Differences in Atherosclerotic Profiles Between Patients With Thoracic and Abdominal Aortic Aneurysms

Thoracic Aortic Aneurysm Frequency and Dissection Are Associated With Fibrillin-1 Fragment Concentrations in Circulation

“…First, we think that it provides the first evidence that a biomarker of ECM degradation is associated with aortic aneurysm location. We could find no previous work on ECM biomarkers showing differences between patients with TAA and AAA, although others have compared lipoprotein-a concentration 23 and concomitant medical conditions 24 between these patient groups. Second, the study sample was derived from an aortic aneurysm registry with standardized procedures for blood and data collection.…”

Coexistent True Aortic Aneurysm as a Cause of Acute Aortic Dissection

“…We previously reported that AAA is more likely to be associated with atherosclerosis than TAA. 10 These facts imply that only atherosclerosis does not contribute to the development of AAD. Furthermore, of all 140 AAD patients, 28 (20%) with coexisting aortic aneurysm were associated with termination or development of AAD and in approximately 10% it was suspected that TAA was associated with the development of AAD.…”

Medical Therapy of Thoracic Aortic Aneurysms

“…18,19 However, it is unclear whether dissection is a true risk factor or dissection was the first manifestation of the aneurysmal disease. Diabetes mellitus may be associated more closely with AAA than with TAA, 16 although several other studies actually suggest an inverse association between diabetes and AAA (ie, patients with diabetes mellitus are less likely to develop AAA). 2 …”

“…14 Current smoking by itself is estimated to be responsible for 0.4-mm/y additional growth rate of aortic aneurysms. 15 Dyslipidemia and hypertension are less powerful risk factors, considered to be associated mainly with the occurrence of AAA, although newer data suggest that hypertension may actually be more closely associated with TAA, 16 and is certainly a risk factor for dissection. Men are more often affected than women.…”