Short‐term triple therapy with lansoprazole 30 mg or 60 mg, amoxycillin and clarithromycin to eradicate <i>Helicobacter pylori</i>

Sieg,; Sellinger,; Schlauch,; HÖrner,; Fuchs, Alexandra

doi:10.1046/j.1365-2036.1999.00540.x

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…This difference was not observed in triple therapy groups. This was in accordance with the results obtained by Moayyedi et al 83 and Sieg et al 84 and perhaps the dosage of PPI was not a major factor in H. pylori eradication when combined with two potent antimicrobials such as clarithromycin, amoxycillin or metronidazole. Proton pump inhibitor administration for 4 weeks or more did not affect the H. pylori eradication rate.…”

Section: Discussionsupporting

confidence: 93%

Pooled analysis of Helicobacter pylori eradication regimes in Asia

Wang

Wong

Lam

2000

J of Gastro and Hepatol

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Proton pump inhibitor-based triple therapy with either clarithromycin, amoxycillin or metronidazole was one of the most commonly used and effective anti-H. pylori triple therapy regimens in Asia. The classical triple therapy with a bismuth, tetracycline and metronidazole combination has a similar efficacy. The results of anti-H. pylori treatment in Asia are not different from those in Western countries.

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Section: Discussionsupporting

confidence: 93%

Pooled analysis of Helicobacter pylori eradication regimes in Asia

Wang

Wong

Lam

2000

J of Gastro and Hepatol

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“…Eighteen studies were initially evaluated for meta‐analyses 12–14 , . 17–31 Two were subdivided into two parts because they analysed four branches of treatment with different durations of eradication therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Most authors currently recommend a 1‐week, twice‐daily course of a proton pump inhibitor (standard dose) and two antibiotics as first‐line therapy for H. pylori infection 3 , . 4 , 10 , 11 Although the proton pump inhibitor is usually administered twice daily, some reports have suggested that schedules using once‐daily, half‐dose proton pump inhibitor are equally effective, 12 , 13 and help to contain costs 14 . There is, however, some concern about whether the reduced proton pump inhibitor dose, and the reduction in acid inhibition that this generates, will lead to a decrease in the eradication rate.…”

Section: Introductionmentioning

confidence: 99%

Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta‐analysis

Vallve

Vergara

Gisbert

et al. 2002

Aliment Pharmacol Ther

121

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Background: Triple therapies combining a double dose of proton pump inhibitor plus two antibiotics are the standard treatment for Helicobacter pylori infection. Some reports suggest that the use of half the dose of proton pump inhibitor is equally effective. Aim: To compare the efficacy of a single vs. double dose of proton pump inhibitor in triple therapy. Methods: We conducted a MEDLINE search. The search strategy included the words (pylori) AND (triple, PPI, proton pump, omeprazole, rabeprazole, pantoprazole, lansoprazole, clarithromycin, amoxicillin, amoxycillin or metronidazole). Abstracts of the articles obtained and papers presented at the European Helicobacter pylori Study Group and American Gastroenterological Association congresses from 1996 to 2001 were examined. Inclusion criteria were: (i) randomized studies with at least two branches of triple therapy including a proton pump inhibitor and two standard antibiotics; (ii) branches could differ only in terms of proton pump inhibitor dosage. A meta‐analysis was conducted using conventional shareware (Review Manager 4.1). Results: Thirteen studies met the inclusion criteria with a total of 2391 patients. Cure rates with double doses of proton pump inhibitor were higher in both the intention‐to‐treat analysis (83.9% vs. 77.7%; Peto odds ratio, 1.51; 95% confidence interval, 1.23–1.85; P < 0.01) and per protocol analysis (89% vs. 81%; Peto odds ratio, 1.96; 95% confidence interval, 1.55–2.47; P < 0.01). Conclusion: Triple therapies containing a single dose of proton pump inhibitor are less effective than those containing a standard double dose of proton pump inhibitor.

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“…and high-dose regimens are employed in China (10). Some studies have indicated that increasing the PPI dose in triple therapy containing omeprazole or lansoprazole can improve the eradication efficacy (14–16), whereas another study reported similar efficacies between low-dose and high-dose rabeprazole in triple-drug therapy (17). Thus, the appropriate dose of rabeprazole for eradication therapy remains controversial.…”

Section: Introductionmentioning

confidence: 99%