“…The interplay of these components shapes the behavioral response to alcohol. Other genes and proteins, that are beyond the scope of this review, have been identified to have played a role in alcohol tolerance, including genes regulating alcohol metabolism (ADH), stress response (e.g., hangover, jwa), circadian rhythm (e.g., tim, per, cyc), histone deacetylase (HDAC), and learning and memory genes [167][168][169][170][171][172][173][174]. They may directly or indirectly be involved in the development and acquisition of tolerance while modulating neuronal plasticity.…”