Differences in Anti Malarial Antibody Concentrations and Specificities between Male and Female Ugandan Children

Apio, Okech Brenda; Corran, Patrick H.; Todd, J; Agwang, Constance; Riley, E. M.; Tg, Egwang

doi:10.36959/885/367

Cited by 4 publications

(1 citation statement)

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“…Females generally mount more robust innate and adaptive immune responses and demonstrate a higher rate of morbidity and prevalence of autoimmune diseases by comparison with males (3,4). Females have demonstrated higher levels of antibodies following natural infections (5) and malaria SPf66 vaccination (6, 7), and higher rates of severe adverse events and mortality following SPf66 and RTS,S/AS01 malaria vaccinations (4,8). Furthermore, female neonates exposed to malaria in utero demonstrate higher numbers of regulatory T-cell (Tregs) at birth (9) and female children clear asymptomatic malaria faster than male children (10).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in concentrations of HMGB1 and numbers of pigmented monocytes in infants and young children with malaria

Kanoi¹,

Egwang²

2021

Parasitology International

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Section: Introductionmentioning

confidence: 99%

Sex differences in concentrations of HMGB1 and numbers of pigmented monocytes in infants and young children with malaria

Kanoi¹,

Egwang²

2021

Parasitology International

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Sex-Linked Differences in Malaria Risk Across the Lifespan

Briggs,

Murray,

Nideffer

et al. 2023

Current Topics in Microbiology and Immunology

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Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

et al. 2022

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T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the host and parasite factors that influence Tfh and functional antibody development. Here, we use samples from a large cross-sectional study of children residing in an area of high malaria transmission in Uganda to characterize Tfh cells and functional antibodies to multiple parasites stages. We identify a dramatic re-distribution of the Tfh cell compartment with age that is independent of malaria exposure, with Th2-Tfh cells predominating in early childhood, while Th1-Tfh cell gradually increase to adult levels over the first decade of life. Functional antibody acquisition is age-dependent and hierarchical acquired based on parasite stage, with merozoite responses followed by sporozoite and gametocyte antibodies. Antibodies are boosted in children with current infection, and are higher in females. The children with the very highest antibody levels have increased Tfh cell activation and proliferation, consistent with a key role of Tfh cells in antibody development. Together, these data reveal a complex relationship between the circulating Tfh compartment, antibody development and protection from malaria.

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Differences in Anti Malarial Antibody Concentrations and Specificities between Male and Female Ugandan Children

Cited by 4 publications

References 0 publications

Sex differences in concentrations of HMGB1 and numbers of pigmented monocytes in infants and young children with malaria

Sex differences in concentrations of HMGB1 and numbers of pigmented monocytes in infants and young children with malaria

Sex-Linked Differences in Malaria Risk Across the Lifespan

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

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