Differences in the Associations Between Memory Complaints and Depressive Symptoms Among Black and White Older Adults

Hill, Nikki L.; Bhargava, Sakshi; Whitaker, Emily; Bhang, Iris; Capuano, Ana W.; Arvanitakis, Zoe; Bennett, David A.; Barnes, Lisa L.

doi:10.1093/geronb/gby091

Cited by 13 publications

(12 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondarily, the present study provides further evidence that cerebrovascular disease risk 10 , depression [11][12][13][14] , and having a family history of memory problems 16 contribute to the reporting of SMCs among AAs. There was also a trend effect on SMC reporting of having a PCP as the referral source.…”

Section: Discussionsupporting

confidence: 57%

“…Additionally, other factors are known to affect the reporting of SMCs among older AAs, including heightened cerebrovascular disease risk 10 , medication regiment 11 , and depression [11][12][13][14] . Although some prior studies have accounted for the above factors that might confound or obscure a relationship between SMC and NTBs, others have not accounted for some other less studied variables that could influence reporting SMCs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Subjective Memory Complaints Are an Important Surrogate for Objective Cognitive Performance in African Americans

Boggess¹,

Barber²,

Jicha

et al. 2019

Alzheimer Disease &Amp; Associated Disorders

View full text Add to dashboard Cite

Purpose: Subjective memory complaints (SMCs) have been shown to be associated with lower neuropsychological test scores cross-sectionally. However, it remains unclear if such findings hold true for African American (AA) older adults.Methods: Baseline visit data from the National Alzheimer's Coordinating Center database collected from September 2005 through March 2018 were used. Generalized linear mixed models specifying binomial distributions were used to examine how neuropsychological test scores affect the likelihood of reporting SMCs.Patients: Inclusion criteria were participants who reported AA as their primary race, 60-80 years of age, were cognitively unimpaired, and had a Mini-Mental Status Exam ≥26. 1021 older AA adults without missing data met the criteria.Results: 258 participants reported a SMC. SMCs were more likely with lower scores on measures of episodic memory and processing; however, SMCs were also more likely with higher scores on a measure of working memory. Working memory appeared to mediate reporting of SMC among participants with lower episodic memory scores.Discussion: These findings demonstrate that SMCs are associated with lower scores on objective neuropsychological measures among older AAs. Additional work is needed to determine if SMCs are further associated with a risk for clinical transition to mild cognitive impairment or dementia among AA older adults.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Subjective Memory Complaints Are an Important Surrogate for Objective Cognitive Performance in African Americans

Boggess¹,

Barber²,

Jicha

et al. 2019

Alzheimer Disease &Amp; Associated Disorders

View full text Add to dashboard Cite

show abstract

“…Consistent with previous work investigating memory concerns in the RUSH cohort, subjective cognitive decline was defined based on two questions examining memory complaints (Barnes et al, 2006;Arvanitakis et al, 2018;Hill et al, 2020). Participants were asked, "About how often do you have trouble remembering things?"…”

Section: Participantsmentioning

confidence: 99%

Subjective Cognitive Decline is a Better Marker for Future Cognitive Decline in Females than in Males

Oliver

Morrison

Kamal

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: The identification of biomarkers and other mechanisms for early detection of Alzheimer's disease is critical to the development and further advancement of therapies and interventions targeted at managing symptoms and tracking the pathophysiology of disease. The endorsement of subjective cognitive decline (SCD) has emerged as a potential indicator of early change in cognitive status that may be predictive of future impairment at a time when measurable declines in neuropsychological performance cannot be detected. While there are numerous findings revealing sex differences in the prevalence of Alzheimer's disease, there is a paucity of research examining sex differences in SCD. Therefore, the goal of this project is to determine if the relationship between the endorsement of SCD and future cognitive changes differ as a function of biological sex. Methods: A sample of 3019 male and female healthy older adults (2188 without SCD, 831 with SCD), with a mean follow-up time of 5.7 years, were included from the Rush Alzheimer's Disease Center Research Sharing Hub. Linear regressions were performed to determine group differences in baseline cognitive scores, while linear mixed effects models were computed to determine group differences in the rate of cognitive change over time. Results: Individuals endorsing SCD had significantly lower baseline cognitive scores and increased rates of decline in all cognitive domains compared to those without SCD. Males exhibited significantly lower scores in baseline performance in global cognition, episodic memory, semantic memory, and perceptual speed regardless of SCD classification. Females with SCD were found to decline at significantly faster rates than both males with SCD and males and females without SCD in all cognitive domains over 15-year follow-up.

show abstract

“…In contrast to objective memory performance, SMC was more strongly related to depressive symptoms, as suggested in prior studies [3, 10, 39, 40]. As a twin study, we were able to examine these relationships beyond the phenotypic level.…”

Section: Discussionmentioning

confidence: 76%

State and trait dimensions of subjective memory concerns: Genetic influences across 30 years

Bell

Beck

Gillespie

et al. 2022

Preprint

View full text Add to dashboard Cite

INTRODUCTION: Genetic influences on the stability of subjective memory concerns (SMC) may confound its interpretation as a state-related risk indicator. METHODS: We estimated genetic influences on SMC and SMC change from average ages 38 to 67, genetic correlations of SMC with memory and depressive symptoms at average ages 56, 62, and 67, and correlations of SMC with polygenic scores for Alzheimers disease and neuroticism, APOE genotype, and parental history or dementia. RESULTS: SMC was highly stable over this 30-year period. Heritability was .51. Phenotypically and genetically, SMC was more strongly related to depressive symptoms than to objective memory. It was also correlated with parental history of dementia and polygenic risk for neuroticism. DISCUSSION: SMCs heritability and stability indicate a substantial trait-like component that is related more to depression and personality than objective memory. Improving it as an indicator of impending cognitive decline or dementia will require isolating its state-related component.

show abstract

Differences in the Associations Between Memory Complaints and Depressive Symptoms Among Black and White Older Adults

Abstract: Abstract Objective To test whether race (specifically Black or White) moderates the relationship between memory complaints and depressive symptoms in cognitively normal older adults, and if these relationships vary by memory complaint characteristics. Methods Data… Show more

Cited by 13 publications

References 49 publications

Subjective Memory Complaints Are an Important Surrogate for Objective Cognitive Performance in African Americans

Subjective Memory Complaints Are an Important Surrogate for Objective Cognitive Performance in African Americans

Subjective Cognitive Decline is a Better Marker for Future Cognitive Decline in Females than in Males

State and trait dimensions of subjective memory concerns: Genetic influences across 30 years

Contact Info

Product

Resources

About