Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study

Abstract

Objective Metabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, and insulin resistance is a major public health concern in the United States. The effects of Apolipoprotein E (Apo E) polymorphism on MetS are not well established. Methods We conducted a cross-sectional study consisting of 1,551 participants from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study to assess the relation of Apo E polymorphism with the prevalence of MetS. MetS was defined according to the AHA-NHLBI-IDF-WHO Harmonized Criteria. We used generalized estimating equations to estimate adjusted odds ratios for prevalent MetS and the Bonferroni correction to account for multiple testing in the secondary analysis. Results Our study population had a mean age (SD) of 56.5 (11.0) years and 49.7% had MetS. There was no association between the Apo E genotypes and MetS. The multivariable adjusted ORs (95% CI) were 1.00 (reference), 1.26 (0.31-5.21), 0.89 (0.62-1.29), 1.13 (0.61-2.10), 1.13 (0.88-1.47), and 1.87 (0.91-3.85) for the ε3/ε3, ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε4, and ε4/ε4 genotypes, respectively. In a secondary analysis, ε2/ε3 genotype was associated with 41% lower prevalence odds of low HDL [multivariable adjusted ORs (95% CI) = 0.59 (0.36-0.95)] compared to ε3/ε3 genotype. Conclusions Our findings do not support an association between Apo E polymorphism and MetS in a multi-center population based study of predominantly white US men and women.

Effects of Moderate Exercise Training On ApoE And ApoCIII In Metabolic Syndrome

“…The decrease we observed in ApoE level after the training program in this group is in line with the results of Onat et al 17 . We could not find any study 19,20 . Son et al 20 state that the polyformism they found in the rs769450 region of the single nucleotide ApoE gene is associated with MetS.…”

Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study

“…Elucidating genetic risk factors for metabolic syndrome remains a challenging task in the prevention and management of the syndrome complex. Studies for the association between genetic variants on the APOE locus and metabolic syndrome are not consistent with some GWASs; some genetic association studies have demonstrated APOE or APOC1 variants associated with the risk of metabolic syndrome [ 58 , 59 , 60 , 61 ], whereas others have reported no evidence of this association [ 62 , 63 , 64 ]. Our results reveal an independent association between APOE rs429358 genotypes and metabolic syndrome.…”

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

“…Findings from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study among participants with a mean age of 56.5 years showed no such association, wherein MetS was defined by the Consensus criteria [ 28 ]. Interestingly, our study also found no association when the Consensus criteria was used (the primary difference between the Consensus and NCEP ATP III criteria is in terms of the waist circumference cut-offs, wherein the former has cut-offs tailored for Asian populations), highlighting the differing conclusions that can be derived when using diverse criteria to diagnose the same condition, even when the change is as small as changing one component out of five.…”