Differences in heart rate variability between depressed and non-depressed elderly

Kooy, K.G. van der; Hout, Hein van; Marwijk, Harm van; Haan, Marten de; Stehouwer, Coen D. A.; Beekman, Aartjan T.F.

doi:10.1002/gps.1439

Cited by 77 publications

(57 citation statements)

References 21 publications

(16 reference statements)

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“…Although, unfortunately, no study has examined the neural associations of latency and maximum bradycardia, the CFT was found to elicit several activity alterations in different CAN structures (Brown, Sanya, & Hilz, 2003;Harper, Macey, Henderson, Woo, Macey, et al, 2003). Interestingly, low vagal response during the CFT was associated with depressed mood (Hughes & Stoney, 2000), indicating an impaired vagal regulation in depression, which is often reported to show increased cortisol concentrations (Wong, Kling, Munson, Listwak, Licinio, et al, 2000) and decreased vagal tone (van der Kooy, van Hout, van Marwijk, de Haan, Stehouwer, & Beekman, 2006). Similar results were found for hostility (Ruiz, Uchino, & Smith, 2006), while an inverse association between anger control and cortisol reactivity was also determined (Gouin, Kiecolt-Glaser, Malarkay, & Glaser, 2008).…”

Section: Discussionmentioning

confidence: 99%

Association between Cold Face Test‐induced vagal inhibition and cortisol response to acute stress

et al. 2011

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Low vagal function is related to several disorders. One possible underlying mechanism linking the vagus nerve and disorders is the HPA axis. Thirty-three healthy male subjects participated in a stress task, while heart rate (HR), respiratory sinus arrhythmia (RSA), salivary cortisol, and mood were assessed. Vagal function was determined using baseline, stress-induced inhibition, and Cold Face Test (CFT)-induced stimulation. The stress task induced a significant increase in cortisol and HR, a decrease in RSA, and a worsening of mood. A linear regression model with the time from CFT onset until maximum bradycardia as the independent variable explained 17.9% of the total variance in cortisol in response to the stressor (mood: 36.5%). The results indicate that a faster CFT response is associated with reduced cortisol increase and enhanced mood after acute stress. Our data support an inverse relationship between vagal function and the HPA axis.

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Section: Discussionmentioning

confidence: 99%

Association between Cold Face Test‐induced vagal inhibition and cortisol response to acute stress

et al. 2011

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“…Heart rate seems to be higher while heart rate variability (HRV) tend to be lower in depressed patients [8]. The reducing HRV and elevated heart rate were associated with depression [9] which have been known to be risk factors for cardiac mobility and mortality [10]. HRV components that are commonly affected by depression are the high-frequency power [11], and the SDNN [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Heart Rate Variability Between Patients With Major Depressive Disorder and Normal Subjects

Chompoopan¹

2018

GEOMATE

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Major Depressive Disorder is one of the major mental health problems that affect the quality of life of the patients. The reduced heart rate variability (HRV) and elevated heart rate that associated with depression have been found as risk factors for cardiac mobility and mortality. These patients should be assessed regularly on HRV parameters and compare with those of normal subjects. This study aimed to compare heart rate variability between patients with the major depressive disorder and normal subjects. This study was conducted at a psychiatric department in Khon Kaen University, Srinagarind Hospital, Khon Kaen province, Thailand. A cross-sectional analytic study design was used. Forty patients diagnosed with the major depressive disorder (who had been treated with antidepressants) were matched according to age, gender with 40 normal subjects participated. They were assessed on HRV for time domain (standard deviation normal to normal: SDNN, and the root mean square of successive differences: RMSSD) and frequency domain (High frequency: HF, low frequency: LF, and LF/HF ratio) using SA 3000P Digital. The results showed that The HRV in the patients and in the normal subjects were found with SDNN 28. 60, 31.44; RMSSD 23.78, 26.73; HF 4.70, 5.04; LF 4.46, 5.01; and LF/HF 1.16, 1.35 respectively. However, No significant difference in the HRV variables between MDD and normal subjects except LF. Findings of this study show that HRV in the treated patients with major depressive disorder seems to be a little lower than the normal subjects. This may be due to the effects of well treated with antidepressants. It is suggested that HRV may be one of the outcome measures for this patient population.

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“…However, some physiological derangements could be implicated as well [10] , including alterations of cardiac autonomic function as assessed by heart rate variability (HRV) analysis. It is known, for example, that elderly patients who suffer from a major depressive disorder have a reduced HRV [11] , and we have recently described HRV alterations related to depression in older adults who have just suffered an acute coronary syndrome [12][13][14] . In fact, CHF and acute coronary syndromes have similar alterations in autonomic function, namely an increase in sympathetic activity and vagal withdrawal, and coronary artery disease is the main cause of CHF [15,16] .…”

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confidence: 99%

Depressive Symptoms Are Related to Decreased Low-Frequency Heart Rate Variability in Older Adults with Decompensated Heart Failure

Guinjoan

Castro²,

Vigo³

et al. 2007

Neuropsychobiology

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Background/Aims: Depression has been associated with increased mortality among individuals with heart failure, but the mechanism for this association is unsettled. Depression is often found to result in autonomic dysfunction which, if present in heart failure, might help explain worsened outcomes. Methods: This study was a cross-sectional evaluation of the relationship between depressive symptoms and cardiac autonomic function, as assessed by short-term heart rate variability (HRV) analysis in aged patients with acute/decompensated heart failure of coronary origin (CHF). A 21-item Hamilton Depression score and measures of short-term HRV were obtained in 31 inpatients ≧65 years of age, 24–72 h after admission to the coronary care unit with a diagnosis of CHF. Results: Clinical depression was present in 22.6% of participants. In the sample as a whole, increasing depressive symptoms were associated with decreased low-frequency HRV. Conclusion: These results may be important in light of recent indications that decreased low-frequency HRV is a predictor of mortality in patients with heart failure.

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Differences in heart rate variability between depressed and non-depressed elderly

Abstract: Older primary care patients with MDD have a reduced HRV. This may explain why depression is a risk factor for cardiovascular disease and mortality.

Cited by 77 publications

References 21 publications

Association between Cold Face Test‐induced vagal inhibition and cortisol response to acute stress

Association between Cold Face Test‐induced vagal inhibition and cortisol response to acute stress

Comparison of Heart Rate Variability Between Patients With Major Depressive Disorder and Normal Subjects

Depressive Symptoms Are Related to Decreased Low-Frequency Heart Rate Variability in Older Adults with Decompensated Heart Failure

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