Differences in current clinical features of diploid and triploid hydatidiform mole

Niemann, Isa; Petersen, Lone Kjeld; Es, Hansen; Sunde, Lone

doi:10.1111/j.1471-0528.2007.01449.x

Cited by 18 publications

(5 citation statements)

References 24 publications

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“…Twenty-one placentas fulfilled this criterion, and of these 20 fulfilled the histopathological criteria for HM. Some observations in the cohort of HMs entering the Danish Mole Project before June 2003 have been published previously (Niemann et al, 2007;Sunde et al, 2011).…”

Section: Methodsmentioning

confidence: 99%

Tetraploidy in hydatidiform moles

et al. 2013

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study question: How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins? summary answer: Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote. The frequency of zygotic tetraploidy was estimated to be 0.7%.what is known already: The parental origin of the genome in tetraploid HMs has only been evaluated in a few cases, most showing three genome sets from the father (PPPM). Estimates of the proportion of HMs that are tetraploid vary between 2 and 28%. study design, size, duration: From 1986 to 2010, unfixed samples of clinically suspected molar pregnancies were forwarded to the Danish Mole Project. For this cohort study 442 samples fulfilled the following criteria for inclusion: macroscopic appearance of HM and ≥10 vesicular chorionic villi with a diameter of ≥1 mm.participants/materials, setting, methods: Of 403 karyotyped samples, 21 cases disclosed ≥2 tetraploid metaphases.The 21 cases were scrutinized by karyotyping, flow cytometry (FC) and DNA-marker analysis.main results and the role of chance: Among 20 HMs, 3 showed the genotype PPPM: one with the sex chromosomes XXYY and two with XXXY, indicating that they originated in tetraploid zygotes. In 14 androgenetic, one likely androgenetic and two mosaics, the tetraploid cells likely developed by endoreduplications of diploid cells. One case did not fulfil the histopathological criteria for HM.limitations, reasons for caution: As an inclusion criterion was the macroscopic observation of vesicular chorionic villi, some non-molar hydropic placentas may have been included and some early moles may have been excluded.wider implications of the findings: In future, studies to determine that an HM is tetraploid and discriminate cases of mosaicism and to deduce the origin of the tetraploidy must use the techniques of karyotyping, DNA-marker analysis and FC in combination. study funding/competing interest(s): No external funding was sought to support this study. None of the authors has any conflict of interest to declare.

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Section: Methodsmentioning

confidence: 99%

Tetraploidy in hydatidiform moles

et al. 2013

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“…In complete hydatidiform mole, the serum hCG level is often >100,000 IU/L at the average diagnosed gestational ages of 11.9 weeks. [ 10 ] In partial hydatidiform mole, the serum hCG is >100,000 IU/L in <10% of cases. [ 11 ] The serum hCG levels in previous and our cases ranged from 7894 to 30,756 IU/L, suggesting that molar CSP could not be diagnosed with serum hCG levels alone.…”

Section: Discussionmentioning

confidence: 99%

Partial molar pregnancy in the cesarean scar

Ling

Zhao²,

Qi³

2018

Medicine

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Rationale:The incidence of molar pregnancy in the cesarean scar is exceedingly low, however, the disease may carry a high risk of uncontrolled hemorrhage or uterine rupture. So far managements of this disease were rarely reported in literature.Patient concerns:We reported a 28-year-old woman presented to our hospital with a complaint of amenorrhea for 48 days and vaginal bleeding for 3 days.Diagnosis:Transvaginal ultrasonography, serum hCG and pelvic MRI confirmed the cesarean scar pregnancy.Interventions:The patient underwent bilateral uterine arterial embolization and suction evacuation.Outcomes:The postoperative histologic examination of the tissue revealed a partial hydatidiform mole.Lessons:Molar pregnancy in the cesarean scar is tough to differentiate from normal cesarean scar pregnancy with serum hCG, sonogram or MRI. This case suggested us that it was necessary to perform a histological examination of postoperative specimen for cesarean scar pregnancy.

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“…In such cases, as 46, However, there are rare cases of tetraploid or biparental diploid complete moles and this is to be considered while evaluating products of conception, as the diagnosis of complete mole should not be excluded based on molecular analysis alone. [16][17][18][19] Accurate diagnosis and classification of molar pregnancy becomes very crucial as the risk of gestational trophoblastic disease including choriocarcinomas is significantly high. The CHM and PHM show 10-30% and 0.5-5 % risk of choriocarcinomas respectively.…”

Section: Discussionmentioning

confidence: 99%

The frequency of hydatidiform mole in a tertiary care hospital from central India

Patil¹,

Gangane²,

Shivkumar³

2020

IJPO

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The gestational trophoblastic disease (GTD) is a group of pregnancy related tumours encompassing complete and partial mole, invasive moles, choriocarcinomas and placental site trophoblastic tumours. Amongst all GTD, hydatidiform moles are the most common form. Hydatidiform mole is a relatively common gynecological condition which could presents like spontaneous abortion, one of the most common gynecological emergencies. Materials and Methods: Present study is a retrospective analysis to determine incidence of hydatidiform mole for eight years duration.All women who were diagnosed of molar pregnancy by estimation of beta hCG and histopathological examination during1st Jan 2010 to 31st Dec 2017 were enrolled in this study. During the study period, there were 84 cases of Molar pregnancy out of 33856 total deliveries. Results: The total number of deliveries reported in the study period was 33856 out of which 84 cases were of gestational trophoblastic disease (GTD). The prevalence of GTD in this tertiary care hospital was 2.48 per 1000 deliveries. During the study period, we had received 55 samples of products of conception and 3079 hysterectomy specimens. Out of 3134 cases, 84 cases were diagnosed as GTD. Out of these 84 cases 81cases were hydatidiform mole. There were two cases of choriocarcinomas and one case of placental site trophoblastic tumour. Conclusion: The prevalence of hydatidiform mole was higher among all entities of gestational trophoblastic disease. The serum beta hCG levels are very sensitive and specific for diagnosis. Histopathological examination is helpful for confirming diagnosis.

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Differences in current clinical features of diploid and triploid hydatidiform mole

Cited by 18 publications

References 24 publications

Tetraploidy in hydatidiform moles

Tetraploidy in hydatidiform moles

Partial molar pregnancy in the cesarean scar

The frequency of hydatidiform mole in a tertiary care hospital from central India

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