Differences in arterial and venous thromboelastography parameters: Potential roles of shear stress and oxygen content

Frumento, Robert J.; Hirsh, Andrew; Parides, Michael K.; Bennett‐Guerrero, Elliott

doi:10.1053/jcan.2002.126946

Cited by 28 publications

(23 citation statements)

References 17 publications

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“…Blann et al [4] performed full CBC analysis in arterial and venous blood from humans undergoing diagnostic angiography and found no differences in any of the hematological variables. Frumento et al [9] performed a similar study evaluating Hct values in humans undergoing cardiac surgery and also noted no differences between arterial and venous blood.…”

Section: Discussionmentioning

confidence: 87%

Inter-species hemorheologic differences in arterial and venous blood

Son

Lim

Song

et al. 2010

Clinical Hemorheology and Microcirculation

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Background: Hemorheologic factors such as red blood cell (RBC) aggregation and deformability differ according to species. In many comparative hemorheologic studies, only venous blood samples have been used for measurements. There is little published information comparing arterial and venous blood differences between species. We compared hemorheologic factors in arterial and venous blood in rats, dogs and humans.Methods: Nineteen dogs and 12 rats were used. Human blood was obtained from 12 healthy volunteers. Blood gas analysis, hematocrit and elongation index which represents RBC deformability were measured in arterial and venous blood samples. The critical shear stress and aggregation index, both of which represent RBC aggregation, were also measured in arterial and venous blood.Results: There were no arterial or venous differences in hematocrit, critical shear stress, or elongation index in dogs. In rats, RBC aggregation was not measurable. The hematocrit and elongation index of arterial blood were significantly lower than those of venous blood in rats. There were no arterial or venous differences in hematocrit, aggregation index, or elongation index in humans.Conclusion: Arterial and venous hemorheologic factors differed depending on the species. Further standardization is necessary for the measurement of hemorheologic variables.

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Section: Discussionmentioning

confidence: 87%

Inter-species hemorheologic differences in arterial and venous blood

Son

Lim

Song

et al. 2010

Clinical Hemorheology and Microcirculation

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“…Vacuum‐assisted collection is expected to promote shear stress, and shear stress is known to cause platelet activation and result in platelet aggregation . TEG results generated for human cardiopulmonary bypass patients have been shown to be significantly affected by collection through different intravenous catheters, and the differences in TEG tracings were considered likely due to differences in shear stress and subsequent platelet aggregation . In our study, paired blood samples were exposed to similar shear stress during the collection process, but during transfer to plastic tubes, samples transferred with vacuum assistance had greater shear stress than samples transferred without vacuum assistance.…”

Section: Discussionmentioning

confidence: 99%

“…TEG is also being used clinically to diagnose coagulation abnormalities, especially hypercoagulable states, and to direct therapy, such as anticoagulant therapy . However, there are no published guidelines for such use, and there are few guidelines regarding collection and handling of samples prior to TEG in either human or veterinary medicine . Samples for TEG in published research have been collected using 21‐gauge butterfly catheters attached to evacuated tubes containing sodium citrate, 21‐gauge needles attached to syringes before transfer to evacuated tubes containing sodium citrate, and needles directly attached to evacuated tubes, as well as from central venous catheters .…”

Section: Introductionmentioning

confidence: 99%

Effects of delayed anticoagulation and use of evacuated tubes on non‐activated thrombelastography in dogs

Koenigshof¹,

Scott

Brown³

2012

Veterinary Clinical Pathol

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“…The site of blood sampling seems not to be neglectable, especially when comparing patients in a study or if there is repeated measurements on the same patient. It has been shown that there are differences between the sampling sites, not related to the oxygen content but to the calculated shear forces in the corresponding blood vessel [12]. …”

Section: Thrombelastography—assessing the Viscoelastic Properties mentioning

confidence: 99%

The Role of Thrombelastography in Multiple Trauma

Jeger

Zimmermann

Exadaktylos

2011

Emergency Medicine International

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Hemorrhage and traumatic coagulopathyis are major causes of early death in multiply injured patients. Thrombelastography (TEG) seems to be a fast and accurate coagulation test in trauma care. We suggest that multiply injured trauma patients would benefit the most from an early assessment of coagulation by TEG, mainly RapidTEG, to detect an acute traumatic coagulopathy and especially primary fibrinolysis, which is related with high mortality. This review gives an overview on TEG and its clinical applications.

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Differences in arterial and venous thromboelastography parameters: Potential roles of shear stress and oxygen content

Cited by 28 publications

References 17 publications

Inter-species hemorheologic differences in arterial and venous blood

Inter-species hemorheologic differences in arterial and venous blood

Effects of delayed anticoagulation and use of evacuated tubes on non‐activated thrombelastography in dogs

The Role of Thrombelastography in Multiple Trauma

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