Differences in Associations between Visceral Fat Accumulation and Obstructive Sleep Apnea by Sex

Harada, Yuka; Oga, Toru; Chihara, Yuichi; Azuma, Masanori; Murase, Kimihiko; Toyama, Yoshiro; Aihara, Kensaku; Tanizawa, Kiminobu; Yoshimura, Chikara; Hitomi, Takefumi; Handa, Tomohiro; Tsuboi, Taijū; Mishima, Michiaki; Chin, Kazuo

doi:10.1513/annalsats.201306-182oc

Cited by 43 publications

(33 citation statements)

References 30 publications

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“…The differences in the adipose distribution are greater for visceral adiposity than other types in both sexes [8]. Significantly greater levels of visceral fat was observed among the males in the current study (Table 2), and this is in agreement with two large studies conducted by Harada et al [35,36]. Two other large studies by Couillard et al [37], and Nordström et al [38] explained that the higher visceral fat in males may be associated with increased glucose intolerance, and higher risk of cardio-metabolic diseases [37,38].…”

Section: Discussionsupporting

confidence: 92%

Waist circumference and hip circumference as potential predictors of visceral fat estimate among type 2 diabetic patients at the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana

Eghan

Agyemang-Yeboah

Togbe

et al. 2019

Alexandria Journal of Medicine

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Background: Although visceral fat (VF) and its influence on cardiovascular diseases have been extensively studied among diabetic patients, there is a need for an easier, and less expensive but equally good predictor for VF. This study was conducted to assess potential anthropometric measurements that can be directly linked to visceral fat levels among diabetic patients. Method: 405 diabetic patients attending the Diabetic clinic of the Komfo Anokye Teaching Hospital (KATH) in Kumasi-Ghana were recruited. A well-structured questionnaire was used to obtain the demographic background and brief medical history. Anthropometric measurements were obtained by direct measurement and visceral fat levels was measured using the Body Composition Monitor (Omron ® 500, Germany) which generated digital results on a screen. Results: The total participants comprised 81 males and 324 females, with an average age of 58.5 ± 9.9 years. The females exhibited a higher mean waist circumference (101.4 ± 12.3 cm) and average hip circumference (104.6 ± 9.9 cm) than the males. The female participants also had higher body mass index (BMI) (28.3 ± 5.1 kg/m 2) compared to males (26.5 ± 4.2 kg/m 2). The association between VF and waist circumference was r = 0.631, p ˂ 0.001, followed by hip circumference (r = 0.536; p < 0.001). The significant predictive abilities of waist circumference and hip circumference to identify diabetic patients with high visceral fat were AUC = 0.787; p ˂ 0.001 and AUC = 0.786; p ˂ 0.001, respectively. Conclusion: Waist circumference and hip circumference promise to be potential alternative predictors of visceral fat accumulation in type 2 diabetes.

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Section: Discussionsupporting

confidence: 92%

Waist circumference and hip circumference as potential predictors of visceral fat estimate among type 2 diabetic patients at the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana

Eghan

Agyemang-Yeboah

Togbe

et al. 2019

Alexandria Journal of Medicine

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“…These differences between included and excluded subjects may explain the lack of relationship between anthropometric and OSA severity changes. Finally, since DEXA measurement did not differentiate between subcutaneous and visceral fat mass, the former greatly associated with OSA . This finding might explain the absence of association.…”

Section: Discussionmentioning

confidence: 92%

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study

Martin

Roche

Thomas

et al. 2015

Obesity

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Objective: Obesity and aging are considered risk factors for developing sleep apnea syndrome (OSA). The aim of this study was to determine the association between body fat composition and OSA in healthy elderly subjects examined in a 7-year longitudinal study. Methods: A total of 209 elderly with unrecognized OSA aged 68.3 6 0.8 years underwent a clinical, ambulatory nocturnal respiratory recording, and anthropometric as well as body fat composition assessment by dual-energy X-ray absorptiometry (DEXA) at baseline and follow-up. Results: At study entry, 50.3% of the population showed an apnea1hypopnea index (AHI) <15 with a mean AHI of 16.8 6 11. At follow-up, a reduction of OSA cases (42%) was evident with a mean AHI of 14.6 6 10.2. The DEXA data demonstrated that body mass and total lean mass were reduced at followup, while central and peripheral fat mass showed a slight increase. Correlation analysis between the changes in DEXA measurements versus the changes in AHI and the indices of nocturnal hypoxemia showed an absence of a statistical correlation. Conclusions: The lack of correlation between the DEXA measurement changes and the changes in the AHI confirm our previous data on the absence of a central fat mass effect on OSA in the elderly.

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“…As total cholesterol and LDL cholesterol levels have been found to be negatively correlated with adiponectin in PWS [31], the deterioration in lipid profiles seen in our study may be due to the changes in Table 6 The raw values of parameters in each PWS patient adipocytokines. Furthermore, as increased VAT is associated with obstructive sleep apnea syndrome [33], one of the causes of death in PWS adults, maintaining an appropriate body composition by continuation of GH therapy from childhood to adulthood is important to maintain a higher quality of life (QOL) in adult PWS patients. GH therapy improves body composition and lipid profiles both in children [34][35][36][37][38][39][40][41][42][43][44] and adults PWS patients [45][46][47][48][49][50][51][52]; therefore, continuation of GH therapy after adult height is achieved may be beneficial for maintaining body composition, which eventually reduces the risk of obesity-related complications in adults with PWS.…”

Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue increases shortly after the cessation of GH therapy in adults with Prader-Willi syndrome

et al. 2018

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GH therapy in pediatric patients with Prader-Willi syndrome (PWS) improves body composition, but discontinuation of GH after achieving adult height has been implicated in its deterioration. Although there is evidence for the deleterious effects of visceral adipose tissue (VAT) rather than subcutaneous adipose tissue (SAT) on the development of obesity-related complications, the effects of GH discontinuation on fat distribution in adults with PWS has not been fully investigated. Therefore, we utilized dual-energy X-ray absorptiometry (DEXA) and abdominal computed tomography (CT) to compare the fat distribution between before and 6 months or 12 months after the cessation of GH therapy in 7 adult PWS patients. GH therapy was initiated at a mean age of 4.1 ± 1.4 years and discontinued at a mean age of 18.9 ± 1.8 years. Serum IGF-1 levels were decreased by discontinuation of GH therapy. Fat mass was significantly increased 6 and 12 months after GH cessation, whereas muscle mass and bone mineral density were unchanged during both study periods. Abdominal CT analysis revealed that elevations in fat mass were due to increases in VAT rather than SAT. Circulating low-density lipoprotein (LDL) cholesterol levels were significantly elevated 6 months after GH cessation. In conclusion, discontinuation of GH therapy caused rapid increases in visceral adipose tissue and LDL cholesterol levels. These findings indicate that continuation of GH therapy may be a therapeutic option to maintain body composition; however, further studies regarding the long-term benefits and adverse effects of GH therapy in adults with PWS are required.

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Differences in Associations between Visceral Fat Accumulation and Obstructive Sleep Apnea by Sex

Abstract: Only in men was OSA independently associated with VFA. The lesser associations between OSA and visceral fat in women might account for the lower impact of OSA on cardiovascular disease or mortality in women.

Cited by 43 publications

References 30 publications

Waist circumference and hip circumference as potential predictors of visceral fat estimate among type 2 diabetic patients at the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana

Waist circumference and hip circumference as potential predictors of visceral fat estimate among type 2 diabetic patients at the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study

Visceral adipose tissue increases shortly after the cessation of GH therapy in adults with Prader-Willi syndrome

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