Difference in taste quality coding between two cortical taste areas, granular and dysgranular insular areas, in rats

Ogawa, Hisashi; Hasegawa, Kayoko; Murayama, Nobuki

doi:10.1007/bf00227838

Cited by 63 publications

(35 citation statements)

References 21 publications

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“…Whereas the AI was considered not labeled, GI and DI revealed a pattern comparable to the sensory areas. This is compatible with the cytoarchitectural gradients and involvement of insular cortex in somatosensory functions (Ogawa et al 1991(Ogawa et al , 1992Sewards and Sewards 2001, Craig 2002, 2009). …”

Section: Nf-l Content and Myelinationsupporting

confidence: 66%

Cytoarchitecture of the mouse neocortex revealed by the low-molecular-weight neurofilament protein subunit

et al. 2011

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The expression patterns of the medium- and high-molecular-weight subunits of the neurofilament protein triplet have been extensively studied in several neuroanatomical studies. In the present study, we report the use of the low-molecular-weight neurofilament protein subunit (NF-L) as a reliable marker within the neurofilament protein family to reveal the regional architecture of mammalian neocortex. We document clearly its usefulness in anatomical parcellation studies and report unique expression patterns of NF-L throughout the mouse neocortex. NF-L was most abundant in the somatosensory cortex, the lateral secondary visual area, the granular insular cortex, and the motor cortex. Low NF-L staining intensity was observed in the agranular insular cortex, the prelimbic and infralimbic cortex, the anterior cingulate cortex, the visual rostromedial areas, the temporal association cortex, the ectorhinal cortex, and the lateral entorhinal cortex. NF-L immunoreactivity was present in the perikarya, dendrites, and proximal segment of axons primarily of pyramidal neurons, and was mainly located in layers II and III, and to a lesser extent in layers V and VI. Interestingly, Black-Gold myelin staining confirmed a close correlation between NF-L immunoreactivity and myelination patterns. The characteristic and distinctive distribution and laminar expression profiles of NF-L make it an excellent tool to assess accurately topographical boundaries among neocortical areas as illustrated herein in the adult mouse brain.

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Section: Nf-l Content and Myelinationsupporting

confidence: 66%

Cytoarchitecture of the mouse neocortex revealed by the low-molecular-weight neurofilament protein subunit

et al. 2011

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“…sweet, salty, sour, bitter and umami. Extracellular recordings in anesthetized rodents [36–38,**39,40] have shown that while the majority of taste processing neurons are located in gIC and dIC, neurons in aIC can also display gustatory responses [36,41]. This result is consistent with evidence of direct VPMpc inputs to gIC and dIC and with indications that these two subdivisions might relay gustatory signals to aIC.…”

Section: Coding Of Taste Quality In Icsupporting

confidence: 64%

Neural processing of gustatory information in insular circuits

Maffei

Haley

Fontanini

2012

Current Opinion in Neurobiology

118

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The insular cortex is the primary cortical site devoted to taste processing. A large body of evidence is available for how insular neurons respond to gustatory stimulation in both anesthetized and behaving animals. Most of the reports describe broadly tuned neurons that are involved in processing the chemosensory, physiological and psychological aspects of gustatory experience. However little is known about how these neural responses map onto insular circuits. Particularly mysterious is the functional role of the three subdivisions of the insular cortex: the granular, the dysgranular and the agranular insular cortices. In this article we review data on the organization of the local and long-distance circuits in the three subdivisions. The functional significance of these results is discussed in light of the latest electrophysiological data. A view of the insular cortex as a functionally integrated system devoted to processing gustatory, multimodal, cognitive and affective information is proposed.

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“…Physiological recordings from rats indicate that cortical neurons tend to be heterogeneous in terms of quality coding and breadth-of-responsiveness (e.g. Ogawa et al, 1992; Hanamori et al, 1998; Simon et al, 2006), and similar to the brainstem areas there is some tendency for segregation of primary tastes, including sucrose responses anterodorsally and quinine responses posteriorly (Yamamoto et al, 1985). This latter result was supported by an in vivo surface optical imaging study that reported distinct, yet substantially overlapping activation patterns in response to basic tastes in the rat (Accolla et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study

Tokita

Boughter

2016

Neuroscience

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The activities of 178 taste-responsive neurons were recorded extracellularly from the parabrachial nucleus (PbN) in the anesthetized C57BL/6J mouse. Taste stimuli included those representative of 5 basic taste qualities, sweet, salty, sour, bitter and umami. Umami synergism was represented by all sucrose-best and sweet-sensitive sodium chloride-best neurons. Mediolaterally the PbN was divided into medial, brachium conjunctivum (BC) and lateral subdivisions while rostrocaudally the PbN was divided into rostral and caudal subdivisions for mapping and reconstruction of recording sites. Neurons in the medial and BC subdivisions had a significantly greater magnitude of response to sucrose and to the mixture of monopotassium glutamate and inosine monophosphate than those found in the lateral subdivision. In contrast, neurons in the lateral subdivision possessed a more robust response to quinine hydrochloride. Rostrocaudally no difference was found in the mean magnitude of response. Analysis on the distribution pattern of neuron types classified by their best stimulus revealed that the proportion of neuron types in the medial vs. lateral and BC vs. lateral subdivisions was significantly different, with a greater amount of sucrose-best neurons found medially and within the BC, and a greater amount of sodium chloride-, citric acid- and quinine hydrochloride-best neurons found laterally. There was no significant difference in the neuron type distribution between rostral and caudal PbN. We also assessed breadth of tuning in these neurons by calculating entropy (H) and noise-to-signal (N/S) ratio. Mean N/S ratio of all neurons (0.43) was significantly lower than that of H value (0.64). Neurons in the caudal PbN had a significantly higher H value than in the rostral PbN. In contrast, mean N/S ratio were not different both mediolaterally and rostrocaudally. These results suggest that although there is overlap in taste quality representation in the mouse PbN, taste-responsive neurons still possessed a topographic organization.

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Difference in taste quality coding between two cortical taste areas, granular and dysgranular insular areas, in rats

Cited by 63 publications

References 21 publications

Cytoarchitecture of the mouse neocortex revealed by the low-molecular-weight neurofilament protein subunit

Cytoarchitecture of the mouse neocortex revealed by the low-molecular-weight neurofilament protein subunit

Neural processing of gustatory information in insular circuits

Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study

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