“…The development of effective strategies for the prevention of accidents/emergencies in mountain sports requires, beside updated knowledge derived from observational (epidemiological) studies, the inclusion of up-to-date findings from basic research. For example, information on cardiovascular and musculo-skeletal strain during hiking, climbing, skiing, cycling, etc., under different ambient conditions (e.g., altitude, cold, heat) is extremely helpful to advise healthy and in particular diseased individuals on the selection of and how to prepare for mountain sports activities [ 10 , 11 , 12 , 13 , 14 ]. Furthermore, knowledge on pathophysiological mechanisms triggering high-altitude illnesses (e.g., acute mountain sickness, high-altitude cerebral and pulmonary edema) is a prerequisite for the prevention and appropriate treatment of those illnesses as well [ 15 , 16 , 17 ].…”