The frequency of hydatidiform mole in a tertiary care hospital from central India

Patil, Bharat; Gangane, Nitin; Shivkumar, V. B.

doi:10.18231/j.ijpo.2020.014

Cited by 3 publications

(1 citation statement)

References 33 publications

(37 reference statements)

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“…Among these, Complete and partial hydatidiform mole are the most frequent diseases. 1 Hydatidiform mole is a type of pregnancy with anomalous development of embryo which can be seen on histologic examination as proliferation of trophoblastic cells and formations of fluid filled cavities termed as cistern. 2 Hydatidiform mole is a complication of trophoblastic cells that form the placenta.…”

Section: Introductionmentioning

confidence: 99%

Hydatidiform Mole Types and Age Demographics in Sindh Province, Pakistan

Kainat,

Khan,

Kumar

et al. 2023

PJMHS

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Hydatidiform mole can be classified as partial and complete depending on the clinical and histopathological features. There is regional variation in incidence of hydatidiform mole with more cases seen in Asia, Africa and other developing countries. This cross-sectional descriptive study was done at the department of histopathology in Diagnostic and research laboratory Hyderabad Sindh. A total of 261 cases were added in the study including 251 cases of suction and evacuation and 10 cases of hysterectomy. The mean age was 27.16±6.66 with age range of 17-60 years. In our study out of 260 samples, 155(59.6%) were of complete mole while 105(40.4%) were of partial mole. The incidence of mole was highest in the age group 26-30 years. The prevalence of hydatidiform mole was notably higher in comparison to numerous other studies. In conclusion, it is recommended that all abortion specimens undergo evaluation to prevent misdiagnosis of gestational trophoblastic disease and to ensure appropriate treatment and follow-up, thereby minimizing the risk of complications. Keywords: Hydatidiform mole. Complete mole. Partial mole. Molar pregnancy.

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Section: Introductionmentioning

confidence: 99%

Hydatidiform Mole Types and Age Demographics in Sindh Province, Pakistan

Kainat,

Khan,

Kumar

et al. 2023

PJMHS

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Ruptured large ectopic hydatidiform mole: an infrequent presentation of gestational trophoblastic disease

Aravapalli,

Mane,

Kathrani

et al. 2024

J Ultrasound

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A study on histomorphological analysis of gestational trophoblastic disease

Neral,

Varma,

Grihi

et al. 2024

MGM J Med Sci

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Background: Gestational trophoblastic disease (GTD) represents a diverse group of conditions characterized by abnormal trophoblastic proliferation within the placenta. GTD includes benign and malignant lesions, ranging from complete and partial hydatidiform moles to more severe forms like invasive moles, choriocarcinoma, placental site trophoblastic tumors (PSTTs), and epithelioid trophoblastic tumors. Given that neoplastic GTD lesions respond remarkably well to chemotherapy, early and accurate histopathological diagnosis is crucial as it directly influences treatment and prognosis. Aim and Objectives: This study examined the histomorphological features of various types of GTD alongside key clinical factors such as age, parity, and gestational period. Materials and Methods: The study was conducted in the Department of Pathology over the course of10 years, from January 2014 to January 2024. All cases of GTD confirmed through histopathological examination of hematoxylin and eosin-stained slides were included in the analysis. Results: Out of 60 diagnosed cases of GTD, 34 (56.66%) were complete hydatidiform moles, 22 (36.67%) were partial hydatidiform moles, 1 (1.67%) was an invasive mole, 1 (1.67%) was choriocarcinoma, and 2 (3.33%) were PSTTs. The age of the affected patients ranged from 18 to 45 years, with the highest incidence observed in the 20–25 year age group (30 cases, 50%). Most cases (33, 55%) occurred during the first trimester, with a predominance among primigravida patients (28 cases, 46.66%). The most common clinical presentation was per vaginal bleeding, reported in 56 cases (93.33%). Conclusion: Although GTD can lead to serious complications, including metastasis, it is treatable. In this study, the complete hydatidiform mole was the most frequently encountered lesion and is associated with a higher risk of severe complications such as persistent GTD, invasive moles, and choriocarcinoma. Thus, early and accurate histopathological diagnosis is vital for the timely initiation of therapy, ultimately reducing the mortality rate. This study highlights the various categories and histomorphological features of GTD, emphasizing the importance of understanding its clinical presentation to mitigate disease burden and complications.

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The frequency of hydatidiform mole in a tertiary care hospital from central India

Cited by 3 publications

References 33 publications

Hydatidiform Mole Types and Age Demographics in Sindh Province, Pakistan

Hydatidiform Mole Types and Age Demographics in Sindh Province, Pakistan

Ruptured large ectopic hydatidiform mole: an infrequent presentation of gestational trophoblastic disease

A study on histomorphological analysis of gestational trophoblastic disease

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