Different genders should be considered for the extraglycemic benefits of oral antidiabetic drugs

The impact of adding mitomycin-C to radiotherapy plus oral tegafur-uracil on advanced-stage rectal cancer

“…We totally agreed that aged patients and patients with impaired bone marrow function may be at increased risk of poor compliance during the treatment; however, this concept may not be limited to cancer treatment, but also can be applicable to all other chronically ill patients. 2–5 We did not find any data in the current article to support the authors’ recommendation. Moreover, the authors did not mention the cutoff value to define the aged population or provide information about what’s the criteria for identification of impaired bone marrow function.…”

To do one and to get more: Part II. Diabetes and metabolic dysfunction-associated fatty liver diseases

“…[36][37][38] In part I, we try to demonstrate the policy as "To do one and to get more" in the management of complicated diseases, such as DM, and hope that one therapeutic approach can provide more benefits beyond the sugar-lowering effect, 1 but unfortunately, evidence about the impact of ADA on DM and bone health (prevention of osteoporosis and reduction of fracture) seemed to be relatively disappointing, based on failure to show that the use of ADA can satisfy this proposal as "To do one and to get more" concept. 1,[39][40][41] Uncertain conclusions are made after reviewing recent publications from the systemic review and meta-analyses to address the effect of ADA on both DM and bone health. 1,[42][43][44] We still optimized the unlimited potential ability of ADA on ameliorating bone loss (osteoporosis) and preventing fracture, because advance of biomedical technology for ADA can be continuously and uninterruptedly progressed and this dream may come true.…”