Differences in Treatment and in Outcomes Between Idiopathic and Secondary Forms of Organizing Pneumonia

Basarakodu, Krishnamohan; Aronow, Wilbert S.; Nair, Chandra K.; Lakkireddy, Dhanunjaya; Kondur, Ashok; Korlakunta, Hema; Valasareddi, Sri Laxmi; Lem, Vincent M.; Schuller, Dan

doi:10.1097/01.pap.0000249905.63211.a1

Cited by 31 publications

(31 citation statements)

References 18 publications

(19 reference statements)

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“…Studies evaluating the distribution of patients with COP and secondary OP by gender have shown no significant difference between the two groups. ( 1 , 10 , 11 ) Of the 36 patients in the present study, 26 (72.2%) were female and 10 (27.8%) were male. With regard to age, studies have shown that OP is most common in the fifth and sixth decades of life.…”

Section: Discussionmentioning

confidence: 53%

Organizing pneumonia: chest HRCT findings

et al. 2015

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OBJECTIVE: To determine the frequency of HRCT findings and their distribution in the lung parenchyma of patients with organizing pneumonia. METHODS: This was a retrospective review of the HRCT scans of 36 adult patients (26 females and 10 males) with biopsy-proven organizing pneumonia. The patients were between 19 and 82 years of age (mean age, 56.2 years). The HRCT images were evaluated by two independent observers, discordant interpretations being resolved by consensus. RESULTS: The most common HRCT finding was that of ground-glass opacities, which were seen in 88.9% of the cases. The second most common finding was consolidation (in 83.3% of cases), followed by peribronchovascular opacities (in 52.8%), reticulation (in 38.9%), bronchiectasis (in 33.3%), interstitial nodules (in 27.8%), interlobular septal thickening (in 27.8%), perilobular pattern (in 22.2%), the reversed halo sign (in 16.7%), airspace nodules (in 11.1%), and the halo sign (in 8.3%). The lesions were predominantly bilateral, the middle and lower lung fields being the areas most commonly affected. CONCLUSIONS: Ground-glass opacities and consolidation were the most common findings, with a predominantly random distribution, although they were more common in the middle and lower thirds of the lungs.

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Section: Discussionmentioning

confidence: 53%

Organizing pneumonia: chest HRCT findings

et al. 2015

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“…The dramatic improvement of pulmonary symptoms and chest CT after steroid therapy is consistent with the results previously published. In a recent publication concerning 57 patients with BOOP, Krishnamohan et al found 59% of complete resolution and 30% of partial resolution after steroid therapy [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

An unusual pulmonary complication of cytomegalovirus infection in a renal transplant recipient

Jacques

Dallocchio

Dickson

et al. 2008

Clinical Kidney Journal

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“…4,41,130 Secondary OP requires treatment of the underlying condition (CTD, infection) or withdrawal of the causative drug or exposure, 41 and may require a shorter treatment if the offending agent has been withdrawn. 131…”

Section: Treatment Corticosteroid Treatmentmentioning

confidence: 99%

Cryptogenic Organizing Pneumonia

Cottin

Cordier

2012

Semin Respir Crit Care Med

141

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Organizing pneumonia (OP) is a pathological pattern defined by the characteristic presence of buds of granulation tissue within the lumen of distal pulmonary airspaces consisting of fibroblasts and myofibroblasts intermixed with loose connective matrix. This pattern is the hallmark of a clinical pathological entity, namely cryptogenic organizing pneumonia (COP) when no cause or etiologic context is found. The process of intraalveolar organization results from a sequence of alveolar injury, alveolar deposition of fibrin, and colonization of fibrin with proliferating fibroblasts. A tremendous challenge for research is represented by the analysis of features that differentiate the reversible process of OP from that of fibroblastic foci driving irreversible fibrosis in usual interstitial pneumonia because they may determine the different outcomes of COP and idiopathic pulmonary fibrosis (IPF), respectively. Three main imaging patterns of COP have been described: (1) multiple patchy alveolar opacities (typical pattern), (2) solitary focal nodule or mass (focal pattern), and (3) diffuse infiltrative opacities, although several other uncommon patterns have been reported, especially the reversed halo sign (atoll sign). Definitive diagnosis is based on (1) a suggestive clinical radiological presentation, (2) the demonstration of the characteristic pathological pattern at lung histopathology, and (3) exclusion of possible causes. Transbronchial biopsies or a transthoracic biopsy may also contribute to the pathological diagnosis. Rapid clinical and imaging improvement is obtained with corticosteroid therapy. Because of the risk of misdiagnosing alternative conditions that may mimic OP, only typical cases may be managed without histopathological confirmation, and patients should be followed with particular attention paid to any clue of alternate diagnosis, especially in case of incomplete response to treatment. Patients and clinicians must be aware of frequent relapses after stopping corticosteroid treatment.

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Differences in Treatment and in Outcomes Between Idiopathic and Secondary Forms of Organizing Pneumonia

Cited by 31 publications

References 18 publications

Organizing pneumonia: chest HRCT findings

Organizing pneumonia: chest HRCT findings

An unusual pulmonary complication of cytomegalovirus infection in a renal transplant recipient

Cryptogenic Organizing Pneumonia

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