Different phenotypes of polycystic ovary syndrome by Rotterdam criteria are differently steroidogenic but similarly insulin resistant

Dysregulation of glucose metabolism even in Chinese PCOS women with normal glucose tolerance

“…Preserved β cell function of lean PCOS women in this study went against the results of most North American studies [4,8,9]. The dispute may partly result from ethnicity and history of type 2 diabetes.…”

“…It is important to prevent glucose metabolic disorder of PCOS as early as possible since more than 40% of PCOS women might develop impaired glucose tolerance or type 2 diabetes [2,3]. However, the early interventions of improving glucose metabolism were seldom adopted because the glucose levels of PCOS women were normal before developing impaired glucose tolerance.Insulin resistance is a common feature of PCOS [4][5][6], and when insulin secretion from β cell becomes inadequate in relation to insulin resistance, impaired glucose tolerance and type 2 diabetes will eventually develop [7,8]. However, few studies investigated glucose levels distribution of PCOS before developing impaired glu- In conclusion, insulin resistance and dysregulation of glucose metabolism were common in Chinese PCOS women with normal glucose tolerance.…”

“…Insulin resistance is a common feature of PCOS [4][5][6], and when insulin secretion from β cell becomes inadequate in relation to insulin resistance, impaired glucose tolerance and type 2 diabetes will eventually develop [7,8]. However, few studies investigated glucose levels distribution of PCOS before developing impaired glu- In conclusion, insulin resistance and dysregulation of glucose metabolism were common in Chinese PCOS women with normal glucose tolerance.…”

“…Especially for PCOS women with normal glucose tolerance, lots of studies (in particular from North American) found impaired β cell function [4,8,9], while other studies reported preserved β cell function [7,10,11]. The difference of β cell function in previous studies might be related to failing to take into account the effect of confounding variables, such as ethnicity [12], medication history [13], a family history of type 2 diabetes [14].…”

Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active

“…In women, PCOS is the major cause of infertility and other consequences ranging from hirsutism and acne first appearing during adolescence to long-term health risks, in particular a significant increase in the risk of developing type II diabetes in later life (Gorry et al, 2006, Wang et al, 2010. Although the clinical and biochemical features of PCOS are well described, our paper provides novel and unique insight into the regulation of LHCGR receptor in granulosa cells of normal and PCOS women.…”