Differences Between Cystatin C– and Creatinine-Based Estimated GFR—Early Evidence of a Clinical Marker for Frailty

McAdams‐DeMarco, Mara; Chu, Nadia M.; Segev, Dorry L.

doi:10.1053/j.ajkd.2020.07.010

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…With advanced age, and its highest level was within the older age groups (60-69 and >_ 70) years old, which is consistent with many studies [51,52], the study also agrees with [53],who stated that cystatin C levels rise in patients with diabetic nephropathy, especially in elderly people aging 65 and above with low GFR. The reason may be that after cystatin C is produced by all nucleated cells it is freely filtered by the renal glomeruli because of its low molecular weight, thereby any defect in the filtration process leads to a rise in its levels in the blood.…”

Section: Discussionsupporting

confidence: 90%

Assessing the Level of a Trial Natriuretic Peptide and Some Biochemical Parameters in Men With Type 2 Diabetic Nephropathy

AL-FATLAWI¹,

Jwad²

2022

UPJOZ

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The Aim: The current study is conducted to diagnose the relationship between ANP levels and diabetic nephropathy, the applicability of adopting it as a biomarker or an early index to prevent renal failure. Study Design: The current study estimates the levels of atrial natriuretic peptide and some biochemical parameters in healthy subjects and patients with type 2 diabetes. Place and Duration of Study: The study duration was from 1/3/2021 to 1/10/2021. The patients were divided into several groups based on their age, diabetic duration, albumin to creatinine ratio (ACR) and glomerular filtration rate. Methodology: It determines the possibility of adopting these levels in diagnosing the progression of diabetic nephropathy. The study also included a follow-up of (60) men with type 2 diabetes who were attending the Diabetes and Endocrinology Center of Al-Sadr Medical Hospital in Najaf, as well as (15) men from the Dialysis Center of the same hospital, and (15) healthy men as a control group, their ages were (30-80) years. Results: The trial showed a significant effect (P<0.05) for age groups and diabetic duration on the levels of atrial natriuretic peptide, cystatin C, amyloid A, serum creatinine, albumin to creatinine ratio in urine, and glomerular filtration rate. However, no significant differences (P>0.05) were observed in the albumin level in serum. Moreover, the results showed a noticeable increase (P<0.05) in the levels of atrial natriuretic peptide, cystatin C, amyloid A, creatinine in serum and glomerular filtration rate with an increase in albuminuria. Conclusion: A significant increment was indicated by the results reading (P<0.05) in the levels of atrial natriuretic peptide, cystatin C, amyloid A, creatinine in serum and the ratio of albumin to creatinine with the progression of the stages of diabetic nephropathy.

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Section: Discussionsupporting

confidence: 90%

Assessing the Level of a Trial Natriuretic Peptide and Some Biochemical Parameters in Men With Type 2 Diabetic Nephropathy

AL-FATLAWI¹,

Jwad²

2022

UPJOZ

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Frailty detection with routine blood tests using data from the english longitudinal study of ageing (ELSA)

He,

Yang,

Lin

et al. 2024

Eur Geriatr Med

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Intraindividual difference in estimated GFR by creatinine and cystatin C, cognitive trajectories and motoric cognitive risk syndrome

Wang,

Liu,

Jin

et al. 2023

Nephrology Dialysis Transplantation

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Background Intraindividual differences between estimated glomerular filtration rate (eGFR) based on cystatin C (eGFRcys) and creatinine (eGFRcr) can convey important clinical information regarding health status. However, the clinical implications of these differences (eGFRdiff) for risk of cognitive decline and motoric cognitive risk (MCR) syndrome remains unclear. We aimed to investigate the longitudinal associations of eGFRdiff with cognitive trajectories and incident MCR. Methods Based on the China Health and Retirement Longitudinal Study, we identified two study subcohorts: one for cognitive trajectory follow-up (6423 participants, 2011–2018) and another for incident MCR follow-up (2477 participants, 2011–2015). The eGFRdiff was defined as eGFRcys − eGFRcr. Adjusted ordinal and binary logistic regression models were separately used to assess the associations of eGFRdiff with cognitive trajectories and incident MCR. We also performed discordance analyses for eGFRdiff versus eGFRcys, eGFRcr or eGFR based on both creatinine and cystatin C (eGFRcys-cr). Results In the first subcohort, four distinct 7-year cognitive trajectories were identified. Each 1 standard deviation (SD) higher eGFRdiff (value for eGFRcys − eGFRcr) was associated with a lower risk of poorer cognitive trajectories {odds ratio 0.909 [95% confidence interval (CI) 0.877–0.942]}. In the second subcohort, 121 participants developed incident MCR after a 4-year follow-up. Each 1-SD higher eGFRdiff (value for eGFRcys − eGFRcr) was linked with a 25.3% (95% CI 16.6–33.2) decreased risk for MCR. The above associations persisted in individuals with normal kidney function. Additionally, the risk for cognitive decline and incident MCR was more strongly associated with eGFRcys than eGFRcr and eGFRcys-cr. For the discordance analyses, the ‘discordantly high eGFRdiff/low eGFR’ group but not the ‘discordantly low eGFRdiff/high eGFR’ exhibited a significantly lower risk of poorer cognitive trajectories and MCR compared with the concordant group. Conclusions A large negative difference between eGFRcys and eGFRcr (eGFRcys < eGFRcr) was associated with a higher risk of cognitive decline and incident MCR. The eGFRdiff could capture additional valuable risk information beyond eGFRcys, eGFRcr and eGFRcys-cr.

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Differences Between Cystatin C– and Creatinine-Based Estimated GFR—Early Evidence of a Clinical Marker for Frailty

Abstract: F railty is defined as a medical syndrome of multisystem dysregulation and is manifested as compromised resistance to stressors that increases vulnerability to dependence and mortality. 1 Although frailty was originally

Cited by 4 publications

References 17 publications

Assessing the Level of a Trial Natriuretic Peptide and Some Biochemical Parameters in Men With Type 2 Diabetic Nephropathy

Assessing the Level of a Trial Natriuretic Peptide and Some Biochemical Parameters in Men With Type 2 Diabetic Nephropathy

Frailty detection with routine blood tests using data from the english longitudinal study of ageing (ELSA)

Intraindividual difference in estimated GFR by creatinine and cystatin C, cognitive trajectories and motoric cognitive risk syndrome

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