Differences in serum microRNA profiles in hepatitis B and C virus infection

Akamatsu, Sakura; Hayes, C. Nelson; Tsuge, Masataka; Miki, Daiki; Akiyama, Rie; Abe, Hiromi; Ochi, Hidenori; Hiraga, Nobuhiko; Imamura, Michio; Takahashi, Shoichi; Aikata, Hiroshi; Kawakami, Yoshiiku; Ohishi, Waka; Chayama, Kazuaki

doi:10.1016/j.jinf.2014.10.017

Cited by 52 publications

(52 citation statements)

References 56 publications

(49 reference statements)

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“…Even modest amount of alcohol consumption has been show to elevate serum miR-122 levels51. Pathological states in the liver [NAFDL1828, ALD23 cirrhosis52, cancer29, toxicity53 and infection31] have all been shown to be associated with altered serum/plasma levels of miR-122. In support to our results associating hsa-miR-122-5p levels with liver enzyme levels, the serum levels of miR-122 have been previously shown to be associated with ALT and total cholesterol in hepatitis C patients receiving a nucleic acid-based miR-122 inhibitor54.…”

Section: Discussionmentioning

confidence: 99%

“…Even a serum miRNA expression panel consisting of hsa-miR-122-5p, -1290, -27b-3p, and -192-5p has been suggested for clinical NAFLD diagnostics18. Studies have shown increased levels of circulatory miR-122 in liver diseases with different etiologies18202328293031, indicating that it may be a potential marker for liver injury. In addition, for example the circulatory miRNAs related to inflammation, such as miR-21, -34a, -45128 and -155 have been associated to NAFLD (reviewed in refs 32 and 33).…”

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confidence: 99%

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Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study

Raitoharju

Seppälä

Lyytikäinen

et al. 2016

Sci Rep

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MicroRNAs are involved in disease development and may be utilized as biomarkers. We investigated the association of blood miRNA levels and a) fatty liver (FL), b) lipoprotein and lipid pathways involved in liver lipid accumulation and c) levels of predicted mRNA targets in general population based cohort. Blood microRNA profiling (TaqMan OpenArray), genome-wide gene expression arrays and nuclear magnetic resonance metabolomics were performed for Young Finns Study participants aged 34–49 years (n = 871). Liver fat status was assessed ultrasonographically. Levels of hsa-miR-122-5p and -885-5p were up-regulated in individuals with FL (fold change (FC) = 1.55, p = 1.36 * 10−14 and FC = 1.25, p = 4.86 * 10−4, respectively). In regression model adjusted with age, sex and BMI, hsa-miR-122-5p and -885-5p predicted FL (OR = 2.07, p = 1.29 * 10−8 and OR = 1.41, p = 0.002, respectively). Together hsa-miR-122-5p and -885-5p slightly improved the detection of FL beyond established risk factors. These miRNAs may be associated with FL formation through the regulation of lipoprotein metabolism as hsa-miR-122-5p levels associated with small VLDL, IDL, and large LDL lipoprotein subclass components, while hsa-miR-885-5p levels associated inversely with XL HDL cholesterol levels. Hsa-miR-885-5p levels correlated inversely with oxysterol-binding protein 2 (OSBPL2) expression (r = −0.143, p = 1.00 * 10−4) and suppressing the expression of this lipid receptor and sterol transporter could link hsa-miR-885-5p with HDL cholesterol levels.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study

Raitoharju

Seppälä

Lyytikäinen

et al. 2016

Sci Rep

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“…In addition, they have a role in normal liver development and liver diseases . It was noticed that some viruses may disrupt complex miRNA regulatory networks, resulting in changes in their expression inside and outside of the cell …”

Section: Introductionmentioning

confidence: 99%

Relation between microRNA‐21, transforming growth factor β and response to treatment among chronic hepatitis C patients

Ghazy

Osman

Rashwan

et al. 2019

Journal of Medical Virology

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Background Persistence of hepatitis C virus (HCV) infection and response to antiviral therapy has been shown to be associated with inappropriate levels of cytokines and microRNAs (miRNAs). miRNA levels have been reported to fluctuate during treatment. Thus they could be useful predictors for responses to treatment among HCV infected patients, thereby reducing ineffective treatments. Aim The current study aimed to investigate the relation between miRNA‐21 expression profiles, transforming growth factor β (TGF‐β) serum levels and response to treatment with the new direct antiviral drugs (sofosbuvir + daclatasvir ± ribavirin), among HCV infected Egyptian patients. Subjects and Methods This prospective study was conducted on 50 HCV infected patients (before and after treatment) and 20 healthy volunteers. miRNA expression profiles were determined by real‐time polymerase chain reaction and TGF‐β1 serum levels were measured by using enzyme‐linked immunosorbent assay. Results There was a significant increase in serum albumin, platelets count and a significant decrease in liver enzymes, serum bilirubin, and prothrombin time after treatment. Significant reduction of viral load among HCV patients after receiving the treatment was reported. Concomitantly, there was an increase in the relative quantity of miRNA‐21 (P = .001*) and serum levels of TGF‐β1 ( P = .337) among HCV patients after receiving treatment. Conclusion Nearly all responders to direct antiviral drugs showed increased levels of both miRNA‐21 and TGF‐β1. This may indicate an interplay between TGF‐β1 and miRNA‐21 during remission or progression of viral infection. Thus miRNA‐21 could be used as promising serum biomarker, for assessment of antiviral treatment efficacy and improvement of fibrosis among chronically infected HCV patients.

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“…In a study, it was revealed that increasing level of GGT was significantly related with changes of expression level of miR-22 and miR-1275 (55). In other researches, the abnormal expression levels of these two microRNAs were testified to promote anti-apoptosis and tumor growth (56)(57)(58).…”

Section: Ggt As a Functional Macromolecule In Mechanistic Studiesmentioning

confidence: 99%

Advances of diagnostic and mechanistic studies of γ-glutamyl transpeptidase in hepatocellular carcinoma

Xia

Song

Sun

et al. 2016

DD&T

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Differences in serum microRNA profiles in hepatitis B and C virus infection

Abstract: Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis.

Cited by 52 publications

References 56 publications

Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study

Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study

Relation between microRNA‐21, transforming growth factor β and response to treatment among chronic hepatitis C patients

Advances of diagnostic and mechanistic studies of γ-glutamyl transpeptidase in hepatocellular carcinoma

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