Differences in sensitivity to rocuronium among orbicularis oris muscles innervated by normal or damaged facial nerves and gastrocnemius muscle innervated by somatic nerve in rats

Zhou, Ru-Yuan; Xu, Jing; Chi, Fang‐Lu; Chen, Lianhua; Li, Shitong

doi:10.1002/lary.23286

Cited by 9 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, there are other reports demonstrated that muscle type composition cannot explain the difference in muscle relaxation effect [3,21]. Some researchers drew a conclusion that there was no association between the composition of muscle fiber types and sensitivity to muscle relaxants [21,22]. Zhou et al [21] showed that the orbicularis oris muscle contained fewer type I fibers than the gastrocnemius muscle but displayed more desensitization to rocuronium.…”

Section: Introductionmentioning

confidence: 96%

“…Chen et al [3,20] reported that chronic dexamethasone treatment led to desensitization of the rat DIA to rocuronium and that susceptibility to rocuronium associated with decreased muscle fiber type II. Nevertheless, there are other reports demonstrated that muscle type composition cannot explain the difference in muscle relaxation effect [3,21]. Some researchers drew a conclusion that there was no association between the composition of muscle fiber types and sensitivity to muscle relaxants [21,22].…”

Section: Introductionmentioning

confidence: 96%

“…Zhou et al [21] showed that the orbicularis oris muscle contained fewer type I fibers than the gastrocnemius muscle but displayed more desensitization to rocuronium. The density of AChRs at the end plate and the number of AChRs per unit fiber cross-section area (CSA), AChRs affinity for muscle relaxant may play the most important role in the sensitivity of skeletal muscles to NDMR [21].…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Resistance to rocuronium of rat diaphragm as compared with limb muscles

Huang

Yang

Chen

et al. 2014

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Resistance to rocuronium of rat diaphragm as compared with limb muscles

Huang

Yang

Chen

et al. 2014

Journal of Surgical Research

View full text Add to dashboard Cite

“…Impacts of the facial nerve axotomy can be analyzed in the motor cortex 17,18 . Also, the nerve can be dissected to study Wallerian degeneration 19 or axon regeneration 20 , and the muscles can be removed to study neuromuscular junctions 21 . The facial nerve axotomy can also be used to study the accompanying central and peripheral glial cells 22 , target musculature 21 , and the immune system response 23 .…”

Section: Introductionmentioning

confidence: 99%

“…Also, the nerve can be dissected to study Wallerian degeneration 19 or axon regeneration 20 , and the muscles can be removed to study neuromuscular junctions 21 . The facial nerve axotomy can also be used to study the accompanying central and peripheral glial cells 22 , target musculature 21 , and the immune system response 23 . Although much has been accomplished in studying the facial nerve axotomy model 24 , further study of peripheral nerve injury is required because nerve damage is a significant problem for patients and current treatments fail to produce optimal results.…”

Section: Introductionmentioning

confidence: 99%

Facial Nerve Axotomy in Mice: A Model to Study Motoneuron Response to Injury

Olmstead

Mesnard-Hoaglin

Batka

et al. 2015

JoVE

View full text Add to dashboard Cite

The goal of this surgical protocol is to expose the facial nerve, which innervates the facial musculature, at its exit from the stylomastoid foramen and either cut or crush it to induce peripheral nerve injury. Advantages of this surgery are its simplicity, high reproducibility, and the lack of effect on vital functions or mobility from the subsequent facial paralysis, thus resulting in a relatively mild surgical outcome compared to other nerve injury models. A major advantage of using a cranial nerve injury model is that the motoneurons reside in a relatively homogenous population in the facial motor nucleus in the pons, simplifying the study of the motoneuron cell bodies. Because of the symmetrical nature of facial nerve innervation and the lack of crosstalk between the facial motor nuclei, the operation can be performed unilaterally with the unaxotomized side serving as a paired internal control. A variety of analyses can be performed postoperatively to assess the physiologic response, details of which are beyond the scope of this article. For example, recovery of muscle function can serve as a behavioral marker for reinnervation, or the motoneurons can be quantified to measure cell survival. Additionally, the motoneurons can be accurately captured using laser microdissection for molecular analysis. Because the facial nerve axotomy is minimally invasive and well tolerated, it can be utilized on a wide variety of genetically modified mice. Also, this surgery model can be used to analyze the effectiveness of peripheral nerve injury treatments. Facial nerve injury provides a means for investigating not only motoneurons, but also the responses of the central and peripheral glial microenvironment, immune system, and target musculature. The facial nerve injury model is a widely accepted peripheral nerve injury model that serves as a powerful tool for studying nerve injury and regeneration. Video LinkThe video component of this article can be found at

show abstract

Best Practices in Facial Nerve Monitoring

et al. 2021

View full text Add to dashboard Cite

Objectives/HypothesisFacial nerve monitoring (FNM) has evolved into a widely used adjunct for many surgical procedures along the course of the facial nerve. Even though majority opinion holds that FNM reduces the incidence of iatrogenic nerve injury, there are few if any studies yielding high‐level evidence and no practice guidelines on which clinicians can rely. Instead, a review of the literature and medicolegal cases reveals significant variations in methodology, training, and clinical indications.Study DesignLiterature review and expert opinion.MethodsGiven the lack of standard references to serve as a resource for FNM, we assembled a multidisciplinary group of experts representing more than a century of combined monitoring experience to synthesize the literature and provide a rational basis to improve the quality of patient care during FNM.ResultsOver the years, two models of monitoring have become well‐established: 1) monitoring by the surgeon using a stand‐alone device that provides auditory feedback of facial electromyography directly to the surgeon, and 2) a team, typically consisting of surgeon, technologist, and interpreting neurophysiologist. Regardless of the setting and the number of people involved, the reliability of monitoring depends on the integration of proper technical performance, accurate interpretation of responses, and their timely application to the surgical procedure. We describe critical steps in the technical set‐up and provide a basis for context‐appropriate interpretation and troubleshooting of recorded signals.ConclusionsWe trust this initial attempt to describe best practices will serve as a basis for improving the quality of patient care while reducing inappropriate variations.Level of Evidence4 Laryngoscope, 131:S1–S42, 2021

show abstract

Differences in sensitivity to rocuronium among orbicularis oris muscles innervated by normal or damaged facial nerves and gastrocnemius muscle innervated by somatic nerve in rats

Cited by 9 publications

References 30 publications

Resistance to rocuronium of rat diaphragm as compared with limb muscles

Resistance to rocuronium of rat diaphragm as compared with limb muscles

Facial Nerve Axotomy in Mice: A Model to Study Motoneuron Response to Injury

Best Practices in Facial Nerve Monitoring

Contact Info

Product

Resources

About