“…Different forms of heart failure may have one or more of the following: 1) increased neurogenic vasoconstrictor tone (i.e., neuronally released norepinephrine); 2) increased humorally delivered vasoconstrictors (e.g., norepinephrine or angiotensin); and 3) altered vascular smooth muscle reactivity (e.g., enhanced responsiveness to norepinephrine, reduced responsiveness to metabolic vasodilator stimuli). [5][6][7][8][9][10][11] Heart failure of different etiologies may use different compensatory mechanisms. For example, in animal models,5 some types of congestive heart failure (e.g., aortic stenosis with reduced stimulation of carotid arterial baroreceptors) are more likely to result in enhanced neurogenic constrictor tone than others (e.g., pulmonic stenosis, where there is an enhanced vascular constrictor response to norepinephrine).…”