Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes

Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium–DMSO complexes containing 2,2′-biimidazole

“…The cytotoxicities of the listed compounds toward the indicated cell lines were determined by MTT assay, as described previously [56]. The percentage of cell viability was calculated using the equation: (mean OD of treated cells/mean OD of control cells) Â 100%.…”

“…The DNA binding study was carried out as previously described [56]. Briefly, the DNA competitive binding with EB was carried out in PBS by keeping [DNA]/[EB] ¼ 5 and varying the concentrations of the ruthenium complexes.…”

Effect of Cu2+ and Fe3+ for drug delivery: Decreased binding affinity of ilaprazole to bovine serum albumin

“…Fe 3 þ is one of the most essential trace elements in human body. Metal ions or their complex can react with serum albumins [16][17][18][19][20], which then can affect the reactions of the drugs and serum albumin. The interactions between serum albumin and a few kinds of drugs, such as flavonoids [21][22][23], vitamins [24] and dexamethasone [25] in the presence of metal ions have been reported.…”

Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes

“…Recently, we have reported the differences in biological properties between two Ru(III) complexes, namely mer-[RuCl 3 (CH 3 CN)(dpq)] and mer-[RuCl 3 (dmso)(dpq)] (dpq = dipyrido[3,2-f:2 0 ,3 0 -h]quinoxaline) [40]. The present study reports the synthesis, characterization and biological properties of a series of Ru(III) complexes containing planar bidentate N-N ligands ( Fig.…”