Differences in &lt;i&gt;Helicobacter pylori&lt;/i&gt; and CagA antibody changes after eradication between subjects developing and not developing gastric cancer

Kodama, Masaaki; Mizukami, Kazuhiro; Fukuda, Kensuke; Ogawa, Ryo; Okamoto, Kazushi; Matsunari, Osamu; Kawahara, Yoshinari; Hirashita, Yuka; Murakami, Kazunari

doi:10.3164/jcbn.19-30

Cited by 5 publications

(3 citation statements)

References 40 publications

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“… 50 Moreover, a higher level of IgG after successful eradication was observed in a gastric cancer group compared to a no-gastric cancer group. 51 Once the association between post-eradication antibody titers for H. pylori and risk of gastric cancer is clarified, measurement of antibody titers after eradication will have a major impact on population health.…”

Section: Discussionmentioning

confidence: 99%

Long-term Response of Helicobacter pylori Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study

Tanaka

Goto

Yamagishi

et al. 2023

Journal of Epidemiology

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Background: Helicobacter pylori (H. pylori) is an established causative factor of gastric cancer. Although the expansion of insurance coverage has led to an increase in the number of patients treated for H. pylori, the population impact of eradication treatment for H.pylori has been scarcely investigated. This study aimed to clarify the long-term responses of H. pylori antibody titer after eradication treatment using large scale cross-sectional data from the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT Study).Methods: A total of 55,282 Japanese participants aged 40 to 74 years residing in 16 areas provided blood samples between 2011 and 2016. From these, treated (n=6,276) and untreated subjects who were seropositive for H. pylori or had serological atrophy (n= 22,420) formed the study population (n=28,696). Seropositivity was defined as an anti-H. pylori IgG titer of ≥10 U/mL. Antibody level was compared among subjects according to self-reported treatment history as untreated, and treated for less than one year (<1Y), one to five years (1-5Y), and more than six years ago (6Y+).

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Section: Discussionmentioning

confidence: 99%

Long-term Response of Helicobacter pylori Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study

Tanaka

Goto

Yamagishi

et al. 2023

Journal of Epidemiology

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“…These tests are thus known to be useful for mass screening of H. pylori infection and risk of GC development. To date, various reports have investigated changes to serum HPIgG and PGs after H. pylori eradication, but each only reported follow-up for up to five years.‍ ( 21 – 26 ) In our previous study, HPIgG were evaluated up to seven years with total 35 patients.‍ ( 27 ) This is the first report to investigate serum HPIgG titer, PG titer, and histological changes simultaneously for more than a decade after eradication using a large number of eradicated patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of long-term serological and histological changes after eradication of Helicobacter pylori

Fukuda

Kodama

Mizukami

et al. 2022

J. Clin. Biochem. Nutr.

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Stratification of gastric cancer risk by measuring serological biomarkers is useful for screening of gastric cancer. However, this method has problem such as overlooking past infected patients. We aimed to evaluate the association between Helicobacter pylori infection status and serological biomarkers. We divided 5,268 patients according to Helicobacter pylori infection status and past infected patients were divided into 12 groups according to time elapsed since eradication. We analyzed mean serum H. pylori immunoglobulin G antibody, pepsinogen titers, histological and endoscopic atrophy score of each group. Mean H. pylori immunoglobulin G antibody showed a decreasing tendency, there was no significant difference from the uninfected group at 11 years after eradication ( p = 0.19). PGI, PGII decreased in short term after eradication. However, both PGI and PGII gradually increased as long-term changes after eradication, became comparable to those in the uninfected group ( p = 0.41, p = 0.37, respectively). Histological atrophy improved gradually, became equivalent to uninfected group. Endoscopic atrophy score did not improve for long term after eradication. In conclusion, patients with long term after eradication reach the uninfected condition serologically, histologically. Endoscopic assessment of gastric mucosal atrophy may be useful for accurate assessment of gastric cancer risk.

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“…( 4 , 5 ) Serological evaluation with anti- H. pylori immunoglobulin G antibody testing is an inexpensive and noninvasive method that is used commonly throughout the world for the diagnosis of H. pylori -related conditions. ( 6 ) The combination of H. pylori antibody and serum pepsinogen has been reported to serve as a useful predictive method for stomach cancer. ( 7 , 8 ) The ABC method classification consists of the following four groups: group A [pepsinogen (–) H. pylori (–)], group B [pepsinogen (–) H. pylori (+)], group C [pepsinogen (+) H. pylori (+)], and group D [pepsinogen (+) H. pylori (–)].…”

Section: Introductionmentioning

confidence: 99%

The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis

Nishizawa

Toyoshima

Kondo

et al. 2021

J. Clin. Biochem. Nutr.

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The ABC method combined with Helicobacter pylori antibody and serum pepsinogen is a useful predictive method for stomach cancer. Kyoto classification is a new grading system for endoscopic gastritis. However, the consistency of the Kyoto score with the ABC method remains unclear. The Kyoto classification score, which ranges from 0 to 8, is based on the following findings: atrophy, intestinal metaplasia, diffuse redness, nodularity, and enlarged folds. Furthermore, we defined a simplified Kyoto classification score as the sum of scores of just atrophy and intestinal metaplasia. The association between the Kyoto classification score and the ABC method was analyzed using the Kruskal-Wallis and Steel-Dwass tests. A total of 307 subjects were enrolled. Kyoto classification scores were similar in groups B, C, and D, while scores in group A were significantly lower than those of the other groups. The simplified Kyoto classification score showed the same stepwise increase as the classification of the ABC method. In conclusion, unlike the Kyoto classification score, the simplified Kyoto score showed the same significant stepwise increase as the classification of the ABC method.

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Differences in <i>Helicobacter pylori</i> and CagA antibody changes after eradication between subjects developing and not developing gastric cancer

Cited by 5 publications

References 40 publications

Long-term Response of <i>Helicobacter pylori</i> Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study

Long-term Response of <i>Helicobacter pylori</i> Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study

Analysis of long-term serological and histological changes after eradication of <i>Helicobacter pylori</i>

The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis

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