Abstract:INTRODUCTION: Genetic influences on the stability of subjective memory concerns (SMC) may confound its interpretation as a state-related risk indicator.
METHODS: We estimated genetic influences on SMC and SMC change from average ages 38 to 67, genetic correlations of SMC with memory and depressive symptoms at average ages 56, 62, and 67, and correlations of SMC with polygenic scores for Alzheimers disease and neuroticism, APOE genotype, and parental history or dementia.
RESULTS: SMC was highly stable over … Show more
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