1992
DOI: 10.1016/0923-1811(92)90003-t
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Different effects of pemphigus antibody and plasmin on the distribution of keratin intermediate filaments and desmoplakins between cultured oral and epidermal keratinocytes

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Cited by 13 publications
(3 citation statements)
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“…The primary events after binding of pemphigus antibodies to keratinocytes are changes in the cytoskeleton of keratinocytes with retraction of tonofilaments [17][18][19] and breaking of the bond between tonofilaments and desmosomes culminating in shrinkage of the basal cells. 8,[20][21][22] The detachment of tonofilaments occurs before the desmosomes show any visible alteration 8,23 or loss in adhesion.…”
Section: Nondesmosomal Mechanisms Appear To Be Involved In Pv Acanthomentioning
confidence: 99%
“…The primary events after binding of pemphigus antibodies to keratinocytes are changes in the cytoskeleton of keratinocytes with retraction of tonofilaments [17][18][19] and breaking of the bond between tonofilaments and desmosomes culminating in shrinkage of the basal cells. 8,[20][21][22] The detachment of tonofilaments occurs before the desmosomes show any visible alteration 8,23 or loss in adhesion.…”
Section: Nondesmosomal Mechanisms Appear To Be Involved In Pv Acanthomentioning
confidence: 99%
“…First, it has been described that cytokeratin filaments become detached from cell junctions and accumulate in the perinuclear region, a phenomenon commonly referred to as “keratin retraction” (Berkowitz et al 2005 ; Caldelari et al 2001 ; Calkins et al 2006 ; Chernyavsky et al 2007a ; Jinbu et al 1992 ; Kitajima et al 1987 ; Waschke et al 2006 ; Wilgram et al 1961 , 1964 ; Williamson et al 2006 ). It was shown that cytokeratin retraction could be detected as early as 4–6 h after addition of PV-IgG, i.e.…”
Section: Pemphigusmentioning
confidence: 99%
“…This is further emphasized by electron microscopic studies which have shown that the keratinocytes separate first at the interdesmosomal areas even before the loss of adhesion of the desmosomes (Hashimoto & Lever, 1967; Wilgram et al, 1961). The second argument is that studies have shown that the binding of autoantibodies to the respective antigens primarily causes the retraction of tonofilaments causing the cell to decrease in size and gain a rounded morphology (Jinbu et al, 1992; Kitajima et al, 1986). This also occurs before the desmosomes can show any visible alteration.…”
Section: Progression Mechanisms (Split Formation)mentioning
confidence: 99%