity (Íbias & Pellón, 2014). Overall the present results seem to reflect that the functionality of SIP is more in line with adjustments of behaviour to reinforcement intermittency (see Falk, 1971; Killeen & Pellón, 2013) rather than with an anxiety-reduction function.…”

Section: Discussionmentioning

confidence: 99%

“…Comparisons of SIP between SHR, Wistar and Wistar Kyoto (WKY) rats have shown that (a) there are no significant difference in SIP among strains when the inter-food interval is short (30 s), but (b) whereas SIP declines with longer inter-food intervals (approximately 60 s) in WKY and Wistar rats, SIP in SHR remains relatively high (Íbias & Pellón, 2011, 2014). Reduced SIP in control strains may occur because of (a) a reduction in the proportion of inter-food intervals that contain drinking episodes, (b) an increase in the latency to initiate drinking episodes, (c) a reduction in the duration of drinking episodes, and/or (d) a reduction in the rate of licking during a drinking episode.…”

Section: Introductionmentioning

confidence: 99%

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A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD

Íbias

Pellón

Sanabria

2015

Behavioural Brain Research

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Recent research has suggested that frequent short bursts of activity characterize hyperactivity associated with attention deficit hyperactivity disorder (ADHD). This study determined whether such pattern is also visible in schedule-induced polydipsia (SIP) in the spontaneously hypertensive rat (SHR), an animal model of ADHD. Male SHR, Wistar Kyoto (WKY) and Wistar rats were exposed to 40 sessions of SIP using a multiple fixed-time (FT) schedule of food delivery with FT 30-s and FT 90-s components. Stable performance was analysed to determine the extent to which SIP-associated drinking is organized in bouts. The Bi-Exponential Refractory Model (BERM) of free-operant performance was applied to schedule-induced licks. A model comparison analysis supported BERM as a description of SIP episodes: licks were not produced at a constant rate but organized into bouts within drinking episodes. FT 30-s induced similar overall licking rates, latencies to first licks and episode durations across strains; FT 90-s induced longer episode durations in SHRs and reduced licking rate in WKY and Wistar rats to nearly baseline levels. Across schedules, SHRs made more and shorter bouts when compared to the other strains. These results suggest an incentive-induced hyperactivity in SHR that has been observed in operant behavior and in children with ADHD.

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“…In contrast, SHRs maintained their adjunctive drinking despite a reduction in feeding rate. These results are consistent with previous reports (Íbias & Pellón, 2011, 2014). …”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD

Íbias

Pellón

Sanabria

2015

Behavioural Brain Research

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“…On the other hand, the RHA and RLA strains are well-characterized phenotypes that show rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box test with different emotional and motivational profiles (for reviews see 19,[48][49][50][51] 11 a common feature of the lack of executive control over actions is present in both impulsivity and compulsivity. 56 Thus, we can deduce that the frequency of licking in SIP predicts deficits in inhibitory control, and when accompanied by a high intensity of licking, reveals compulsivity and possible tendencies for engaging in excessive habitual behavior.…”

Section: Experiments 1: Strain-dependent Sip and Phenotype Differencmentioning

confidence: 99%

“…17 In addition, the selective breeding of Roman high-avoidance (RHA) and Roman low-avoidance (RLA) rats for rapid vs poor acquisition of active avoidance behavior in the shuttle box test resulted in 2 phenotypes that present with differences in SIP acquisition. Other strains, such as the spontaneously hypertensive rats (SHR) that are characterized as hyperactive and impulsive in terms of their exacerbated sensitivity to delayed reinforcement, display increased SIP drinking when compared with Wistar-Kyoto (WKY) control rats, 11,21 as well as 2 rat lines selectively bred for high-ethanol preference compared with their control counterparts. Other strains, such as the spontaneously hypertensive rats (SHR) that are characterized as hyperactive and impulsive in terms of their exacerbated sensitivity to delayed reinforcement, display increased SIP drinking when compared with Wistar-Kyoto (WKY) control rats, 11,21 as well as 2 rat lines selectively bred for high-ethanol preference compared with their control counterparts.…”

mentioning

confidence: 99%

Excessive habit formation in schedule‐induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Merchán

Mora

Gago

et al. 2018

Genes Brain and Behavior

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Schedule-induced polydipsia (SIP) is an animal model of compulsive drinking that selects for individual differences and varies across rat strains. The aim of this study was to investigate excessive habit formation by analyzing the SIP licking microstructure among rat strains, and to compare the brain areas activated by SIP in different populations. Wistar, Long Evans and Roman High- and Low-Avoidance rat strains were compared using a cluster analysis of 2 main variables, that is, frequency of licking (percentage of interpellet intervals with drinking episodes) and intensity of licking (mean number of licks per interpellet interval), and were found to exhibit high intensity and frequent licking (compulsive drinkers, CD), low intensity but frequent licking (habitual drinkers, HD), and low intensity and low-frequency licking (low drinkers, LD). The Wistar strain showed a higher frequency and intensity of licking, and had the largest group of CD rats when compared with the other strains. Regarding the acquisition of SIP, CD rats showed a higher intensity of licking when compared with the HD and LD rats. Moreover, c-Fos quantification revealed that rats in the CD group showed hyperactivity in the lateral orbitofrontal cortex and basolateral amygdala when compared with the LD group. Analyzing the SIP microstructure could be a valuable tool for understanding the role of excessive habit formation in the development of compulsive drinking and its underpinning neurobiological mechanisms.

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Timing and delay discounting in attention‐deficit/hyperactivity disorder: A translational approach

Fox,

Nicholson,

Singha

et al. 2023

Developmental Psychobiology

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Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that often presents with abnormal time perception and increased impulsive choice behavior. The spontaneously hypertensive rat (SHR) is the most widely used preclinical model of the ADHD-Combined and ADHD-Hyperactive/Impulsive subtypes of the disorder. However, when testing the spontaneously hypertensive rat from Charles River (SHR/NCrl) on timing and impulsive choice tasks, the appropriate control strain is not clear, and it is possible that one of the possible control strains, the Wistar Kyoto from Charles River (WKY/NCrl), is an appropriate model for ADHD-Predominately Inattentive. Our goals were to test the SHR/NCrl, WKY/NCrl, and Wistar (WI; the progenitor strain for the SHR/NCrl and WKY/NCrl) strains on time perception and impulsive choice tasks to assess the validity of SHR/NCrl and WKY/NCrl as models of ADHD, and the validity of the WI strain as a control. We also sought to assess impulsive choice behavior in humans diagnosed with the three subtypes of ADHD and compare them with our findings from the preclinical models. We found SHR/NCrl rats timed faster and were more impulsive than WKY/NCrl and WI rats, and human participants diagnosed with ADHD were more impulsive compared to controls, but there were no differences between the three ADHD subtypes.

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Different relations between schedule-induced polydipsia and impulsive behaviour in the Spontaneously Hypertensive Rat and in high impulsive Wistar rats: Questioning the role of impulsivity in adjunctive behaviour

Cited by 20 publications

References 51 publications

A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD

A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD

Excessive habit formation in schedule‐induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Timing and delay discounting in attention‐deficit/hyperactivity disorder: A translational approach

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