Differences in Immunity to Nematospiroides dubius in Inbred and Outbred Mice

Lueker, David C.; Helper, D I

doi:10.2307/3279135

Cited by 21 publications

(9 citation statements)

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“…On the other hand, it has been considered likely that immune responses have a major influence on parasite survival (Wakelin 1987). The rapid loss of parasites from wood mice in both primary and repeated infection suggests that they resemble 'high responder', rather than 'low responder' mouse genotypes (see Lueker & Hepler 1975;Keymer & Hiorns 1986). The rapid loss of parasites from wood mice in both primary and repeated infection suggests that they resemble 'high responder', rather than 'low responder' mouse genotypes (see Lueker & Hepler 1975;Keymer & Hiorns 1986).…”

Section: The Parasite H Polygyrus Is Of Interest For Two Reasons Fimentioning

confidence: 99%

Genetics, Sex and Exposure: The Ecology of Heligmosomoides polygyrus (Nematoda) in the Wood Mouse

Gregory¹,

Keymer²,

Clarke³

1990

The Journal of Animal Ecology

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. British Ecological Society is collaborating with JSTOR to digitize, preserve and extend access to Journal of Animal Ecology. SUMMARY(1) The population dynamics of the parasitic nematode, Heligmosomoidespolygyrus, in the wood mouse, Apodemus sylvaticus, were investigated.(2) Male wood mice had consistently higher parasite burdens than females exposed to the same number of parasite larvae. The difference was most pronounced in repeated infection. Host age and weight had no effect on parasite population dynamics.(3) The characteristics of parasite survival and fecundity in primary infection are described. There was no evidence of density dependence.(4) The population dynamics of repeated infection demonstrated a reduction in parasite survival proportional to the cumulative number of parasites with which the host had previously been infected. The most likely explanation for this exposure-dependent constraint on parasite population growth is acquired immunity.( 5) Variability in parasite population dynamics between individual wood mice was much greater in repeated infection than in primary infection, indicating that it is the result of heterogeneity in immunocompetence. Low variability between siblings and high variability between families suggests that the heterogeneity has a genetic basis.(6) The results are discussed in the context of the widespread occurrence of H. polygyrus infection in natural A. sylvaticus populations. May 1982). Both the prevalence and the intensity of infection show a high degree of temporal stability. Prevalence is typically above 85% and intensity between ten and twenty-five worms per mouse (Keymer 1985;Keymer & Dobson 1987). Field studies indicate that male wood mice have a consistently higher prevalence and intensity of infection than females, and that both prevalence and intensity show predictable seasonal patterns (Elton et al. 1931 Ecology of a parasitic nematode in wood mice The patterns observed in the population ecology of H. polygyrus in A. sylvaticus illustrate a number of features typical of endemic helminth infection (see Anderson &

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Section: The Parasite H Polygyrus Is Of Interest For Two Reasons Fimentioning

confidence: 99%

Genetics, Sex and Exposure: The Ecology of Heligmosomoides polygyrus (Nematoda) in the Wood Mouse

Gregory¹,

Keymer²,

Clarke³

1990

The Journal of Animal Ecology

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“…Unlike intact BALB/c mice, BALB/c nudes do not develop resistance to reinfection in terms of adult worm expulsion although infected nudes can resist encystment by a small proportion of challenge larvae (Prowse et al 1978). Other data on mouse strain, sex and age effects in the N.dubius/moust system can be found in Cypess & Zidian (1975), Leuker & Hepler (1975), Behnke & Wakelin (1977), Dobson (1961), Dobson & Owen (1978) and Hurley et al (1980). Female BALB/c mice can be vaccinated readily for accelerated rejection of N.dubius by prior implantation of living adult worms.…”

Section: Nematospiroides Dubius: Resistance To Reinfectionmentioning

confidence: 99%

Analysis of Infection Characteristics and Antiparasite Immune Responses in Resistant Compared with Susceptible Hosts

Mitchell¹,

Anders²,

Brown³

et al. 1982

Immunological Reviews

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“…Previous studies of infections of mice with the trichostrongylid H. polygyrus {=Nematospiroides dubius) have indicated that resistance to infection can be acquired following subcutaneous (SC) injection with exsheathed larvae (LUEKER & HEPLER, 1975;CYPESS, 1970) or oral administration of ensheathed larvae (SPURLOCK, 1943;VAN ZANDT, 1961). The development of this resistance following either route of immunization is influenced by the genetic composition of the host (CYPESS & ZIDIAN, 1975).…”

Section: Introductionmentioning

confidence: 99%

The tissue reactions of mice to infection with Heligmosomoides polygyrus

et al. 1988

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The intestines of normal and resistant LAF mice were subjected to histologic study to determine the timing and mechanisms of resistance to reinfection by Heligmosomoides polygyrus. During reinfection third-stage larvae are less able to penetrate the intestinal wall.Larvae which are able to encyst develop at a slower rate and provoke an increase in nonspecific inflammation around their cysts. After emergence from intestinal cysts, preadults are rapidly lost, but at no time were injured or destroyed larvae or adults noted.Exsheathed larvae were injected via tail vein into control, sensitized and resistant BALB/c mice. The inflammatory response around entrapped larvae in the lung was measured at 1, 2, 4, and 8 days. A heightened inflammatory response, consisting primarily of polymorphonuclear cells with some round cells which peaked in size on day 2, was observed in both sensitized and resistant mice. A similar heightened inflammatory response was also observed in both AKR (non-resistant) BALB/c (resistant) mice vaccinated subcutaneously with exsheathed larvae.

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Differences in Immunity to Nematospiroides dubius in Inbred and Outbred Mice

Cited by 21 publications

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Genetics, Sex and Exposure: The Ecology of Heligmosomoides polygyrus (Nematoda) in the Wood Mouse

Genetics, Sex and Exposure: The Ecology of Heligmosomoides polygyrus (Nematoda) in the Wood Mouse

Analysis of Infection Characteristics and Antiparasite Immune Responses in Resistant Compared with Susceptible Hosts

The tissue reactions of mice to infection with Heligmosomoides polygyrus

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