Different characteristics of critical COVID-19 and thinking of treatment strategies in non-elderly and elderly severe adult patients

Liu, Zhelong; Wu, Dong; Xia, Han; Jiang, Wangyan; Qiu, Lin; Tang, Rui; Yu, Xuefeng

doi:10.1016/j.intimp.2020.107343

Cited by 7 publications

(16 citation statements)

References 27 publications

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“…Laboratory markers of the protein metabolism have evident agerelated bias in COVID-19. The levels of total protein and albumin are significantly higher in younger patients (Zhao et al, 2020;Liu et al, 2021;Peng et al, 2021). Contrarily, in the older patients researchers noted a significantly higher concentration of the end products of the protein and heme metabolism, i.e., urea (Peng et al, 2021), blood urea nitrogen (Zhao et al, 2020;Liu et al, 2021), creatinine (Zhao et al, 2020;Peng et al, 2021), total bilirubin (Zhao et al, 2020;Peng et al, 2021), and direct bilirubin (Zhao et al, 2020).…”

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

“…The levels of total protein and albumin are significantly higher in younger patients (Zhao et al, 2020;Liu et al, 2021;Peng et al, 2021). Contrarily, in the older patients researchers noted a significantly higher concentration of the end products of the protein and heme metabolism, i.e., urea (Peng et al, 2021), blood urea nitrogen (Zhao et al, 2020;Liu et al, 2021), creatinine (Zhao et al, 2020;Peng et al, 2021), total bilirubin (Zhao et al, 2020;Peng et al, 2021), and direct bilirubin (Zhao et al, 2020). However, there are some conflicting findings on the association of the total bilirubin (Liu et al, 2021) and direct bilirubin (Peng et al, 2021) with advancing age.…”

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

“…Contrarily, in the older patients researchers noted a significantly higher concentration of the end products of the protein and heme metabolism, i.e., urea (Peng et al, 2021), blood urea nitrogen (Zhao et al, 2020;Liu et al, 2021), creatinine (Zhao et al, 2020;Peng et al, 2021), total bilirubin (Zhao et al, 2020;Peng et al, 2021), and direct bilirubin (Zhao et al, 2020). However, there are some conflicting findings on the association of the total bilirubin (Liu et al, 2021) and direct bilirubin (Peng et al, 2021) with advancing age. Besides the difference in disease severity, an appreciably higher glomerular filtration rate in the young patients may explain these facts (Liu et al, 2021).…”

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

“…However, there are some conflicting findings on the association of the total bilirubin (Liu et al, 2021) and direct bilirubin (Peng et al, 2021) with advancing age. Besides the difference in disease severity, an appreciably higher glomerular filtration rate in the young patients may explain these facts (Liu et al, 2021).…”

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

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Impact of Age and Sex on COVID-19 Severity Assessed From Radiologic and Clinical Findings

Statsenko

Zahmi

Habuza

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundData on the epidemiological characteristics and clinical features of COVID-19 in patients of different ages and sex are limited. Existing studies have mainly focused on the pediatric and elderly population.ObjectiveAssess whether age and sex interact with other risk factors to influence the severity of SARS-CoV-2 infection.Material and MethodsThe study sample included all consecutive patients who satisfied the inclusion criteria and who were treated from 24 February to 1 July 2020 in Dubai Mediclinic Parkview (560 cases) and Al Ain Hospital (605 cases), United Arab Emirates. We compared disease severity estimated from the radiological findings among patients of different age groups and sex. To analyze factors associated with an increased risk of severe disease, we conducted uni- and multivariate regression analyses. Specifically, age, sex, laboratory findings, and personal risk factors were used to predict moderate and severe COVID-19 with conventional machine learning methods.ResultsNeed for O2 supplementation was positively correlated with age. Intensive care was required more often for men of all ages (p < 0.01). Males were more likely to have at least moderate disease severity (p = 0.0083). These findings were aligned with the results of biochemical findings and suggest a direct correlation between older age and male sex with a severe course of the disease. In young males (18–39 years), the percentage of the lung parenchyma covered with consolidation and the density characteristics of lesions were higher than those of other age groups; however, there was no marked sex difference in middle-aged (40–64 years) and older adults (≥65 years). From the univariate analysis, the risk of the non-mild COVID-19 was significantly higher (p < 0.05) in midlife adults and older adults compared to young adults. The multivariate analysis provided similar findings.ConclusionAge and sex were important predictors of disease severity in the set of data typically collected on admission. Sexual dissimilarities reduced with age. Age disparities were more pronounced if studied with the clinical markers of disease severity than with the radiological markers. The impact of sex on the clinical markers was more evident than that of age in our study.

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Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

Section: Dissimilarities In the Response To Covid-19 Among Age Groupsmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Age and Sex on COVID-19 Severity Assessed From Radiologic and Clinical Findings

Statsenko

Zahmi

Habuza

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Numerous studies have found older age to be associated with higher risk of severe illness, complications, and mortality in COVID-19 2 . Despite that patients aged ≥80 years have distinct clinical features and risk factors, notably multiple comorbidities and polypharmacy 3 , there is little information on this specific population.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 in patients aged 80 years and over during the peaks of the first three pandemic waves at a Spanish tertiary hospital

Cillóniz¹,

Meira²,

Dueñas³

et al. 2021

Pneumon

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Retracted: COVID‐19 mortality and its predictors in the elderly: A systematic review

Dadras

SeyedAlinaghi

Karimi

et al. 2022

Health Science Reports

121

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Background and Aims: Older people have higher rates of comorbidities and may experience more severe inflammatory responses; therefore, are at higher risk of death. Herein, we aimed to systematically review the mortality in coronavirus disease 2019 (COVID-19) patients and its predictors in this age group.Methods: We searched PubMed, Web of Science, and Science Direct using relevant keywords. Retrieved records underwent a two-step screening process consisting of title/abstract and full-text screenings to identify the eligible studies.Results: Summarizing findings of 35 studies demonstrated that older patients have higher mortality rates compared to the younger population. A review of articles revealed that increasing age, body mass index, a male gender, dementia, impairment or dependency in daily activities, presence of consolidations on chest X-ray, hypoxemic respiratory failure, and lower oxygen saturation at admission were risk factors for death. High D-dimer levels, 25-hydroxy vitamin D serum deficiencies, high C-reactive protein (≥5 mg/L) levels plus any other abnormalities of lymphocyte,

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Different characteristics of critical COVID-19 and thinking of treatment strategies in non-elderly and elderly severe adult patients

Cited by 7 publications

References 27 publications

Impact of Age and Sex on COVID-19 Severity Assessed From Radiologic and Clinical Findings

Impact of Age and Sex on COVID-19 Severity Assessed From Radiologic and Clinical Findings

COVID-19 in patients aged 80 years and over during the peaks of the first three pandemic waves at a Spanish tertiary hospital

Retracted: COVID‐19 mortality and its predictors in the elderly: A systematic review

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