Different Combinations of Glucose Tolerance and Blood Pressure Status and Incident Diabetes, Hypertension, and Chronic Kidney Disease

Derakhshan, Arash; Bagherzadeh‐Khiabani, Farideh; Arshi, Banafsheh; Ramezankhani, Azra; Azizi, Fereidoun; Hadaegh, Farzad

doi:10.1161/jaha.116.003917

Cited by 23 publications

(15 citation statements)

References 50 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…and 15% for increments of 10 mmHg and 5 mmHg for systolic and diastolic BP, respectively. These data were confirmed by two population-based studies: the Gothemburg Primary Prevention Study [4] and Tehran Lipid and Glucose Study [5]. We extended these epidemiological data demonstrating that in a cohort of hypertensives, those with an uncontrolled hypertension had a higher risk of developing T2D.…”

Section: Essential Hypertension and Type 2 Diabetes The Linksupporting

confidence: 70%

Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes

Mancusi

Izzo

Gioia

et al. 2020

High Blood Press Cardiovasc Prev

122

View full text Add to dashboard Cite

Epidemiological studies have documented a high incidence of diabetes in hypertensive patients.Insulin resistance is defined as a less than expected biologic response to a given concentration of the hormone and plays a pivotal role in the pathogenesis of diabetes. However, over the last decades, it became evident that insulin resistance is not merely a metabolic abnormality, but is a complex and multifaceted syndrome that can also affect blood pressure homeostasis. The dysregulation of neurohumoral and neuro-immune systems is involved in the pathophysiology of both insulin resistance and hypertension. These mechanisms induce a chronic low grade of inflammation that interferes with insulin signalling transduction. Molecular abnormalities associated with insulin resistance include the defects of insulin receptor structure, number, binding affinity, and/or signalling capacity. For instance, hyperglycaemia impairs insulin signalling through the generation of reactive oxygen species, which abrogate insulin-induced tyrosine autophosphorylation of the insulin receptor. Additional mechanisms have been described as responsible for the inhibition of insulin signalling, including proteasome-mediated degradation of insulin receptor substrate 1/2, phosphatase-mediated dephosphorylation and kinase-mediated serine/threonine phosphorylation of both insulin receptor and insulin receptor substrates. Insulin resistance plays a key role also in the pathogenesis and progression of hypertension-induced target organ damage, like left ventricular hypertrophy, atherosclerosis and chronic kidney disease. Altogether these abnormalities significantly contribute to the increase the risk of developing type 2 diabetes.

show abstract

Section: Essential Hypertension and Type 2 Diabetes The Linksupporting

confidence: 70%

Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes

Mancusi

Izzo

Gioia

et al. 2020

High Blood Press Cardiovasc Prev

122

View full text Add to dashboard Cite

show abstract

“…To investigate the impact of different combinations of glucose tolerance and BP status on the development of T2DM, 8231 individuals without diabetes at baseline were recruited (23). During a median follow-up of > 10 years, the overall incidence rate for T2DM was 12.2 per 1000 person-years.…”

Section: Resultsmentioning

confidence: 99%

Blood Pressure and Hypertension: Key Findings of the Tehran Lipid and Glucose Study (TLGS)

Abdi

Amouzegar

Tohidi

et al. 2018

Int J Endocrinol Metab

Self Cite

View full text Add to dashboard Cite

ContextHypertension (HTN) is a well-known modifiable risk factor for cardiovascular disease (CVD), chronic kidney disease and mortality. Positive effects of blood pressure (BP) lowering for prevention of CVD and death have been documented in several meta-analyses of randomized controlled trials.Evidence AcquisitionThis review focuses on the key findings derived from the Tehran lipid and glucose study (TLGS) papers on different aspects of BP and HTN.ResultsA prevalence of 23% for HTN has been reported in the TLGS population, aged ≥ 20 years. Over a decade long follow-up, the crude incidence rate (95% CI) of new-onset HTN defined as systolic BP (SBP) ≥ 140 mmHg and/or diastolic BP (DBP) ≥ 90 mmHg, and not using antihypertensive medication was 33.63 (32.0 - 35.3) per 1000 person-years. Age, baseline SBP and body mass index were significant risk factors for development of isolated systolic HTN; regarding isolated diastolic HTN, baseline DBP and waist circumference were recognized as important risk factors whereas age, female gender and marriage were shown to be protective factors. SBP decreased significantly in both diabetic and non-diabetic participants; DBP showed a non-significant decrease in diabetic men and a statistically significant decrease in non-diabetic men. Among women, both those with and without diabetes (DM) generally experienced statistically significant decreases in DBP. Cox proportional hazard models showed that neither SBP nor DBP were associated with incident DM in the total population and in either gender, separately. All BP components were associated with CVD and all-cause mortality in the middle-aged population. Contribution of HTN to cerebrovascular events was also documented in the TLGS participants, aged ≥ 50 years.ConclusionsSeveral important findings regarding BP/HTN have been derived from the TLGS. According to data regarding the prevalence and incidence of preHTN and HTN and their contribution to cardiovascular morbidity and mortality in the TLGS population as a representative sample of Tehranian population, it is recommended that interventions be prioritized for lifestyle modifications for the prevention and appropriate management of preHTN/HTN.

show abstract

“…It is important also to consider the prevalence of classical cardiovascular risk factors in this population: these have also been associated with increased risk of type 2 diabetes and most people who develop type 2 diabetes die ultimately of cardiovascular disease. 55 Table 2 also shows a high prevalence of hypertension and dyslipidaemia among patients with type 2 diabetes. Of concern, 9% of adolescent Kuwaiti girls already had the metabolic syndrome (US definition).…”

Section: Other Cardiovascular Risk Factorsmentioning

confidence: 99%

Prediabetes management in the Middle East, Africa and Russia: Current status and call for action

Khalil

Abdelaziz

Shammary

et al. 2019

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Most data on the burden of diabetes and prediabetes are from countries where local infrastructure can support reliable estimates of the burden of non-communicable diseases. Countries in the Middle East and Africa, together with Russia, have a total population of almost 2 billion, but have been relatively overlooked by authors in this field. We reviewed the prevalence and drivers of prediabetes and diabetes across this large region. A large, and variable, burden of dysglycaemia exists, especially in Middle Eastern and North African countries, associated with high levels of obesity and sedentariness, with a generally lower prevalence in most other parts of Africa. The design and size of studies are highly variable, and more research to quantify the scale of the problem is needed. Local barriers to care relating to issues concerned with gender, consanguinity, lack of understanding of diabetes, lack of understanding of obesity as a health issue, and limited resource at a national level for tracking and intervention for diabetes and other non-communicable diseases. Lifestyle interventions with proven local cost-effectiveness, enhanced access to pharmacologic intervention, and societal interventions to promote better diet and more activity will be an important element in strategies to combat these adverse trends.

show abstract

Different Combinations of Glucose Tolerance and Blood Pressure Status and Incident Diabetes, Hypertension, and Chronic Kidney Disease

Cited by 23 publications

References 50 publications

Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes

Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes

Blood Pressure and Hypertension: Key Findings of the Tehran Lipid and Glucose Study (TLGS)

Prediabetes management in the Middle East, Africa and Russia: Current status and call for action

Contact Info

Product

Resources

About