Differences in the chemotype of two native spearmint clonal lines selected for rosmarinic acid accumulation in comparison to commercially grown native spearmint

Narasimhamoorthy, B.; Zhao, Lei; Liu, X.; Yang, Wanling; Greaves, John

doi:10.1016/j.indcrop.2014.10.044

Cited by 16 publications

(17 citation statements)

References 19 publications

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“…The water-extracted dry proprietary spearmint ( M. spicata L. [aerial parts]) extract contained a minimum of 14.5% RA and 24% total polyphenols (Kemin Foods, L.C., Des Moines, IA). 20 , 27–29 In addition, a compositional analysis of this spearmint extract revealed the presence of other polyphenols and their derivatives, including, but not limited to, RA, lithospermic, caftaric, and salvianolic A and B acids. 29 Study capsules contained microcrystalline cellulose (placebo), or 300 or 450 mg of the spearmint extract (Five-Star Pharmacy, Clive, IA).…”

Section: Methodsmentioning

confidence: 93%

“…Spearmint ( Mentha spicata L.) lines were developed through traditional breeding techniques to produce significantly higher levels of bioactive polyphenols, such as RA, 20 to study the effects of these polyphenols on cognitive function. These spearmint lines are distinct from typical commercially available spearmint because they do not contain certain constituents, such as carvone, and they contain 8–9% RA compared with 0–6% RA on a dry weight basis reported for other plants within the Lamiaceae species.…”

Section: Introductionmentioning

confidence: 99%

“…These spearmint lines are distinct from typical commercially available spearmint because they do not contain certain constituents, such as carvone, and they contain 8–9% RA compared with 0–6% RA on a dry weight basis reported for other plants within the Lamiaceae species. 20 , 21 The first indications that the dried aqueous extract from this spearmint could support cognitive performance were obtained by using a senescence accelerated mouse-prone 8 (SAMP8) model of aging. 22 When the spearmint extract was administered to SAMP8 mice for 12 weeks at 320 mg/kg body weight, improvements in learning and memory occurred that corresponded to reduced protein carbonyls and 3-nitrotyrosine in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

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Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment

Herrlinger¹,

Nieman²,

Sanoshy³

et al. 2018

The Journal of Alternative and Complementary Medicine

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Objective: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI).Design: Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System™, Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS™), respectively.Results: Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo.Conclusions: These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI.

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Section: Methodsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment

Herrlinger¹,

Nieman²,

Sanoshy³

et al. 2018

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

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“…Similar findings have been reported by Kivilompolo and Hyötyläinen (2007), who also identified rosmarinic acid as the most abundant phenolic compound, a common finding for aromatic herbs of the Lamiaceae family. In addition, Narasimhamoorthy, Zhao, Liu, Yang, and Greaves (2015) suggested that genotype is a determining factor for rosmarinic acid content of spearmint, which may significantly vary among different genotypes with values ranging from 7.1 to 118 mg/g DW. The results of our study showed that high P application rates may significantly increase rosmarinic acid and total phenols content, even in the case of genotypes that originally contain high amounts of polyphenols.…”

Section: Phenolic Compounds Compositionmentioning

confidence: 99%

Effect of phosphorus application rate on Mentha spicata L. grown in deep flow technique (DFT)

et al. 2019

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The present study evaluated the impact of phosphorus application rate on plant growth and physiological parameters, antioxidant activity, chemical composition, and essential oil yield and composition of hydroponically grown spearmint plants. Increased P levels resulted in high dry matter content of the aerial part. Antioxidant activity of spearmint leaves was significantly higher at the highest P levels. Although essential oil yield was not affected, essential oil composition varied among the studied P levels, especially carvone content. Total and individual organic acids content was higher when 50 mg/L P were added in the nutrient solution. Rosmarinic acid was the main detected phenolic compound, while the highest total phenolic compounds and rosmarinic acid content was observed at 50 and 70 mg/L of P, respectively. In conclusion, phosphorus application rate may affect spearmint growth and development, as well as chemical composition and essential oil composition.

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“…Aqueous extracts from typical commercially grown spearmint lines reportedly contain 0%–6% rosmarinic acid on a dry weight basis [9,10]. However, based on the reported benefits of rosmarinic acid, spearmint lines were developed through selective-breeding techniques to contain higher levels of phenolic compounds such as rosmarinic acid [11]. Therefore, this study aimed to comprehensively characterise the phytochemical profile of a dried aqueous extract from these proprietary spearmint lines.…”

Section: Introductionmentioning

confidence: 99%

Phenolic and Volatile Composition of a Dry Spearmint (Mentha spicata L.) Extract

et al. 2016

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Abstract:The present paper reports a complete mass spectrometric characterization of both the phenolic and volatile fractions of a dried spearmint extract. Phenolic compounds were analysed by ultra-high performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS n ) and a total of 66 compounds were tentatively identified, being the widest phenolic characterisation of spearmint to date. The analysis suggests that the extract is composed of rosmarinic acid and its derivatives (230.5˘13.5 mg/g) with smaller amounts of salvianolic acids, caffeoylquinic acids, hydroxybenzoic acids, hydroxycinnamic acids, flavones, and flavanones. Head space solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) technique, that was applied to characterize the volatile fraction of spearmint, identified molecules belonging to different chemical classes, such as p-cymene, isopiperitone, and piperitone, dihydroedulan II, menthone, p-cymen-8-ol, and β-linalool. This comprehensive phytochemical analysis can be useful to test the authenticity of this product rich in rosmarinic acid and other phenolics, and when assessing its biological properties. It may also be applied to other plant-derived food extracts and beverages containing a broad range of phytochemical compounds.

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Differences in the chemotype of two native spearmint clonal lines selected for rosmarinic acid accumulation in comparison to commercially grown native spearmint

Cited by 16 publications

References 19 publications

Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment

Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment

Effect of phosphorus application rate on Mentha spicata L. grown in deep flow technique (DFT)

Phenolic and Volatile Composition of a Dry Spearmint (Mentha spicata L.) Extract

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