Arterial Baroreflexes in Humans

Mancia, Giuseppe; Mark, Allyn L.

doi:10.1002/cphy.cp020320

Cited by 179 publications

(130 citation statements)

References 276 publications

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“…The fall in these parameters activates the baroreceptors, both the high-pressure arterial baroreceptors and the low-pressure cardiopulmonary baroreceptors. This leads to activation of these negative feedback regulating systems and a subsequent restoration of MAP and venous return towards normal levels (Mancia & Mark, 1983). The FP response is an adapted or modified version of the NP response.…”

Section: Discussionmentioning

confidence: 99%

“…These changes reflect an overall shift in the autonomic balance in favour of the sympathetic system. The net effect is an increase in arterial pressure (Mancia & Mark, 1983).…”

Section: Cardiovascular Regulationmentioning

confidence: 99%

“…The arterial baroreceptors also have a well established influence on the cardiovascular system under orthostatic stress (Mancia & Mark, 1983). The overall effect is also a shift in the autonomic balance, with the sympathetic system becoming more dominant.…”

Section: Cardiovascular Regulationmentioning

confidence: 99%

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Analysis of Time Course Changes in the Cardiovascular Response to Head-Up Tilt in Fighter Pilots

Newman¹,

Callister²

2012

The Cardiovascular System - Physiology, Diagnostics and Clinical Implications

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Section: Discussionmentioning

confidence: 99%

“…These changes reflect an overall shift in the autonomic balance in favour of the sympathetic system. The net effect is an increase in arterial pressure (Mancia & Mark, 1983).…”

Section: Cardiovascular Regulationmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of Time Course Changes in the Cardiovascular Response to Head-Up Tilt in Fighter Pilots

Newman¹,

Callister²

2012

The Cardiovascular System - Physiology, Diagnostics and Clinical Implications

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“…The most commonly used methods for testing baroreflexes in humans are analysis of R-R intervals of the ECG following induction of blood pressure changes by vasoactive drugs or by use of a neck chamber; in the latter case blood pressure reactions can be studied too (Mancia & Mark, 1983). Such studies have shown that chronic resetting, including reduced sensitivity of the baroreflexes is present in hypertension (Bristow, Honour, Pickering, Sleight & Smyth, 1969;Mancia, Ludbrook, Ferrari, Gregorini & Zanchetti, 1978;Zanchetti, 1979).…”

Section: Acute Baroreflex Resetting In Humansmentioning

confidence: 99%

Rapid resetting of human baroreflex working range: insights from sympathetic recordings during acute hypoglycaemia.

Fagius

Berne

1991

The Journal of Physiology

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SUMMARY1. Human muscle nerve sympathetic activity (MSA), which is governed by baroreflexes and involved in blood pressure homeostasis, is increased during acute insulin-induced hypoglyeaemia.2. To elucidate the detailed relationship between MSA and blood pressure during hypoglyeaemia, 0-15 i.u. (kg body weight)-' regular human insulin was given intravenously to eight fasting, healthy volunteers. Microneurographic recording of MSA in the peroneal nerve was made with simultaneous monitoring of arterial blood pressure by a finger cuff (Finapres). The course of MSA and blood pressure was monitored for 30 min before and 60 min after insulin injection. In three subjects control recording without insulin injection was made for the same duration.3. Stimulus-response regression lines were constructed by plotting diastolic blood pressure against the occurrence frequency of MSA for the period of initial rest, the period of maximal MSA outflow during hypoglycaemia and the period of glucose counter-regulation. The control experiments were analysed for the corresponding periods.4. The stimulus-response line was stable throughout the control experiments, whereas it was shifted either to the left or to the right during hypoglyeaemia, and regularly shifted to the left (i.e. towards a lower blood pressure) during glucose counter-regulation, without change of slope.5. It is concluded that the changes in MSA during acute hypoglycaemia are not secondary to baroreflex regulation but instead are characterized by acute resetting of the baroreflex working range without change of sensitivity.

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“…Several recent reports have dampened enthusiasm for at least some of the new inotropic agents [13][14][15][16], so that the role of inotropic stimulation of the fail ing heart remains an open question. In the case of the cardiac glycosides, which have only moderate inotropic effects, beneficial effects in heart failure may be due to their ability to increase baroreceptor sensitivity, and thereby reduce afterload and slow the heart [17,18].…”

Section: Biochemistry: Heart Failure As a Disorder O F The Myocardialmentioning

confidence: 99%

Is Heart Failure an Abnormality of Myocardial Cell Growth?

Katz¹

1990

Cardiology

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Arterial Baroreflexes in Humans

Cited by 179 publications

References 276 publications

Analysis of Time Course Changes in the Cardiovascular Response to Head-Up Tilt in Fighter Pilots

Analysis of Time Course Changes in the Cardiovascular Response to Head-Up Tilt in Fighter Pilots

Rapid resetting of human baroreflex working range: insights from sympathetic recordings during acute hypoglycaemia.

Is Heart Failure an Abnormality of Myocardial Cell Growth?

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