Resistance to rocuronium of rat diaphragm as compared with limb muscles

Huang, Lizhen; Yang, Meirong; Chen, Lianhua; Li, Shitong

doi:10.1016/j.jss.2014.07.017

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…However, Ibebunjo suggested that differences in acetylcholine receptor density may not account for the unequal sensitivities of normal muscles to neuromuscular drugs 3 . He concluded that the sensitivity of muscle relaxants varies directly with muscle fiber CSA and inversely with the ESA/CSA ratio 14–16 . That is, muscles with small fibers or large endplates relative to muscle fiber CSA are more sensitive to muscle relaxants, which was consistent with our studies.…”

Section: Discussionmentioning

confidence: 99%

Differences in pharmacodynamic responses to rocuronium in normal or injured orbicularis oris are associated with expression of acetylcholine receptor subunits

Huang

Xing

Wang

et al. 2017

Sci Rep

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Previous research has indicated that differences in sensitivities to muscle relaxants exist between facial nerve- and somatic nerve-innervated muscles. Here, we report that the 50% inhibitory concentration (IC50) values for rocuronium were significantly larger in the normal orbicularis oris than those in the gastrocnemius. Increased IC50 values and reduced twitch tension were observed after facial nerve injury. The normal orbicularis oris had a smaller muscle fiber cross-sectional area (CSA) and a larger ratio of endplate surface area (ESA) to muscle fiber CSA (ESA/CSA), but no difference was found in the density of nicotinic acetylcholine receptor (nAChR) subunits on endplates between normal orbicularis oris and gastrocnemius. Expression of the nAChR α1, β1, δ, ε, and γ subunits increased significantly on the postsynaptic membranes of endplates and extra-junctional muscle membranes after facial nerve injury. Our results suggest that facial nerve-innervated muscle was less sensitive than somatic nerve-innervated muscle, and the mechanisms underlying this result may be related to muscle fiber CSA and the ESA/CSA ratio, but not to the density of nAChR subunits on endplates. Facial nerve injury caused the resistance to neuromuscular blockers and reduced twitch tension, which was related to qualitative, quantitative, and locational changes in nAChR subunits.

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Section: Discussionmentioning

confidence: 99%