Differences in collagen ultrastructure of human first trimester decidua basalis and parietalis: Implications for trophoblastic invasion of the placental bed

Talaulikar, Vikram; Kronenberger, Katrin; Bax, Bridget E.; Moss, R.E.; Manyonda, Isaac

doi:10.1111/jog.12127

Cited by 12 publications

(12 citation statements)

References 17 publications

(34 reference statements)

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“…It is known that this process requires trophoblast pass through ECM and remodeling of ECM. Collagen as an important component of ECM, which is highly expressed at the maternal-fetal interface, must undergo remodeling during trophoblast invasion [89]. Based on the current research, we speculate that, as shown in Figure 1, integrin expressed by trophoblast combines with collagen expressed at the maternal fetal interface to promote trophoblast adhesion.…”

Section: Trophoblast Invasionmentioning

confidence: 66%

Collagen at the maternal-fetal interface in human pregnancy

et al. 2020

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The survival and development of a semi-allogenic fetus during pregnancy require special immune tolerance microenvironment at the maternal fetal interface. During the establishment of a successful pregnancy, the endometrium undergoes a series of changes, and the extracellular matrix (ECM) breaks down and remodels. Collagen is one of the most abundant ECM. Emerging evidence has shown that collagen and its fragment are expressed at the maternal fetal interface. The regulation of expression of collagen is quite complex, and this process involves a multitude of factors. Collagen exerts a critical role during the successful pregnancy. In addition, the abnormal expressions of collagen and its fragments are associated with certain pathological states associated with pregnancy, including recurrent miscarriage, diabetes mellitus with pregnancy, preeclampsia and so on. In this review, the expression and potential roles of collagen under conditions of physiological and pathological pregnancy are systematically discussed.

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Section: Trophoblast Invasionmentioning

confidence: 66%

Collagen at the maternal-fetal interface in human pregnancy

et al. 2020

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“…As a collagenase, MMP-1 is responsible for the degradation of collagen-rich extracellular matrices, such as those abundantly found in the decidua and the myometrium. 45 MMP-1 was reported to be the highest downregulated MMP in PE cases. Specifically, there is a clear reduction in the MMP-1 + EVT population, suggesting its involvement in the reduced invasiveness observed in the pathophysiology of PE.…”

Section: Discussionmentioning

confidence: 98%

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling

et al. 2018

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Preeclampsia (PE) is the leading cause of maternal and neonatal morbidity and mortality. Defects in trophoblast invasion, differentiation of endovascular extravillous trophoblasts (enEVTs), and spiral artery remodeling are key factors in PE development. There are no markers clinically available to predict PE, leaving expedited delivery as the only effective therapy. Dysregulation of miRNA in clinical tissues and maternal circulation have opened a new avenue for biomarker discovery. In this study, we investigated the role of miR-218-5p in PE development. miR-218-5p was highly expressed in EVTs and significantly downregulated in PE placentas. Using first-trimester trophoblast cell lines and human placental explants, we found that miR-218-5p overexpression promoted, whereas anti-miR-218-5p suppressed, trophoblast invasion, EVT outgrowth, and enEVT differentiation. Furthermore, miR-218-5p accelerated spiral artery remodeling in a decidua-placenta co-culture. The effect of miR-218-5p was mediated by the suppression of transforming growth factor (TGF)-β2 signaling. Silencing of TGFB2 mimicked, whereas treatment with TGF-β2 partially reversed, the effects of miR-218-5p. Taken together, these findings demonstrate that miR-218-5p promotes trophoblast invasion and enEVT differentiation through a novel miR-218-5p-TGF-β2 pathway. This study elucidates the role of an miRNA in enEVT differentiation and spiral artery remodeling and suggests that downregulation of miR-218-5p contributes to PE development.

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“…Likewise, fibrinoid is in direct contact with the trophoblast, and fibrin deposits are frequent in contact areas. The collagen fibres in the chorionic villi have a compact structure formed by fibrillar bundles between the vascular wall and the extravascular stroma (Castellucci, Kaufmann, & Bischof, ; Sinai Talaulikar, Kronenberger, Bax, Moss, & Manyonda, ). In the macaque monkey, synthesis and deposition of laminin, fibronectin and type IV collagen occur in basement membranes of distal columnar cells with increasing quantity (Blankenship, Enders, & King, ; Blankenship & King, ; King & Blankenship, ).…”

Section: Haemochorial Placentamentioning

confidence: 99%

Extracellular matrix in epitheliochorial, endotheliochorial and haemochorial placentation and its potential application for regenerative medicine

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Orechio

et al. 2016

Reprod Domestic Animals

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A placenta is defined as structural approximation of maternal and foetal tissues to perform physiological exchange. Associated processes of differentiation and the establishment of its cells take place within the extracellular matrix (ECM) that provides a rich environment of collagens, fibronectins, cytokines and other components. Placental ECM is promising for tissue regeneration purposes, because it has immune tolerance capacities that may cause only minimal rejections of transplants with immunological differences between donor and recipient. However, specific characteristics of ECM during evolution of the structurally very diverse mammalian placenta are not yet revealed. We here address the major aspects of placental types, that is non-invasive (epitheliochorial), medium (endotheliochorial)-to-high (haemochorial) invasive nature of the interhemal barrier between the foetal and maternal blood system as well as their main components of ECM with special reference to species that are commonly used as animal models for human placentation and in the potential applications for regenerative medicine.

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Differences in collagen ultrastructure of human first trimester decidua basalis and parietalis: Implications for trophoblastic invasion of the placental bed

Cited by 12 publications

References 17 publications

Collagen at the maternal-fetal interface in human pregnancy

Collagen at the maternal-fetal interface in human pregnancy

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling

Extracellular matrix in epitheliochorial, endotheliochorial and haemochorial placentation and its potential application for regenerative medicine

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