Differences in Cerebral Angioarchitectonics in Alzheimer&amp;#39;s Disease in Comparison with Other Neurodegenerative and Ischemic Lesions

Maksimovich, Ivan V.

doi:10.4236/wjns.2018.84036

Cited by 3 publications

(7 citation statements)

References 51 publications

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“…In our earlier studies, we identified vascular and microvascular changes that appear in the brain in AD, which were named dyscirculatory angiopathy of Alzheimer's type (DAAT) 4,7,16 . DAAT relates to cerebral small vessel disease (CSVD) 4,7,[16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Cerebrovascular Changes and Cerebral Atrophy in the Development of Dementia during Alzheimer's Disease

Maksimovich¹

2023

MRAJ

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Background: Alzheimer's disease (AD) is the world's number one cerebral neurodegenerative disease. Up to 80% of all dementia cases are due to this disease. AD occurs not only because of impaired metabolism of amyloid beta (Aβ) and tau protein in cerebral tissue, but also in connection with specific disorders of cerebral blood supply, manifested in dyscirculatory angiopathy of Alzheimer's type (DAAT). Aims: The present research focuses on the clinical discovery of the sequence of development of dyscirculatory angiopathy of Alzheimer's type, cerebral atrophy, and dementia in patients with AD and their immediate family members. Methods: 99 patients were selected for the research, of whom: Test Group 1 93 (93.94%) suffered from various stages of AD and severity of dementia (age 34-79 (mean age 67): 32 (34.40%) men, 61 (65.59%) women). Test Group 2 6 (6.06%) children aged 8-12 with a high probability of inheriting AD. Each of them had a parent diagnosed with AD with mild dementia (TDR-1), and a grandparent diagnosed with AD with moderate (TDR-2) or severe dementia (TDR-3). Each child complained of fatigue, memory loss, difficulty in remembering, difficulty in concentrating, and frequent headaches. Results: Test Group 1. According to the severity of dementia and atrophic changes in the temporal lobes, the patients were subdivided: preclinical stage TDR-0 - 10 (10.75%) people, mild stage AD TDR-1 - 26 (27.96%) people, moderately severe stage AD TDR-2-40 (43.01%) people, severe AD TDR-3 - 17 (18.28%) people. We identified dyscirculatory angiopathy of Alzheimer's type in all patients, regardless of their AD stage. Test Group 2. There were no signs of dementia of cognitive disorders in any case. Initial involutive cerebral changes were detected in all 6 (100%) patients. Phenomena similar to DAAT were detected in all 6 (100%) patients. Conclusion: Cerebrovascular changes manifested by dyscirculatory angiopathy of Alzheimer's type, regardless of the stage of the disease, are observed in all patients with AD, as well as in all their young offspring. These changes affect amyloid beta metabolism in the brain and contribute to its deposition and accumulation in cerebral tissue, which leads to neurodegeneration and AD development. The data obtained indicate that dyscirculatory angiopathy of Alzheimer's type is primary and, moreover, possibly congenital in AD development.

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Section: Introductionmentioning

confidence: 99%

Cerebrovascular Changes and Cerebral Atrophy in the Development of Dementia during Alzheimer's Disease

Maksimovich¹

2023

MRAJ

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“…The etiology of BD has also not been studied in full [22][23][24] . This disease develops its own specific Cerebral small vessel disease (CSVD), which is manifested by subcortical, atherosclerotic lesions of small arterial branches, arterioles and capillaries of the cerebral white matter 6,22,[24][25][26][27][28] . In this BD-specific microcirculatory lesion, the cerebral venous system is less affected than in AD.…”

Section: Introductionmentioning

confidence: 99%

“…In this BD-specific microcirculatory lesion, the cerebral venous system is less affected than in AD. Patients have small subcortical arteriovenous shunts that do not result in venous congestion 27,28 .…”

Section: Introductionmentioning

confidence: 99%

“…Patients develop focal gliosis, which gradually progresses to widespread gliosis and the development of leukoaraiosis [24][25][26] . In BD, widespread subcortical demyelization causes cerebral atrophy, cognitive, mental, motor impairment, and dementia 6,24,25,27,28 .…”

Section: Introductionmentioning

confidence: 99%

“…AD and BD have different etiology and pathogenesis; however, these diseases affect the cerebral microvasculature, though in different ways. As a result, patients progressively develop cerebral neurodegeneration in various ways 27 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study of the Impact of Transcatheter Intracerebral Laser Photobiomodulation Therapy Treatment on Patients with Alzheimer's Disease and Binswanger's Disease

Maksimovich¹

2022

MRAJ

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Background: Alzheimer's disease (AD) and Binswanger's disease (BD) are among the most common neurodegenerative disorders associated with cognitive impairment and dementia. Using energy of lasers with low output power of the red or near-infrared spectrum region called Photobiomodulation Therapy (PBMT), is an achievement in the development of methods for the treatment of these diseases. Aims: The present study investigates the impact of Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT) on the reduction of cognitive, mental impairment and dementia in patients with various Alzheimer's Disease and Binswanger's Disease stages. Methods: For the research, we selected 62 patients suffering from dementia, aged 34-81 (mean age 72.75), 25 men (40.32%), 37 women (59.68%). Test Group 1 - 48 patients previously diagnosed with Alzheimer's Disease. According to dementia severity, patients were subdivided: preclinical stage (dementia level TDR-0) - 4, mild stage (dementia level TDR-1) - 16, moderately severe stage (dementia level TDR-2) - 21, severe stage (dementia level TDR-3) - 7. Test Group 2 - 14 patients with previously diagnosed Binswanger's Disease. According to dementia severity, the patients were subdivided: mild stage (dementia level CDR-1) - 9, moderately severe stage (dementia level CDR-2) - 5. All patients underwent Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT). Results: Test Group 1. Thanks to angiogenesis and neurogenesis stimulation using Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT), in all 48 (100%) cases, cerebral blood supply and microcirculation improved, cerebral involutive and atrophic changes decreased. Patients showed persistently decreasing dementia, cognitive and mental abilities improvement. The vast majority began to correspond to the group with a milder disease stage. Test Group 2. Due to angiogenesis and neurogenesis stimulation, all 14 (100%) cases demonstrated stable dementia reduction, restoration of cognitive, mental functions and daily life activities. Conclusion: Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT) is an effective, physiologically based method of stimulating cerebral angiogenesis and neurogenesis for Alzheimer's Disease and Binswanger's Disease patients. Due to complex laser exposure, patients show cerebral collateral and capillary revascularization, tissue metabolism improvement and cerebral regenerative processes development. Clinically, this leads to stable dementia level decrease, cognitive functions restoration and improvement in patients’ quality of life. The resulting clinical effect lasts for many years.

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Intracerebral Transcatheter Laser Photobiomodulation Therapy in the Treatment of Binswanger's Disease and Vascular Parkinsonism: Research and Clinical Experience

Maksimovich¹

2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Differences in Cerebral Angioarchitectonics in Alzheimer's Disease in Comparison with Other Neurodegenerative and Ischemic Lesions

Cited by 3 publications

References 51 publications

Cerebrovascular Changes and Cerebral Atrophy in the Development of Dementia during Alzheimer's Disease

Cerebrovascular Changes and Cerebral Atrophy in the Development of Dementia during Alzheimer's Disease

Study of the Impact of Transcatheter Intracerebral Laser Photobiomodulation Therapy Treatment on Patients with Alzheimer's Disease and Binswanger's Disease

Intracerebral Transcatheter Laser Photobiomodulation Therapy in the Treatment of Binswanger's Disease and Vascular Parkinsonism: Research and Clinical Experience

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