Different associations of apolipoprotein E polymorphism with metabolic syndrome by sex in an elderly Chinese population

Tao, Meng Hua; Liu, Jian Wei; LaMonte, Michael J.; Liu, Jing; Wang, Lei; He, Yao; Li, Xiao Ying; Wang, Lu Ning; Ye, Ling

doi:10.1016/j.metabol.2011.03.004

Cited by 21 publications

(12 citation statements)

References 36 publications

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“…reported a positive association between APOE genotype and TC ( P trend: 2 × 10 −152 ), with highest TC in E4 carriers, which support our observations from the LIPGENE cohort ( E 2 < E 3 /E 3 < E 4) 41 . Circulating LDL-C and apo B concentrations were also significantly greater in E4 carriers at baseline compared with E2 carriers, as observed previously in MetS populations 14 . However, there were no differences in baseline plasma FA or dietary fat intake.…”

Section: Discussionsupporting

confidence: 86%

“…Polymorphisms in the APOE gene, rs429358 (Cys112Arg) and rs7412 (Arg158Cys), encode three common alleles, ε2 (Cys122 and Cys158), ε3 (Cys112 and Arg158) and ε4 (Arg112 and Arg158), which combine to form 6 genotypes, ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4 and ε4/ε4. Some scientists have reported a higher incidence of the ε4 allele among MetS subjects 13, 14 . The ε4 allele has been associated with increased TC, LDL-C, coronary artery disease (CAD) mortality and reduced high-density lipoprotein cholesterol (HDL-C) concentrations 12, 15–19 .…”

Section: Introductionmentioning

confidence: 99%

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APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Fallaize

Carvalho-Wells

Tierney

et al. 2017

Sci Rep

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Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Fallaize

Carvalho-Wells

Tierney

et al. 2017

Sci Rep

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“…Although several studies have reported an association between APOE polymorphism and obesity, insulin resistance and the metabolic syndrome, the results are inconsistent [34–36]. We found no association between APOE polymorphism and any of the traditional cardio-vascular risk factors (except lipid levels) including hypertension, diabetes, smoking, BMI, obesity, waist, age and sex.…”

Section: Discussioncontrasting

confidence: 77%

Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans

et al. 2017

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ObjectivesApolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups.We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors.MethodsWe studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects. TaqMan assays were performed to genotype rs7412 and rs429358, the two variants that determine the APOE alleles ε2, ε3 and ε4. The association between APOE genotype and the lipid profile was analysed by comparing ε2 carriers, ε3 homozygotes and ε4 carriers.ResultsThe frequencies of ε2, ε3 and ε4 in the overall sample were 8%, 70% and 22%, respectively. CAD was not associated with APOE polymorphism. The total cholesterol level was higher in ε4 carriers compared with ε2 carriers: 5.07 vs 4.59 mmol/L (P = 0.016). The LDL-cholesterol level was lower in APOE ε2 carriers compared with ε3 homozygotes and ε4 carriers: 2.65 vs 3.03 and 3.17 mmol/L, respectively (p = 0.002). The total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were similar in the three allelic groups. APOE polymorphism was not associated with diabetes, hypertension, waist circumference or body mass index.ConclusionsOur results indicate that APOE gene polymorphism is associated with the lipid profile but not with CAD in Afro-Caribbean people. This lack of association with CAD may be explained by the low atherogenic profile observed in ε4 carriers, which may warrant further investigation.

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“…In a recent study of young Asian Indian patients with acute myocardial infarction, none of the Apo E alleles was associated with a higher prevalence of MetS . In contrast, Tao et al reported that the Ɛ4 allele was associated with a significantly increased risk of MetS in an elderly Chinese male population. The Ɛ4 allele was also reported to be associated with a significantly increased risk of MetS in an Italian population who were nondiabetic and not on lipid‐lowering therapy but presented with a medical history of CVD .…”

Section: Discussionmentioning

confidence: 94%

Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study

Lai

Petrone

Pankow

et al. 2015

Diabetes Metabolism Res

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Objective Metabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, and insulin resistance is a major public health concern in the United States. The effects of Apolipoprotein E (Apo E) polymorphism on MetS are not well established. Methods We conducted a cross-sectional study consisting of 1,551 participants from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study to assess the relation of Apo E polymorphism with the prevalence of MetS. MetS was defined according to the AHA-NHLBI-IDF-WHO Harmonized Criteria. We used generalized estimating equations to estimate adjusted odds ratios for prevalent MetS and the Bonferroni correction to account for multiple testing in the secondary analysis. Results Our study population had a mean age (SD) of 56.5 (11.0) years and 49.7% had MetS. There was no association between the Apo E genotypes and MetS. The multivariable adjusted ORs (95% CI) were 1.00 (reference), 1.26 (0.31-5.21), 0.89 (0.62-1.29), 1.13 (0.61-2.10), 1.13 (0.88-1.47), and 1.87 (0.91-3.85) for the ε3/ε3, ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε4, and ε4/ε4 genotypes, respectively. In a secondary analysis, ε2/ε3 genotype was associated with 41% lower prevalence odds of low HDL [multivariable adjusted ORs (95% CI) = 0.59 (0.36-0.95)] compared to ε3/ε3 genotype. Conclusions Our findings do not support an association between Apo E polymorphism and MetS in a multi-center population based study of predominantly white US men and women.

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Different associations of apolipoprotein E polymorphism with metabolic syndrome by sex in an elderly Chinese population

Cited by 21 publications

References 36 publications

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans

Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study

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