Differences of bone bonding ability and degradation behaviour in vivo between amorphous calcium phosphate and highly crystalline hydroxyapatite coating

Nagano, Masahisa; Nakamura, Takashi; Kokubo, Tadashi; Tanahashi, Mitsuhiko; Ogawa, Masaki

doi:10.1016/0142-9612(95)00357-6

Cited by 197 publications

(124 citation statements)

References 23 publications

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“…Experiments were repeated five times with similar results. Among these materials, hydroxyapatite has been reported by many authors to have excellent biocompatibility and a high hard-tissueforming ability [18][19][20][21][22] . Recently, a high surgical success rate and early postoperative recovery are demanded, but improvements in the surgical technique alone are insufficient to meet these demands.…”

Section: Discussionmentioning

confidence: 99%

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Asami

Nakamura

Takeuchi

et al. 2008

J. Hard Tissue Biology.

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To develop hydroxyapatite that promotes early cure of postoperative tissue, we heat-treated hydroxyapatite and evaluated its pH-increasing effect and Ca release. We also evaluated the effect of heattreated hydroxyapatite on osteoblast differentiation. (1) No marked change was observed regarding the surface morphology or structure of heat-treated hydroxyapatite on SEM. (2) When hydroxyapatite was immersed in physiologic saline, the saline was made more alkaline by heat-treated than non-heat-treated hydroxyapatite. (3) When hydroxyapatite was immersed in physiologic saline, more Ca ions were released from heat-treated than non-heat-treated hydroxyapatite. (4) X-ray diffraction analysis showed a peak of CaO, which is considered to explain the Ca ion release, in heat-treated hydroxyapatite. (5) When osteoblasts were cultured with hydroxyapatite, heat-treated hydroxyapatite prevented the decrease in the number of alkaline phosphatasepositive osteoblasts in the presence of non-heat-treated hydroxyapatite. Thus, heat-treated hydroxyapatite was suggested to promote early cure of postoperative tissue. Detailed analysis of in vivo effects of heat-treated hydroxyapatite is anticipated to make its clinical application possible.

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Section: Discussionmentioning

confidence: 99%

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Asami

Nakamura

Takeuchi

et al. 2008

J. Hard Tissue Biology.

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“…Some metastable compounds, such as calcium-deficient hydroxyapatite (CDHA), oxyhydroxyapatite (OHA), calcium oxide (CaO), a-tricalcium phosphate (a-TCP), b-tricalcium phosphate, and tetra-calcium phosphate (TTCP) have been detected in the coating [230,235]. It has been reported that the amorphous and metastable compounds are more soluble than the crystalline HA [236] thereby accelerating fixation of the implant with the bone and promoting bone remodeling and attachment [237]. However, the coating with amorphous and metastable compounds causes excessive dissolution.…”

mentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,027

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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“…It was stated that the high degradability of ACP facilitated interaction of implant with surrounding bone tissue. The osseointegration of implant increased the mechanical strength of implant; meanwhile, highly crystalline hydroxyapatite-loaded implants were fragile, and their bonding was weak (Nagano et al 1996). Moreover, amorphous calcium phosphate and polymer-based composite scaffolds have been developed for bone tissue engineering applications, and in vitro biomineralization of these matrices have been conducted (Loher et al 2006;Hild et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…However, the exact mechanism is still unknown (Chai et al 2012). Higher resorbability of ACP assists natural process; thus, ACPs are osteoconductive by triggering chemotaxis and osteoinductive by inducing growth factor expression (Nagano et al 1996;Chai et al 2012). Since osseointegration is required in hard tissue engineering applications for longevity of implants, ACPs ensure the bone binding by dissolving rapidly, diffusing into cells, and reacting with collagen protein (Combes and Rey 2010;He et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

et al. 2015

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The present study evaluates the synthesis of biocompatible osteoconductive and osteoinductive nano calcium phosphate (CaP) particles by industrially applied, aerosol-derived flame spray pyrolysis method for biomedical field. Calcium phosphate nanoparticles were produced in a range of calciumto-phosphorus ratio, (1.20-2.19) in order to analyze the morphology and crystallinity changes, and to test the bioactivity of particles. The characterization results confirmed that nanometer-sized, spherical calcium phosphate particles were produced. The average primary particle size was determined as 23 nm by counting more than 500 particles in TEM pictures. XRD patterns, HRTEM, SAED, and SEM analyses revealed the amorphous nature of the asprepared nano calcium phosphate particles at low Ca/P ratios. Increases in the specific surface area and crystallinity were observed with the increasing Ca/P ratio. TGA-DTA analysis showed that the thermally stable crystal phases formed after 700°C. Cell culture studies were conducted with urine-derived stem cells that possess the characteristics of mesenchymal stem cells. Synthesized amorphous nanoparticles did not have cytotoxic effect at 5-50 lg/ml concentration range. Cells treated with the as-prepared nanoparticles had higher alkaline phosphatase (ALP) enzyme activity than control cells, indicating osteogenic differentiation of cells. A slight decrease in ALP activity of cells treated with two highest Ca:P ratios at 50 lg/ml concentration was observed at day 7. The findings suggest that calcium phosphate nanoparticles Guest Editors: Mustafa Culha, Rawil F. Fakhrullin, Ratnesh Lal This article is part of the topical collection on Nanobiotechnology Electronic supplementary material The online version of this article

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Differences of bone bonding ability and degradation behaviour in vivo between amorphous calcium phosphate and highly crystalline hydroxyapatite coating

Cited by 197 publications

References 23 publications

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

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