Different Incidences of Acute Bacterial Meningitis in Children of Central Punjab in Pakistan

Erum, Alia; Zafar, Muhammad Zeeshan; Rasool, Shahid; Ali, Zulfiqar; Yousaf, Kashif; Razzaq, Shakir; Gulbaqir, Hafiz Muhammad; Tariq, Memoona

doi:10.21767/2171-6625.1000231

Cited by 4 publications

(7 citation statements)

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“…Approximately 70% of cases of meningitis occur in children under the age of 5 years and in adults over the age of 60 [11].…”

Section: Introductionmentioning

confidence: 99%

“…More than 90% of ABM cases in the world cause three major pathogens: +LE, Streptococcus pneumoniae (S. pneumonia) and Neisseria meningitidis (N. meningitides). However, the introduction of protein conjugated vaccines against these three pathogens in some countries has changed the epidemiology of bacterial meningitis [3,11,17]. In the United States there is a tendency to reduce morbidity and mortality for pneumococcal and meningococcal meningitis which are associated with the introduction of appropriate vaccination [9].…”

Section: Introductionmentioning

confidence: 99%

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Clinical-epidemiological characteristics of acute bacterial meningitis in children of Khmelnitskyi region (Podilsky region, Ukraine): fifteen-year-long

Pypa¹,

Lysytsia²,

Polishchuk³

et al. 2022

MPU

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Acute bacterial meningitis (ABM) leads to a significant number of complications and high mortality. The aim - to analyze the etiological structure, epidemiological, socio-demographic features and complications in ABM in children of Khmelnitskyi region during 2004-2018. Materials and methods. The analysis of 346 cases of ABM, of which 217 boys and 129 girls was conducted. The etiology of meningitis was determined by bacterioscopy, bacteriological sowing, latex agglutination and polymerase chain reaction. Complications were revealed based on the clinical picture and computed tomography and мagnetic resonance imaging. The processing of the results was carried out using analytical method, t-criterion and constructing 95% confidence interval. Results. The disease started with fever 346 (100%), neck stiffness 289 (83.5%) and vomiting 273 (78.9%), less common, alteration of consciousness 28 (8.1%) and seizures 9 (2.6%). The high level of the cytosis were observed in meningococcal (5801.3±4856.7 cells/mm3) and Hib meningitis (5152.6±4153.1 cells/mm3), the lowest level was in pneumococcal meningitis (2601.0±1839.6 cells/mm3). The highest level of liquor protein was in pneumococcal meningitis (179.0±51.0 mg/dl), and the lowest level was in meningococcal meningitis (102.0±49.0 mg/dl) and Hib meningitis (112.0±56.0 mg/dl). The etiological factor was established in 121 (35.0%) of patients. 52 (15.4%) of patients had neurological complications. Conclusions. The majority (58.1%) of ABM are in children under the age of 3. The main causative agent remains N. meningitidis - 57.9%, the second place is S. pneumoniae - 21.5%, the third Hib - 9.9% of cases. Frequent complications were brain edema 32 (61.5%), seizures 19 (36.5%) and hydrocephalus 8 (15.4%). The study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the children’s parents was obtained for the research. No conflict of interests was declared by the authors.

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“…Approximately 70% of cases of meningitis occur in children under the age of 5 years and in adults over the age of 60 [11].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical-epidemiological characteristics of acute bacterial meningitis in children of Khmelnitskyi region (Podilsky region, Ukraine): fifteen-year-long

Pypa¹,

Lysytsia²,

Polishchuk³

et al. 2022

MPU

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“…Acute bacterial meningitis is a recurrent cause of mortality in all age groups, especially in underdeveloped countries [1,2]. Erum et al reported the highest incidence in neonates than other age groups in Pakistan [1]. It is reported as one of the top 10 causes of infection-related deaths worldwide [1].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Third Generation Cephalosporin-Resistant Klebsiella Meningitis

Zeeshan¹,

Ansari²,

Rehman³

et al. 2022

Cureus

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Acute bacterial meningitis is one of the very common and severe forms of central nervous system (CNS) infection worldwide in almost all age groups. It remains a common cause of mortality, especially in underdeveloped countries, if not treated timely. Detecting an organism from the CSF culture is crucial in the management of acute bacterial meningitis. Selection of antibiotics according to the culture are a very important part of the management. Most commonly involved organisms include Streptococcus pneumoniae, Neisseria meningitides, and Listeria monocytogenes, while other organisms are very uncommon. Here, we report a rare case of Klebsiella pneumoniae meningitis in a young female, which was found resistant to multiple antibiotics including third generation of cephalosporin.

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“…There are three main causative organisms accounting for over 90% of the world cases of ABM. These are Nesseria meningitidis, Streptococcus pneumonia and Hemophilus influenza type b (Hib) [2].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical presentation of ABM is usually different according to the age of patients, the causative bacteria and the duration of symptoms [2]. Neonates often present with nonspecific symptoms such as irritability, poor feeding, respiratory distress, pale or marble skin and hyper-or hypotonia [3,4].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Outcome of Acute Bacterial Meningitis Among Children in Saudi Haospital Hajjah, Northwest Territories of Yemen

Alshehari¹,

Al-Selwi²,

Albahloly³

2018

AJP

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This is a retrospective descriptive study carried out in Saudi Hospital Hajjah between July 2016 and December 2017: The aim of this study is to assess the etiology and outcome of acute bacterial meningitis among children in Saudi Hospital Hajjah. We included in this study all children aged one month or more to 12 years who had symptoms and signs suggested acute bacterial meningitis confirmed by lumber puncture of cerebrospinal fluid for cells, biochemistry and culture. The data of all patients were retrieved from the hospital records and patient`s charts. These data included age, clinical presentation, etiologic microorganism and outcome. A total of 196 patients who had confirmed bacterial meningitis was recorded. Of these, 71 patients (36.2%) were aged under 12 months, 25% aged between 1-2 years old, 17.9% between 3-5 years and 20.9% > 5 years. Cerebrospinal fluid culture was positive among 94.9% of patients. Among the positive isolates, 43.5% were having Nesseria meningitidis, 34.9% Streptococcus pneumonia, 18.2% Hemophillus influenza type b, 2.7% group B Streptococci and 0.5% E.coli. There were 19 patients died giving the case fatality rate as 9.7%. Of those, 47.3% had aged less than 12 months, 31.5% aged 1-2 years, one child (5.2%) aged 4 years and 3 cases (15.8%) were > 5 years. Eleven cases of deaths (57.9%) had s. pneumonia infections. There were 24 patients (12.2%) of survivors developed neurological complications. This study demonstrates that there is no change in the epidemiology of the main causes of acute bacterial meningitis among children compared to that reported prior to introduction Hib and pneumococcal vaccines indicating a limited coverage of vaccination in the Northwest Territories of Yemen. The case fatality rate noted in this study is relatively low, but aggressive efforts by the health care system both to vaccinate and to early treat infected children, meningitis incidence and mortality will decline.

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Different Incidences of Acute Bacterial Meningitis in Children of Central Punjab in Pakistan

Abstract: Background: Acute Bacterial Meningitis (ABM) is a serious public health problem demanding early diagnosis, effective treatment, prevention, and control. Approximately 70 percent of meningitis cases occur in children under the age of 5 and in adults over the age of 60.

Cited by 4 publications

References 0 publications

Clinical-epidemiological characteristics of acute bacterial meningitis in children of Khmelnitskyi region (Podilsky region, Ukraine): fifteen-year-long

Clinical-epidemiological characteristics of acute bacterial meningitis in children of Khmelnitskyi region (Podilsky region, Ukraine): fifteen-year-long

A Rare Case of Third Generation Cephalosporin-Resistant Klebsiella Meningitis

Epidemiology and Outcome of Acute Bacterial Meningitis Among Children in Saudi Haospital Hajjah, Northwest Territories of Yemen

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