Different regulation of branched-chain amino acid on food intake by TOR signaling in Chinese perch (Siniperca chuatsi)

Chen, Ke; Zhang, Zhen; Li, Jiao; Xie, Shuang; Shi, Linlin; He, Yuhui; Liang, Xu‐Fang; Zhu, Qiang-Sheng; He, Shan

doi:10.1016/j.aquaculture.2020.735792

Cited by 26 publications

(23 citation statements)

References 44 publications

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“…Mandarin fish have a food preference for live bait and show certain eating disorders with dead bait fish or pellet feed. The increased mortality rate of mandarin fish under pellet feeding conditions seriously affects its economic benefits [10,66]. The eating disorder is characterized by abnormal feeding behaviors associated with the establishment of Intestinal villi height (A) and basement membrane thickness (B) of mandarin fish in dif ferent feeding groups (LBFD, PFD, PFDCB, PFDLR and PFDLP) after being fed for 28 days.…”

Section: Discussionmentioning

confidence: 99%

“…Food preference is an innate behavioral trait which is affected by both genes and the environment [8,9]. The hypothalamus contains orexigenic neurons that express neuropeptide Y (NPY) and agouti-related peptide (AgRP), which participate in food intake control and are regulated by the peripheral hormone leptin and ghrelin [10,11]. NPY is a peptide composed of 36 amino acids.…”

Section: Introductionmentioning

confidence: 99%

“…Mandarin fish (Siniperca chuatsi) is a precious freshwater farmed fish with unique live bait feeding habits, and it does not easily accept dead bait or pellet feed [10,66]. The preference for a live bait diet increases the cost of mandarin fish farming and the risk of infectious diseases, limiting the development of mandarin fish farming.…”

Section: Introductionmentioning

confidence: 99%

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Probiotics Improve Eating Disorders in Mandarin Fish (Siniperca chuatsi) Induced by a Pellet Feed Diet via Stimulating Immunity and Regulating Gut Microbiota

Chen

Liu

et al. 2021

Microorganisms

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Eating disorders are directly or indirectly influenced by gut microbiota and innate immunity. Probiotics have been shown to regulate gut microbiota and stimulate immunity in a variety of species. In this study, three kinds of probiotics, namely, Lactobacillus plantarum, Lactobacillus rhamnosus and Clostridium butyricum, were selected for the experiment. The results showed that the addition of three probiotics at a concentration of 108 colony forming unit/mL to the culture water significantly increased the ratio of the pellet feed recipients and survival rate of mandarin fish (Siniperca chuatsi) under pellet-feed feeding. In addition, the three kinds of probiotics reversed the decrease in serum lysozyme and immunoglobulin M content, the decrease in the activity of antioxidant enzymes glutathione and catalase and the decrease in the expression of the appetite-stimulating regulator agouti gene-related protein of mandarin fish caused by pellet-feed feeding. In terms of intestinal health, the three probiotics reduced the abundance of pathogenic bacteria Aeromonas in the gut microbiota and increased the height of intestinal villi and the thickness of foregut basement membrane of mandarin fish under pellet-feed feeding. In general, the addition of the three probiotics can significantly improve eating disorders of mandarin fish caused by pellet feeding.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Probiotics Improve Eating Disorders in Mandarin Fish (Siniperca chuatsi) Induced by a Pellet Feed Diet via Stimulating Immunity and Regulating Gut Microbiota

Chen

Liu

et al. 2021

Microorganisms

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“…Leucine is the unique branched-chain amino acid (BCAA) whose levels are detected by mammalian hypothalamic amino acid sensing mechanisms (Efeyan et al, 2015;Heeley and Blouet, 2016). In fish, available evidence is restricted to rainbow trout (Comesaña et al, 2018a,b) and Chinese perch (Chen et al, 2021), suggesting the existence of mechanisms based on BCAA metabolism, glutamine metabolism, mechanistic target of rapamycin (mTOR), general control nonderepressible 2 kinase, and taste receptor signaling.…”

Section: Introductionmentioning

confidence: 99%

Integration of Nutrient Sensing in Fish Hypothalamus

Soengas

2021

Front. Neurosci.

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The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid, and amino acid) systems would result in AMP-activated protein kinase (AMPK) inhibition and activation of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR). Changes in these signaling pathways would control phosphorylation of transcription factors cAMP response-element binding protein (CREB), forkhead box01 (FoxO1), and brain homeobox transcription factor (BSX) leading to food intake inhibition through changes in the expression of neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opio melanocortin (POMC), and cocaine and amphetamine-related transcript (CART). The present mini-review summarizes information on the topic and identifies gaps for future research.

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“…Mechanistic target of rapamycin (mTOR), or TOR in Drosophila, is a key regulator of metabolism. mTOR is composed of two distinct kinase complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), which are characterized by the signature components Raptor and Rictor, respectively 74,[80][81][82] . Branched chain amino acids (BCAA), including leucine, isoleucine, and valine, play a crucial role in the activation of the TOR pathway 83 .…”

Section: Metabolomic Characterizationmentioning

confidence: 99%

Combining metabolomics and experimental evolution reveals key mechanisms underlying longevity differences in laboratory evolved Drosophila melanogaster populations

Phillips

Arnold

Vue

et al. 2021

Preprint

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Experimental evolution with Drosophila melanogaster has been used extensively for decades to study aging and longevity. In recent years, the addition of DNA and RNA sequencing to this framework has allowed researchers to leverage the statistical power inherent to experimental evolution study the genetic basis of longevity itself. Here we incorporated metabolomic data into to this framework to generate even deeper insights into the physiological and genetic mechanisms underlying longevity differences in three groups of experimentally evolved D. melanogaster populations with different aging and longevity patterns. Our metabolomic analysis found that aging alters mitochondrial metabolism through increased consumption of NAD+ and increased usage of the TCA cycle. Combining our genomic and metabolomic data produced a list of biologically relevant candidate genes. Among these candidates, we found significant enrichment for genes and pathways associated with neurological development and function, and carbohydrate metabolism. While we do not explicitly find enrichment for aging canonical genes, neurological dysregulation and carbohydrate metabolism are both known to be associated with accelerated aging and reduced longevity. Taken together, our results in total provide very plausible genetic mechanisms for what might be driving longevity differences in this experimental system. More broadly, our findings demonstrate the value of combining multiple types of omic data with experimental evolution when attempting to dissect mechanisms underlying complex and highly polygenic traits like aging.

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Different regulation of branched-chain amino acid on food intake by TOR signaling in Chinese perch (Siniperca chuatsi)

Cited by 26 publications

References 44 publications

Probiotics Improve Eating Disorders in Mandarin Fish (Siniperca chuatsi) Induced by a Pellet Feed Diet via Stimulating Immunity and Regulating Gut Microbiota

Probiotics Improve Eating Disorders in Mandarin Fish (Siniperca chuatsi) Induced by a Pellet Feed Diet via Stimulating Immunity and Regulating Gut Microbiota

Integration of Nutrient Sensing in Fish Hypothalamus

Combining metabolomics and experimental evolution reveals key mechanisms underlying longevity differences in laboratory evolved Drosophila melanogaster populations

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