Different lansoprazole (LA) dosages in H. pylori (Hp) eradication therapy: A prospective multicenter randomized study comparing 30 MG B.I.D. vs. 15 MG B.I.D.

Mario, F. Di; Buda, Andrew J.; Bò, N. Dal; Bastiani, Rudi De; Grassi, S A; Crestani, Bruno; Battaglia, Giuseppe; Franceschi, Marilisa; Bona, Manuela De; Salandin, S

doi:10.1016/s0016-5085(98)80421-6

Cited by 6 publications

(13 citation statements)

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“…Eighteen studies were initially evaluated for meta‐analyses 12–14 , . 17–31 Two were subdivided into two parts because they analysed four branches of treatment with different durations of eradication therapy. 13 , 20 …”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies were initially evaluated for metaanalyses. [12][13][14][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Two were subdivided into two parts because they analysed four branches of treatment with different durations of eradication therapy. 13,20 All studies compared single vs. double doses of proton pump inhibitor (omeprazole, lansoprazole, pantoprazole or rabeprazole) associated with a twice-daily combination of antibiotics.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies were included in the meta-analysis. [12][13][14][17][18][19][20][21][22][23][24] The characteristics of the studies are shown in Table 2.…”

Section: Studies Includedmentioning

confidence: 99%

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Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta‐analysis

Vallve

Vergara

Gisbert

et al. 2002

Aliment Pharmacol Ther

121

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Background: Triple therapies combining a double dose of proton pump inhibitor plus two antibiotics are the standard treatment for Helicobacter pylori infection. Some reports suggest that the use of half the dose of proton pump inhibitor is equally effective. Aim: To compare the efficacy of a single vs. double dose of proton pump inhibitor in triple therapy. Methods: We conducted a MEDLINE search. The search strategy included the words (pylori) AND (triple, PPI, proton pump, omeprazole, rabeprazole, pantoprazole, lansoprazole, clarithromycin, amoxicillin, amoxycillin or metronidazole). Abstracts of the articles obtained and papers presented at the European Helicobacter pylori Study Group and American Gastroenterological Association congresses from 1996 to 2001 were examined. Inclusion criteria were: (i) randomized studies with at least two branches of triple therapy including a proton pump inhibitor and two standard antibiotics; (ii) branches could differ only in terms of proton pump inhibitor dosage. A meta‐analysis was conducted using conventional shareware (Review Manager 4.1). Results: Thirteen studies met the inclusion criteria with a total of 2391 patients. Cure rates with double doses of proton pump inhibitor were higher in both the intention‐to‐treat analysis (83.9% vs. 77.7%; Peto odds ratio, 1.51; 95% confidence interval, 1.23–1.85; P < 0.01) and per protocol analysis (89% vs. 81%; Peto odds ratio, 1.96; 95% confidence interval, 1.55–2.47; P < 0.01). Conclusion: Triple therapies containing a single dose of proton pump inhibitor are less effective than those containing a standard double dose of proton pump inhibitor.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta‐analysis

Vallve

Vergara

Gisbert

et al. 2002

Aliment Pharmacol Ther

121

View full text Add to dashboard Cite

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“…This is in contrast to other studies showing better efficacy with the double dosage regimen 31 , . 32 Lamouliatte found a significant difference between 30 mg and 60 mg lansoprazole only after 10 days of therapy, but not after 7 days 33 . In a meta‐analysis of six French studies including 577 patients, the results were significantly better with a double dosage of proton pump inhibitors, 34 although the overall eradication rate in France is 10% below the rates known from the literature.…”

Section: Discussionmentioning

confidence: 97%

Short‐term triple therapy with lansoprazole 30 mg or 60 mg, amoxycillin and clarithromycin to eradicate Helicobacter pylori

Sieg

Sellinger

Schlauch

et al. 1999

Aliment Pharmacol Ther

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“…Success was achieved in 91% of patients allocated the higher dose of PPI compared with 84% in the other group ( P =0·01). An Italian study (Di Mario et al. 1997) confirmed these findings, suggesting standard doses of PPIs need to be prescribed twice daily for maximum PAC efficacy.…”

Section: The Optimum Treatment For H Pylorimentioning

confidence: 71%

Helicobacter pylori: a clinical update

Martin

Murphy

2001

J Appl Microbiol

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Different lansoprazole (LA) dosages in H. pylori (Hp) eradication therapy: A prospective multicenter randomized study comparing 30 MG B.I.D. vs. 15 MG B.I.D.

Cited by 6 publications

References 0 publications

Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta‐analysis

Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta‐analysis

Short‐term triple therapy with lansoprazole 30 mg or 60 mg, amoxycillin and clarithromycin to eradicate Helicobacter pylori

Helicobacter pylori: a clinical update

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