Differences in carcinoembryonic antigen levels between colon and rectal cancer

Ding, Yuanhua; Xuan, Weibo; Chen, Chunlin; Chen, Zhe; Yang, Ziyi; Zuo, Yongchun; Ren, Shuo

doi:10.3892/mco.2014.286

Cited by 18 publications

(13 citation statements)

References 19 publications

(11 reference statements)

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“…These results had been accepted with several other researches such as (Polat et al, 2014) who indicate that serum CEA levels were significantly higher in stages C and D than in stage A. (Ding et al, 2014) reported that the mean of serum's CEA level were higher in dukes stage C of tumor than stage B or A. (Eleftheriadis et al, 2009) found a low sensitivity associated with serum CEA assays in the early stage detection of colorectal cancers.…”

Section: Discussionsupporting

confidence: 68%

“…(Eleftheriadis et al, 2009) found a low sensitivity associated with serum CEA assays in the early stage detection of colorectal cancers. While (Ding et al, 2014) showed that CEA level can be different between Duke stage A and C, C and B, but not between A and B. (Al-bayatti,and jasim 2009) indicate that the elevation of CEA level occur only in patients with advanced stages in colon cancer.…”

Section: Discussionmentioning

confidence: 98%

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Colon Cancer Early Detection by some Serum's Antigenic, Enzymatic and Free- serum's DNA indicators

Azeez¹,

Sulayman²,

Adel³

2018

RJS

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This research include (104) patient's blood serum diagnosed with colon cancer proved by colonoscopy and histopathology. Blood samples had been selected consecutively over the period March 2013 to April 2014 from patients treated in Oncology and Nuclear Medicine hospital, Al-Jumhory hospital/Mosul and azadi Teaching Hospital/Kirkuk. All cases and controls were aged (21-85-years). One hundred normal blood donor individuals had been used as controls. Antigenic tumor markers which include carcino-embryonic antigen (CEA) and Carbohydrate antigen 19-9 (CA 19-9) had been measured in blood's serum from 104 patients with colon cancer. Results indicate a significant elevation (p<0.05) in levels of CEA and C19-9 only in patients with advanced stage C and metastatic stage D compared with control. Beside biochemical enzymatic tumor markers that included Cyclooxygenase, Arginase showed significantly increase (p<0.05) of enzymatic activity for colon cancer patients with early stage (A) compared with controls. While the serum alkaline sphingomyelinase level was significantly decreased (p<0.05) in colon cancer patients in stage A compared with controls and this decrease was independent of Dukes' stage, thus strengthening the hypothesized validity of these assays to be used as serum test for the early detection of colonic neoplasia. The results of this research also revealed a significant increase (p<0.05) in the serum's free DNA in all stages of colon cancer patient's compared with control grope for this it was considered as a good indicator of early detection of colon cancer.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 98%

Colon Cancer Early Detection by some Serum's Antigenic, Enzymatic and Free- serum's DNA indicators

Azeez¹,

Sulayman²,

Adel³

2018

RJS

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“…Numerous blood-borne markers have been examined in rectal cancer including carcinoembryonic antigen (CEA) and several inflammatory proteins, failing to contribute to more accurate staging despite holding prognostic value. 8,9 Circulating nucleic acids in the bloodstream was first recognized by Mandel and Metasis 10 in 1948 with a further emphasis on cancer patients by Leon et al 11 in 1977. Today, cell-free DNA (cfDNA) is known to be a mixture of normal DNA fragments and cancer-specific DNA segments with tumor-specific mutations.…”

Section: Introductionmentioning

confidence: 99%

Cell-free DNA levels and correlation to stage and outcome following treatment of locally advanced rectal cancer

et al. 2017

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Accurate staging of rectal cancer remains essential for optimal patient selection for combined modality treatment, including radiotherapy, chemotherapy and surgery. We aimed at examining the correlation of cell free DNA with the pathologic stage and subsequent risk of recurrence for patients with locally advanced rectal cancer undergoing preoperative chemoradiation. We examined 75 patients with locally advanced rectal cancer receiving preoperative chemoradiation. Blood samples for translational use were drawn prior to rectal surgery. The level of cell free DNA was quantified by digital droplet PCR and expressed as copy number of beta 2 microglobulin. We found a median level of cell free DNA in the AJCC stages I-III of 3100, 8300, and 10,700 copies/mL respectively. For patients with 12 sampled lymph nodes or above, the median level of cell free DNA were 2400 copies/mL and 4400 copies/mL (p = 0.04) for node negative and node positive disease respectively. The median follow-up was 39 months and 11 recurrences were detected (15%). The median level for patients with recurrent disease was 13,000 copies/mL compared to 5200 copies/mL for non-recurrent patients (p = 0.08). We have demonstrated a correlation between the level of total cell free DNA and the pathologic stage and nodal involvement. Furthermore, we have found a trend towards a correlation with the risk of recurrence following resection of localized rectal cancer.

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“…Previous studies reported that AFP could be elevated with patient of primary lung cancer due to hepatic or testicular metastasis [18]. Carcinogenic effect of EC may be due to the formation of active metabolite; Vinyl carbamate (VC), which is potent mutagen and promote formation of electrophilic species that interact with DNA to form the 2-oxoethyl adducts as vinyl chloride [19]. Animals treated with urethane showed significant increase of CEA and the increment was pronounced in the group treated with repeated doses of EC (urethane) that indicated promotion of cellular proliferation of lung [20].…”

Section: Discussionmentioning

confidence: 99%

An Additional risk of Lung Cancer from Recurrent Exposure to Ethyl Carbamate (EC) in BALB/C Mice

Hamzawy¹,

Abo-youssef²

2015

J Cancer Sci Ther

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Ethyl carbamate (EC); urethane is a chemical carcinogen (IARC group 2A). It has been commonly found in the fermented food and beverages. EC induced cancerous lesion in different sites due to the formation of active metabolite; vinyl carbamate (VC). The current study aims to investigate the potential risk of cancerous lesions in small and repeated exposure of ethyl carbamate in BALB/C mice. Three groups of BALBL/C mice were treated for 120 days included untreated control; group treated with a single dose of urethane (1.5 g/kg B.w/i.p) at a day one; group treated with repeated doses, the first at a day one and a second at day sixty (1.5g/ kg B.w/i.p). Ethyl carbamate (EC) exposure showed sever changes of serum biochemical markers, apoptosis markers, inflammatory cytokines as well as lipid peroxide formation in lung homogenate, these changes were pronounced in repeated exposure to ethyl carbamate. In addition, histological examinations revealed that epithelial changes in pulmonary tissues were advanced in animals treated with repeated doses of ethyl carbamate. These findings indicate that repeated exposure to ethyl carbamate of fermented foods and beverages is an additional risk for lung cancer due to permanent mitochondrial dysfunction and increase the cellular mitotic activity.

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Differences in carcinoembryonic antigen levels between colon and rectal cancer

Cited by 18 publications

References 19 publications

Colon Cancer Early Detection by some Serum's Antigenic, Enzymatic and Free- serum's DNA indicators

Colon Cancer Early Detection by some Serum's Antigenic, Enzymatic and Free- serum's DNA indicators

Cell-free DNA levels and correlation to stage and outcome following treatment of locally advanced rectal cancer

An Additional risk of Lung Cancer from Recurrent Exposure to Ethyl Carbamate (EC) in BALB/C Mice

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