Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects

Nam, Su Youn; Park, Bum-Joon; Cho, Yeong-Ah; Ryu, Kum Hei; Choi, Il Ju; Park, Sohee; Kim, Young Woo

doi:10.1007/s00535-016-1282-1

Cited by 29 publications

(26 citation statements)

References 33 publications

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“…34 A large questionnaire-based study from Korea on 11,690 subjects reported that reflux esophagitis had no association with food groups, whereas it was related with male gender, absence of H. pylori, hiatus hernia, high BMI, and total energy intake. 35 Focusing on laryngopharyngeal reflux disease, in Lithuania,…”

Section: Helicobac Ter Pylori a N D G A S Troe Sophag E Al Reflux Dmentioning

confidence: 99%

Helicobacter pylori and nonmalignant upper gastrointestinal diseases

2018

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The review of the most important recent publications concerning the relation of Helicobacter pylori with peptic ulcer disease (PUD), noninvestigated and functional dyspepsia, and gastroesophageal reflux disease (GERD) is presented. H. pylori remains the main etiopathogenetic factor in complicated and uncomplicated PUD. Nevertheless, the role of nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin is increasing. The novel data did not confirm that PUD caused by NSAIDs and aspirin is less symptomatic. The role of glucocorticoids, immunosuppressants, and antidepressants seems to be of some importance. Although the involvement of H. pylori in functional dyspepsia is controversial, several data support the importance of H. pylori-induced gastritis in the pathogenesis of dyspeptic symptoms. Recent interventional studies have reported that H. pylori eradication improves dyspepsia mainly in areas with a high prevalence of this bacterium. Novel data regarding the relation of gastrointestinal peptides, ghrelin and obestatin, with H. pylori infection are also presented. Intriguing findings support the involvement of the gastric microbiota in the causation of chronic functional dyspepsia. Finally, some data concerning negative, positive, or neutral associations of H. pylori with gastroesophageal reflux disease (GERD) were published. In this context, today there is no evidence indicating that H. pylori eradication could worsen the symptoms or the course of GERD.

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Section: Helicobac Ter Pylori a N D G A S Troe Sophag E Al Reflux Dmentioning

confidence: 99%

Helicobacter pylori and nonmalignant upper gastrointestinal diseases

2018

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“…First, most studies did not classify patients with GERD into reflux esophagitis (RE) and NERD. The severity of EAE and response to different meals differed between patients with RE and NERD . The results of studies that enrolled healthy controls only cannot be extrapolated to patients with GERD .…”

Section: Introductionmentioning

confidence: 95%

“…The severity of EAE and response to different meals differed between patients with RE and NERD. [9][10][11] The results of studies that enrolled healthy controls only cannot be extrapolated to patients with GERD. 6,8 In addition, the components of the test meals were variable among the studies.…”

mentioning

confidence: 99%

Effect of high‐fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects

Fan

Hou

Sun

et al. 2018

J of Digest Diseases

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Objectives To investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH. Methods We enrolled patients with reflux esophagitis (RE; n = 15), nonerosive reflux disease (NERD; n = 12) and healthy subjects (n = 10). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 hours. Isocaloric and isovolumetric high‐fat, standard, and functional meals were supplied randomly to the participants. The EAE and gastric acidity of each meal in fasting and postprandial states were compared. Results High‐fat meals significantly increased postprandial EAE in patients with RE and NERD. EAE was higher after a high‐fat meal than after a standard or functional food meals at the fourth hour postprandially in patients with RE (P < 0.05). Patients with NERD reported fewer symptoms after a functional food meal than after high‐fat and standard meals (0 [interquartile range {IQR} 0–1] vs 1 [IQR 0–2] vs 3 [IQR 1–4], P = 0.014). Compared with high‐fat and standard meals, functional food meal significantly decreased gastric acidity in patients with RE. EAE was significantly related to gastric acidity in patients with RE. Conclusions High‐fat meals increased EAE in patients with RE and NERD. Functional food could serve as adjuvant therapy in GERD patients. EAE was related to gastric acidity in RE patients.

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“…[4][5][6][7][8] In a previous large study, many food groups were strongly associated with non-erosive reflux disease (NERD) but not with erosive esophagitis. 9 However, a rare study presented the association between dietary micronutrient and GERD. 4 Although some dietary micronutrients looks to be associated with Barrett's esophagus, 10,11 dietary micronutrients had no effect on GERD.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous study, the effect of dietary food group on erosive esophagitis and NERD had gender differences. 9 Therefore we further analyzed the gender-specific effect of dietary micronutrient on NERD and erosive esophagitis.…”

Section: Introductionmentioning

confidence: 99%

Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis

Nam

Park

Cho

et al. 2019

J Neurogastroenterol Motil

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Background/AimsThe effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD.MethodsA total of 11 690 participants underwent endoscopy and completed 3-day recordings for dietary intake and questionnaires for reflux symptoms from 2004 to 2008. To evaluate the effect of dietary micronutrients on NERD or erosive esophagitis, adjusted regression analysis with odds ratio (OR) and 95% confidence interval (CI) was used. In addition, we performed gender-specific analysis.ResultsPrevalence of NERD and erosive esophagitis was 6.8% and 11.2% in men and 9.1% and 2.4% in women. In adjusted analysis, high intake of vitamin A (OR, 0.78; 95% CI, 0.64–0.96), retinol (OR, 0.73; 95% CI, 0.59–0.90), vitamin B2 (OR, 0.68; 95% CI, 0.54–0.87), vitamin B6 (OR, 0.75; 95% CI, 0.58–0.96), folic acid (OR, 0.77; 95% CI, 0.62–0.96), calcium (OR, 0.66; 95% CI, 0.53–0.82), and iron (OR, 0.68; 95% CI, 0.53–0.87) had an inverse association with NERD. However, erosive esophagitis has no relationship with micronutrients except vitamin C (OR, 0.78; 95% CI, 0.62–0.98). High dietary intake of calcium reduced the risk of NERD in men and high dietary intake of many micronutrients reduced NERD in women.ConclusionsWhile many dietary micronutrients reduced NERD, they had no effect on erosive esophagitis. The effect of micronutrient on NERD was more prominent in women than men.

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Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects

Abstract: While many food groups affected NERD, reflux esophagitis was associated with BMI and total energy intake rather than dietary component. These results may suggest different approaches toward dietary management of NERD and reflux esophagitis.

Cited by 29 publications

References 33 publications

Helicobacter pylori and nonmalignant upper gastrointestinal diseases

Helicobacter pylori and nonmalignant upper gastrointestinal diseases

Effect of high‐fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects

Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis

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