Differences in maternal group B Streptococcus screening rates in Latin American countries

HogenEsch, Elena; Mucio, Bremen De; Haddad, Lisa; Vilajeliu, Alba; Ropero, Alba María; Yıldırım, İnci; Omer, Saad B.

doi:10.1016/j.vaccine.2020.10.082

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…Australian women, including public hospital care, care from a general practitioner, private midwife or private obstetrician, shared care and midwife led care (WA Department of Health, 2019). While there has been international research regarding adherence to antenatal GBS screening guidelines (Dalmartello et al, 2019;De Luca et al, 2016;HogenEsch et al, 2020;Kunze et al, 2015;Yamaguchi & Ohashi, 2018), as well as two Australian studies (Braye et al, 2019;Moorhead et al, 2019), only one has been identified with a focus on adherence to GBS screening guidelines specifically within the midwifery led model of care (MMC) (Yamaguchi & Ohashi, 2018).…”

Section: Various Models Of Maternity Care Are Available For Westernmentioning

confidence: 99%

“…The foetus can then acquire the bacteria either in‐utero via vertical transmission during labour (even with membranes intact) or during vaginal birth (Steer et al, 2020). Invasive Early‐Onset Group B Streptococcus Disease (EOGBSD), which occurs from 0 to 7 days of life, can result leading to serious complications for neonates including meningitis, pneumonia and neonatal sepsis, where it continues to be a major cause of morbidity and mortality among term and preterm neonates (HogenEsch et al, 2020). Neonates who survive a GBS infection can suffer from long‐term effects and permanent problems, for example blindness, deafness, moderate‐to‐severe neurological impairments and cerebral palsy (World Health Organization, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Various models of maternity care are available for Western Australian women, including public hospital care, care from a general practitioner, private midwife or private obstetrician, shared care and midwife led care (WA Department of Health, 2019). While there has been international research regarding adherence to antenatal GBS screening guidelines (Dalmartello et al, 2019; De Luca et al, 2016; Gopal Rao, Nartey, et al, 2017; HogenEsch et al, 2020; Kunze et al, 2015; Yamaguchi & Ohashi, 2018), as well as two Australian studies (Braye et al, 2019; Moorhead et al, 2019), only one has been identified with a focus on adherence to GBS screening guidelines specifically within the midwifery led model of care (MMC) (Yamaguchi & Ohashi, 2018). Knowledge is limited regarding the comparison of adherence to GBS screening between pregnant women cared for in different care models, particularly under the MMC, and those cared for under the non‐midwifery led model of care (NMMC).…”

Section: Introductionmentioning

confidence: 99%

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Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Pangerl

Sundin

Geraghty

2022

Journal of Advanced Nursing

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Aims To investigate Group B Streptococcus (GBS) colonization in pregnancy; adherence to antenatal GBS screening and adherence to the intrapartum antibiotics protocol within two models of care (midwifery and non‐midwifery led). Design This retrospective quantitative study has employed a descriptive design using administrative health data. Methods Data from five maternity hospitals in metropolitan and regional Western Australia that included 22,417 pregnant women who gave birth between 2015 and 2019 were examined, applying descriptive statistics using secondary data analysis. Results The study revealed an overall GBS colonization rate of 21.7% with similar rates in the different cohorts. A lower adherence to screening was found in the midwifery led model of care (MMC, 68.76%, n = 7232) when compared with the non‐midwifery led model of care (NMMC, 90.49%, n = 10,767). Over the 5 years, screening rates trended down in the MMC with stable numbers in the counterpart. Adherence in relation to intrapartum antibiotic prophylaxis revealed discrepant findings between the study groups. Conclusion Adherence to screening and management guidelines of maternal GBS colonization in pregnancy is lower within the MMC when compared with the NMMC. Impact This is the first cohort study to describe the adherence to the recommended Western Australian GBS screening guidelines in the two different models of care. Findings may assist in the guidance and improvement of clinical protocols as well as the planning of clinical care in relation to GBS screening to reduce the risk of neonatal GBS infection.

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Section: Various Models Of Maternity Care Are Available For Westernmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Pangerl

Sundin

Geraghty

2022

Journal of Advanced Nursing

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“…Nonetheless, Latin American countries still do not have effective guidelines, and a recent study has shown that less than 15% of pregnant women are, indeed, screened for GBS, except Uruguay, where 65% of them are screened. In the latter country, GBS colonization was found in 18.5% of women, while the highest prevalence was found in black women, older women, and women without primary education ( HogenEsch et al, 2021 ). Considering these data, it is important to highlight the deficiency of data for most Latin American countries.…”

Section: Introductionmentioning

confidence: 99%

Uvaol Prevents Group B Streptococcus-Induced Trophoblast Cells Inflammation and Possible Endothelial Dysfunction

Silva

Botelho

et al. 2021

Front. Physiol.

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Group B Streptococcus (GBS) infection during pregnancy is involved in maternal sepsis, chorioamnionitis, prematurity, fetal infection, neonatal sepsis, and neurodevelopmental alterations. The GBS-induced chorioamnionitis leads to a plethora of immune and trophoblast cells alterations that could influence endothelial cells to respond differently to angiogenic mediators and alter placental vascular structure and function in pregnant women. In this context, preventive measures are needed to reduce such dysfunctions. As such, we evaluated the effects of a non-lethal exposure to inactivated GBS on trophoblast cells and chorionic villi explants, and if the treatment with uvaol would mitigate these effects. The concentration of 106 CFU of GBS was chosen since it was unable to reduce the HTR-8/SVneo cell line nor term chorionic villi explant viability. Raman spectroscopy of trophoblast cells showed significant alterations in their biochemical signature, mostly reverted by uvaol. GBS exposure increased HTR-8/SVneo cells IL-1β and IFN-γ production, phagocytosis, oxidative stress, and decreased trophoblast cell migration. The Ea.hy926 endothelial cell line produced angiopoietin-2, CXCL-8, EGF, FGF-b, IL-6, PlGF, sPECAM-1, and VEGF in culture. When co-cultured in invasion assay with HTR-8/SVneo trophoblast cells, the co-culture had increased production of angiopoietin-2, CXCL-8, FGF-b, and VEGF, while reduced sPECAM-1 and IL-6. GBS exposure led to increased CXCL-8 and IL-6 production, both prevented by uvaol. Chorionic villi explants followed the same patterns of production when exposed to GBS and response to uvaol treatment as well. These findings demonstrate that, even a non-lethal concentration of GBS causes placental inflammation and oxidative stress, reduces trophoblast invasion of endothelial cells, and increases CXCL-8 and IL-6, key factors that participate in vascular dysregulation observed in several diseases. Furthermore, uvaol treatment prevented most of the GBS-provoked changes. Hence, uvaol could prevent the harmful effects of GBS infection for both the mother and the fetus.

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“…Pathogen screening and reporting practices in Latin America in the context of Group B streptococcus (GBS) were addressed by HogenEsch and colleagues [5] . Since infants are uniquely susceptible to GBS-associated mortality and morbidity, intrapartum antibiotic prophylaxis successfully reduces early- but not late-onset infant disease, and the benefits of an effective vaccine for mother and infant are obvious, determining the GBS-associated disease burden is critical in establishing public health priorities.…”

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confidence: 99%

Maternal and neonatal immunization in the Americas: The benefits, the hurdles, and the way forward

Pasetti

Healy

2021

Vaccine

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Differences in maternal group B Streptococcus screening rates in Latin American countries

Cited by 5 publications

References 25 publications

Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Uvaol Prevents Group B Streptococcus-Induced Trophoblast Cells Inflammation and Possible Endothelial Dysfunction

Maternal and neonatal immunization in the Americas: The benefits, the hurdles, and the way forward

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