Differences in time to natural conception between women with unexplained infertility and infertile women with minor endometriosis

Akande, Valentine; Hunt, Linda; Cahill, David J; Jenkins, Julian

doi:10.1093/humrep/deh045

Cited by 96 publications

(72 citation statements)

References 41 publications

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“…Endometriosis is considered to be the most intractable cause of female infertility [1,2]. Possible causes of the infertility include poor quality of oocytes and embryos [3], impaired fertilization [4,5], and impaired implantation [6], each of which can be induced by inflammation and oxidative stress in the pelvic cavity [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

Tamura

Takasaki

Nakamura

et al. 2014

Journal of Ovarian Research

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Background: Additional treatment with a gonadotropin-releasing hormone (GnRH) agonist (GnRHa) before IVF-ET (ultralong GnRHa therapy) has been reported to improve the outcome of IVF-ET in endometriosis patients. However, the mechanism of ultralong GnRHa therapy is unclear. It is suggested that inflammatory cytokines and oxidative stress contribute to infertility in endometriosis patients. Therefore, in order to search a possible mechanism of ultralong GnRHa therapy, we investigated the effect of ultralong GnRHa therapy on intrafollicular concentrations of tumor necrosis factor alpha (TNFα), oxidative stress markers, and antioxidants in patients with endometriosis. Methods: Twenty-three infertile women with Stage III or IV endometriosis were recruited for this study. Eleven patients received three courses of GnRHa (1.8 mg s.c. every 28 days), followed by a standard controlled ovarian hyperstimulation (COH) for IVF-ET (ultralong group). The other 12 patients received a standard COH with mid-luteal phase GnRHa down-regulation (control group). The numbers of matured follicles and retrieved oocytes, fertilization rates, implantation rates, clinical pregnancy rate, and intrafollicular concentrations of TNFα, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL) as oxidative stress markers, and melatonin and Cu,Zu-superoxide dismutase (Cu,Zn-SOD) as antioxidants were compared between the two groups.

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Section: Introductionmentioning

confidence: 99%

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

Tamura

Takasaki

Nakamura

et al. 2014

Journal of Ovarian Research

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show abstract

“…Endometriosis is tightly linked to infertility, which is manifested at very early stages of endometriosis [1]. It is easily understandable that moderate to severe [2] endometriosis results in anatomical destruction and distortion in the peritoneal cavity causing infertility.…”

Section: Introductionmentioning

confidence: 99%

Downregulative Effects of Nitric Oxide on Oocyte Fertilization and Embryo Development: Possible Roles of Nitric Oxide in the Pathogenesis of Endometriosis-associated Infertility

Luo

Chen

Ding

et al. 2010

Cell Physiol Biochem

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Aims: To investigate the effects of elevated nitric oxide (NO) levels in peritoneal fluids (PF) on oocyte fertilization and pre-implantation embryo development, and the relation of those effects to endometriosis-associated infertility. Methods: PF from women undergoing laparoscopy for infertility of minor endometriosis, tubal blockage and operation for tubal ligation was aspired at the pouch of the cul-de-sac during surgery. Oocytes and embryos of adult ICR mice were cultured in vitro with or without endometriotic PF. The fertilization rate of oocyte and the cleavage rate of 2-cell embryos were examined. Also, the clinical indexes of IVF-ET of women with minor endometriosis and tubal infertility were analyzed. Results: Oocyte fertilization rate of endometriotic women with IVF-ET treatment was significantly lower than that of tubal block women. The dose-related adverse effects of endometriotic PF and SNP (NO donor) in culture medium on oocyte fertilization and embryos development were confirmed. Conclusion: Increased NO levels in PF play an important role in mediating the effects of endometriotic PF on oocyte fertilization and embryo development. IVF might serve as an alternative treatment for endometriosis-associated infertility.

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“…Certains auteurs sont en faveur de la coelioscopie systématique pour la recherche d'endométriose [21][22][23][24], d'autres opposés à ce geste [25][26][27][28]. Même l'ESHRE dans ses recommandations ne préconise la coelioscopie qu'en cas de symptômes d'endométriose chez les femmes [11].…”

Section: Le Cas De L'endométrioseunclassified

Contre la pratique systématique d’une cœlioscopie dans le bilan d’une infertilité

Merviel

Lourdel

Brzakowski

et al. 2010

Gynécologie Obstétrique & Fertilité

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Differences in time to natural conception between women with unexplained infertility and infertile women with minor endometriosis

Cited by 96 publications

References 41 publications

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis

Downregulative Effects of Nitric Oxide on Oocyte Fertilization and Embryo Development: Possible Roles of Nitric Oxide in the Pathogenesis of Endometriosis-associated Infertility

Contre la pratique systématique d’une cœlioscopie dans le bilan d’une infertilité

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