Different pH-Values of Release Medium Influence the Drug Release from PTX-PCL Microspheres

Abstract

In this paper we study in vitro release of paclitaxel-loade polycaprolactone sustained-release microspheres. Different pH values release medium is used to simulate pH conditions in different parts of body, and determination the paclitaxel in Microspheres by High Performance Liquid Chromatography according Chinese Pharmacopoeia 2010. The experimental results indicate that the microspheres release rates of same drug loading content in buffer solution of pH 7.35 is the fastest, and in the pH 1.2 is the slowest. The drug release behavior according to the first-order model and it is not affected by drug loading rate of microspheres. The prepared paclitaxel-loade polycaprolactone sustained-release microspheres has good sustained release effect in different release media, and the results can provide references for further study of in vivo release.

Copolymer Involving 2-Hydroxyethyl Methacrylate and 2-Chloroquinyl Methacrylate: Synthesis, Characterization and In Vitro 2-Hydroxychloroquine Delivery Application

“…The nature of the environment in which drugs are released greatly influences the dynamics of drug release in a target organ. Indeed, various studies have been carried out on the influence of the medium such as the pH [ 53 , 54 ], the enzymes [ 54 , 55 ] and the bacteria [ 56 , 57 ] on the dynamics of the drug released by the drug delivery systems and the results obtained were very striking. In this work, the effect of pH media on the dynamics of HCQ released from CQMA- co -HEMA drug carrier systems was performed at pH media 1, 3, 5 and 7, and the results obtained for 24 and 72 h are plotted for comparison in Figure 19 .…”

SYL3C aptamer-anchored microemulsion co-loading β-elemene and PTX enhances the treatment of colorectal cancer

“…The PTX release profile of microemulsions was measured by a modified dialysis method (Ruan et al., 2012). 5 mL of EP-MEs and SYL3C/EP-MEs packed in the dialysis bag (molecular weight cutoff, MWCO, 5 kDa) were placed in a dissolution apparatus (VFS-IR, Henan, China), followed by immersion in 250 mL of phosphate buffer saline (PBS) with various pH values (5.0, 6.5 and 7.4) at 37 °C under a stirring at 90 rpm, respectively.…”