Analysis of long-term serological and histological changes after eradication of <i>Helicobacter pylori</i>

Abstract

Stratification of gastric cancer risk by measuring serological biomarkers is useful for screening of gastric cancer. However, this method has problem such as overlooking past infected patients. We aimed to evaluate the association between Helicobacter pylori infection status and serological biomarkers. We divided 5,268 patients according to Helicobacter pylori infection status and past infected patients were divided into 12 groups according to time elapsed since eradication. We analyzed mean serum H. pylori immunoglobulin G antibody, pepsinogen titers, histological and endoscopic atrophy score of each group. Mean H. pylori immunoglobulin G antibody showed a decreasing tendency, there was no significant difference from the uninfected group at 11 years after eradication ( p = 0.19). PGI, PGII decreased in short term after eradication. However, both PGI and PGII gradually increased as long-term changes after eradication, became comparable to those in the uninfected group ( p = 0.41, p = 0.37, respectively). Histological atrophy improved gradually, became equivalent to uninfected group. Endoscopic atrophy score did not improve for long term after eradication. In conclusion, patients with long term after eradication reach the uninfected condition serologically, histologically. Endoscopic assessment of gastric mucosal atrophy may be useful for accurate assessment of gastric cancer risk.

RE.GA.IN.: the Real-world Gastritis Initiative–updating the updates

“…167 168 Existing information rests on serological, endoscopic and histological data obtained from different populations using a vast array of different testing methods. 169 Epidemiological studies support the reliability of assessment of serum PgI and PgI/II ratio as indicators of the functional status of gastric mucosa. 116 170 On this basis, Pg serology has been employed as a functional indicator of post-eradication regression of atrophy.…”

Performing the ABC Method Twice for Gastric Cancer Risk Stratification: A Retrospective Study Based on Data from a Large-Scale Screening Facility

“…High rates of reinfection after H. pylori eradication therapy have been reported in areas with high rates of H. pylori infection; however, the occurrence of new H. pylori infections in adults without a history of H. pylori eradication is unclear [ 16 ]. Recently, it was reported that H. pylori antibody titer and PG level change significantly in the early period after H. pylori eradication, albeit slowly [ 17 ]. However, how much atrophic gastritis has progressed over time in non-infected or currently infected patients in recent years is still unclear.…”