An unusual pulmonary complication of cytomegalovirus infection in a renal transplant recipient

Cytomegalovirus pneumonia and Cryptogenic organizing pneumonia following pediatric stem cell transplantation for leukemia

“…A similar association between such CMV infections and alloimmune lung syndromes has been reported in patients taking immunsuppresive medication who have undergone lung or renal transplantation [9,10]. In these cases, previous viral respiratory infections can cause markedly elevated in lammatory cytokines and activated T-cell immunity, leading to alloimmune lung syndromes.…”

“…Alloimmune lung syndrome has also been reported in patients who have undergone allo-HSCT and i) are either tapering or ceasing immunosupressive therapy for GVHD within 100 days after transplantation, and ii) have a history of viral respiratory infections [4]. Some studies suggest that intense immunosuppression instituted to treat acute GVHD or T-cell depleted transplant procedures may help protect against alloimmune lung syndrome in patients who have undergone allo-HSCT [4,[10][11][12]. In parallel with these indings, in our pediatric case, BOOP was detected in the 4 months after CMV pneumonia while she was receiving sirolimus for acute GVHD and steroid was being tapered in combination with T cell immune reconstitution.…”

Post-CMV organizing pneumonia – An unusual presentation 10 years after kidney transplantation

“…A similar case of organizing pneumonia post-CMV was described by Jacques et al . [ 16 ] The patient, however, developed early CMV disease soon after withdrawal of valacyclovir prophylaxis (15 days). A week into intravenous ganciclovir treatment, the patient developed organizing pneumonia.…”