Differences in clinical manifestations between childhood-onset lupus and adult-onset lupus: a meta-analysis

Livingston, Brieanna; Bonner, Alice D.; Pope, Janet

doi:10.1177/0961203311416694

Cited by 153 publications

(142 citation statements)

References 27 publications

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“…In fact, Muzaffer et al, Hiraki et al, Yalaoui et al and Taddio et al found frequencies of 100%, 100%, 100% and 96% respectively [9,10,13,15]. These results confirm the importance of the detection of ANA despite their low specificity in pediatric SLE [29]. Anti-dsDNA and anti-Sm antibodies are more specific for SLE.…”

Section: Present Study (N=37)supporting

confidence: 75%

Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases

W¹

2014

J Clin Cell Immunol

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Aim: To determine the clinical and serological characteristics in pediatric systemic lupus erythematosus (SLE). Patients and methods:This retrospective study included 37 patients with SLE. All patients fulfilled the ACR revised criteria for SLE and diagnosed between 1994 and 2009. Anti-nuclear antibodies were detected by indirect immunofluorescence (IIF) on liver rat sections. Anti-dsDNA, anti-Sm, anti-nucleosome, anti-SSA, anti-SSB and anti-RNP antibodies were detected by ELISA. Anti-dsDNA antibodies were detected also by IIF on Chrithidia luciliae. Results:The most common signs were anemia (86.5%), proteinuria (73%) and malar rash (67.6%). The frequency of arthritis and photosensitivity were 45.9% and 43.2% respectively. Leucopenia, thrombocytopenia and oral ulcer were present in 37.8%, 32.4% and 18.9% of cases respectively. The frequency of discoid rash was 13.5%. Anti-dsDNA antibodies were detected in 81.1%, anti-Sm and anti-RNP in 56.8%, anti-SSA in 43.2% and anti-SSB in 35.1%. Conclusion:The highest frequency of childhood SLE is situated at the age of puberty. Renal disease is very frequent in paediatric SLE.

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Section: Present Study (N=37)supporting

confidence: 75%

Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases

W¹

2014

J Clin Cell Immunol

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“…3 These symptoms developed only at 13 years of age, 5 months after menarche suggested the role of hormone in the pathogenesis of this disease. Though along with these features, in early age onset SLE, others features such as renal involvement including proteinuria (>500 mg/day), cellular cast, thrombocytopenia, hemolytic anaemia, lymphadenopathy are common 4 , we did not find any other involvement except mild proteinuria that did not fulfill the criteria for diagnosing SLE. The presence of strongly positive anti snRNP may play a role for that in this case as this antibody has been associated with mild renal involvement and a lower prevalence of Raynaud's phenomenon though no history of Raynaud's phenomenon were given.…”

Section: Discussionmentioning

confidence: 60%

Overlap Syndrome in a 13- Year- Old Girl: A Case Report

et al. 2014

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The Overlap Syndrome is a rare condition which comprises two or more connective tissue disease in a same patient. Among them, some are associated with specific autoantibody profile and some are not. Here, we reported a case of overlap syndrome who presented with seizures and features of systemic lupus erythematosus, systemic sclerosis with the presence of strongly positive ANA, Anti snRNP, Anti Scl-70 antibody and weakly positive Anti Sm antibody.DOI: http://dx.doi.org/10.3329/jom.v14i2.19694 J Medicine 2013, 14(2): 218-221

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“…S ystemic lupus erythematosus (SLE) is a multisystem autoimmune disease related to an insuffi ciency in the clearance of cellular materials after apoptosis (1)(2)(3)(4). A recent study suggested that the higher chemokine/cytokine activity during pregnancy in SLE patients increases pregnancyrelated complications and disease fl ares, despite a similar pattern of chemokine/cytokine fl uctuations in healthy pregnant women (5).…”

mentioning

confidence: 99%