Different indocyanine green fluorescence patterns of two skin metastases of hypopharyngeal squamous carcinoma: A case report

Kusada, Takeaki; Yogi, Akira; Hirakawa, Hitoshi; Yasutomi, Yuiko; Aoyama, Hideyasu; Matsuo, Yuji; Oota, Yuka; Zaha, Mayako; Ariga, Toshio; Heianna, Joichi; Murayama, Sadayuki

doi:10.1016/j.pdpdt.2021.102211

Cited by 3 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Response to treatment is also dependent on radiological imaging. A recent advancement in this field is indocyanine green fluorescence angiography (ICG-FA), but some aspects of this modality are still unknown and under study [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis in hypopharyngeal carcinoma: a case report

Shahzad,

Anjum,

Shahid

2024

Asian Biomedicine

View full text Add to dashboard Cite

Background Occurrence of cutaneous metastasis in hypopharyngeal carcinoma is an extremely rare event reported in the literature, with an incidence of only 0.8%–1.3%. Early diagnosis of cutaneous metastasis would have a positive impact on treatment response and disease prognosis with diagnosis mainly dependent on physical examination and radiological imaging (ultrasonography, computed tomography scan or PET-CT). Palliative care is, however, the mainstay of treatment for cutaneous metastasis. Case presentation We report a middle-aged female patient, with known case of hypopharyngeal squamous cell carcinoma, who initially showed partial response to chemoradiotherapy but developed cutaneous nodules in the region of the right axilla and bilateral lateral chest wall posterior to the posterior axillary fold. Excision biopsy of one of these nodules showed metastatic squamous cell carcinoma. The patient was again referred to the Oncology Department of INMOL Hospital and her chemotherapy was planned for cutaneous metastasis. Conclusion Being uncommon, the occurrence of cutaneous lesions in a patient with hypopharyngeal carcinoma should prompt detailed evaluation to rule out metastasis. Early detection will help in improving disease prognosis and median survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis in hypopharyngeal carcinoma: a case report

Shahzad,

Anjum,

Shahid

2024

Asian Biomedicine

View full text Add to dashboard Cite

show abstract

“…Over time, concentration contrast between the tumour and normal tissues develops, resulting in fluorescence intensity (FI) contrast during tissue imaging ( 11 ). ICG has been applied for both clinical diagnosis and treatment, including sentinel lymph node biopsy ( 12 ) and tumour imaging ( 13 ). At the same time, some researchers have used ICG as a diagnostic tool for OSCC.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared fluorescence imaging technology guided margin design in oral squamous cell carcinoma: a single-centre retrospective study

Wang,

Li,

Chi

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveThe margin status of oral squamous cell carcinoma patients is considered to be predictive of recurrence and long-term survival. Therefore, precise intraoperative margin assessment is crucial. This study investigated the feasibility of using near-infrared fluorescence imaging technology to guide margin design in oral squamous cell carcinoma patients.MethodsIn this retrospective study, indocyanine green solution was intravenously injected preoperatively into patients. Intraoperatively, the surgical area was illuminated using a near-infrared fluorescence imaging system, which caused the lesion to fluoresce in the surgical area. Surgery was performed with the assistance of fluorescence imaging. The fluorescence intensity of the lesion area and surrounding normal tissue was recorded during surgery. Intraoperative margins were sent for rapid pathology, and postoperative margin pathology results were documented.ResultsSixteen patients were included in this study (7 males, 9 females), with an average age of 65.65 ± 12.37 years. Preoperative biopsy and postoperative pathology confirmed oral squamous cell carcinoma in all patients. No cancer cells were found in the margin pathology results. The average fluorescence intensity of the lesion area was 214 ± 4.70, and that of the surrounding normal tissue was 104.63 ± 3.14. There was no significant difference in the fluorescence intensity values of the lesion areas among all patients (F=0.38, P>0.05). There was a significant difference in fluorescence intensity between the lesion area and surrounding normal tissue (t=33.76, P<0.05).ConclusionNear-infrared fluorescence imaging technology can aid in real-time imaging differentiation of lesion areas based on differences in fluorescence intensity during surgery. The use of this technology can assist surgeons in assessing the safety margin and reliably guide surgery.

show abstract

“…Compared to other tumors, superficial skin tumors are easier to be observed by ICG fluorescence imaging. Recently, ICG fluorescence imaging has been used for detecting skin metastases of hypopharyngeal squamous carcinoma 22 and sentinel lymph node biopsy in melanoma. 23 This technique may provide a new method to improve the diagnosis and treatment of skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine Green Fluorescence Imaging in the Surgical Management of Skin Squamous Cell Carcinoma

Zhou,

Gan,

et al. 2023

CCID

View full text Add to dashboard Cite

Indocyanine green (ICG) fluorescence imaging has been used in the resection surgery and sentinel lymph node biopsy of many tumors. The aim of the present study is to verify the feasibility and effectiveness of ICG fluorescence imaging used for guiding the biopsy and resection of skin squamous cell carcinoma (SSCC). Methods: Sixty patients were enrolled, including 18 patients of suspected SSCC and 42 patients of diagnosed SSCC on admission. The ICG fluorescence imaging-guided skin biopsy was performed preoperatively in the 18 cases of suspected SSCC. Fifty-three patients underwent ICG fluorescence imaging-guided radical excision. Results:The results showed that 138 skin tissue samples in 60 patients with preoperative or intraoperative ICG fluorescence imagingguide biopsy were collected. For a total number of 138 biopsies, 122 specimens were squamous cell carcinoma, and the accuracy rate was 88.4%, which was significantly higher than that of the group without preoperative ICG fluorescence imaging (41/62, 66.1%, P < 0.05). Fifty-three patients underwent surgery guided with ICG fluorescence imaging. Residual fluorescent signals in 24 patients were intraoperatively found and the excision was then expanded until the signals disappeared. Follow-up to November 2022, 12 patients died, of which 5 cases died from the tumor recurrence, and the others died due to advanced ages or other reasons. The recurrence rate was 9.4%, which was not significantly different from that of the group received routine radical resection (4/35, 11.4%, P > 0.05). Moreover, sentinel lymph nodes were successfully detected under ICG fluorescence imaging in the 4 patients with suspected lymph node metastases, and the location of lymph nodes can be precisely identified. Conclusion: ICG fluorescence imaging technique can guide the pathology biopsy to improve the accuracy of pathological examination, and help to identify the boundaries of tumor tissues and sentinel lymph nodes to resect tumor radically during operation.

show abstract

Different indocyanine green fluorescence patterns of two skin metastases of hypopharyngeal squamous carcinoma: A case report

Cited by 3 publications

References 5 publications

Cutaneous metastasis in hypopharyngeal carcinoma: a case report

Cutaneous metastasis in hypopharyngeal carcinoma: a case report

Near-infrared fluorescence imaging technology guided margin design in oral squamous cell carcinoma: a single-centre retrospective study

Indocyanine Green Fluorescence Imaging in the Surgical Management of Skin Squamous Cell Carcinoma

Contact Info

Product

Resources

About